Title: Book the Best BUSINESS Hotels in Central Missouri in 2026 | Expedia.ca [Central Missouri Travel Guide](https://expedia.ca/Central-Missouri.dx6058776)[Hotels in Central Missouri](https://expedia.ca/Central-Missouri-Hotels.d6058776.Travel-Guide-Hotels)[Vacation Rentals in Central Missouri](https://expedia.ca/Central-Missouri-Vacation-Rentals.d6058776.Travel-Guide-VacationRentals)[Flights to Central Missouri](https://expedia.ca/Cheap-Flights-To-Central-Missouri.d6058776.Travel-Guide-Flights)[Things to do in Central Missouri](https://expedia.ca/Things-To-Do-In-Central-Missouri.d6058776.Travel-Guide-Activities)[Central Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Central-Missouri.d6058776.Car-Rental-Guide)[Central Missouri Vacation Packages](https://expedia.ca/Central-Missouri.d6058776.Destination-Travel-Guides) ![Missouri State Capitol which includes an administrative building, heritage architecture and a fountain](https://images.trvl-media.com/place/6092643/f7036169-7e6d-403b-b3a3-fac711433497.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Central Missouri, MO from CA $108 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central Missouri Business Hotels Tonight [Dec 29 - Dec 30](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2025-12-29&endDate=2025-12-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 30 - Dec 31](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2025-12-30&endDate=2025-12-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Central Missouri business-friendly hotels ![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/4071c448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/136440e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children's play area - outdoor](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/104061b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/db5aadc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Echo Bluff State Park [](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information) Eminence 9.6/10 Exceptional (217) "The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joanne CA $202 CA $214 total includes taxes & fees Jan 28 - Jan 29, 2026 [](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/8a05cd33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/w6000h3998x0y0-b5960fdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/83e9f93b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/4d96f21b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG [](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Hotel-Suites-Columbia-Univ-Area-Hwy-63.h7677926.Hotel-Information) Columbia 8.8/10 Excellent (1000) "Very clean hotel with friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara CA $135 CA $154 total includes taxes & fees Jan 18 - Jan 19, 2026 [](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Hotel-Suites-Columbia-Univ-Area-Hwy-63.h7677926.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7e36eb59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/41084352.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/40992baf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/d106f50c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lodge Of Four Seasons Golf Resort, Marina & Spa [](https://www.expedia.ca/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) Lake Ozark 7.4/10 Good (1090) "Great Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen CA $105 CA $146 total includes taxes & fees Jan 12 - Jan 13, 2026 [](https://www.expedia.ca/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/86998653.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gym](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/ea852bf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/9c49804e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/16b33223.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Executive Center Columbia [](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Executive-Center-Columbia-Mall.h22359.Hotel-Information) Columbia 8.4/10 Very good (1006) "Spotless room, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kent CA $116 CA $131 total includes taxes & fees Jan 25 - Jan 26, 2026 [](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Executive-Center-Columbia-Mall.h22359.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/2c317c73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/805c2520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/bd7f5440.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/fd258818.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Columbia Inn [](https://www.expedia.ca/Columbia-Hotels-Best-Western-Plus-Columbia-Inn.h12546284.Hotel-Information) Columbia 8.8/10 Excellent (1205) "Stayed here several times and was very happy with our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reynaldo CA $95 CA $108 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Columbia-Hotels-Best-Western-Plus-Columbia-Inn.h12546284.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/800000/794300/794290/1e51ead0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/800000/794300/794290/8ad6955b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/800000/794300/794290/8989ced7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/800000/794300/794290/8bf18cbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel [](https://www.expedia.ca/Clinton-Hotels-Hotel-Bothwell-Sedalia-Central-District.h794290.Hotel-Information) Sedalia Downtown Historic District 9.2/10 Wonderful (582) "Great place. Beautifully decorated for the season. Great staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leah CA $150 CA $170 total includes taxes & fees Jan 28 - Jan 29, 2026 [](https://www.expedia.ca/Clinton-Hotels-Hotel-Bothwell-Sedalia-Central-District.h794290.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/890000/882800/882709/74a00d2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/890000/882800/882709/13784ba7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/890000/882800/882709/e6a5e156.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/890000/882800/882709/faed32e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites Lake of the Ozarks [](https://www.expedia.ca/Osage-Beach-Hotels-Sleep-Inn-Suites-Lake-Of-The-Ozarks.h882709.Hotel-Information) Camdenton 8.8/10 Excellent (978) "Great room, great breakfast, great price" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kent CA $148 CA $160 total includes taxes & fees Dec 31 - Jan 1, 2026 [](https://www.expedia.ca/Osage-Beach-Hotels-Sleep-Inn-Suites-Lake-Of-The-Ozarks.h882709.Hotel-Information) ![Casino](https://images.trvl-media.com/lodging/10000000/9750000/9747200/9747129/d7688c2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9750000/9747200/9747129/ebf5de16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9750000/9747200/9747129/0c19f127.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/10000000/9750000/9747200/9747129/8976c793.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Isle of Capri Casino Hotel Boonville - A Caesars Rewards Destination [](https://www.expedia.ca/Columbia-Hotels-Isle-Of-Capri-Casino-Hotel-Boonville.h9747129.Hotel-Information) Boonville 8.2/10 Very good (950) "Very comfortable room and great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard [](https://www.expedia.ca/Columbia-Hotels-Isle-Of-Capri-Casino-Hotel-Boonville.h9747129.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61500/61461/68d45684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61500/61461/154d2b9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/70000/61500/61461/2fd4f559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61500/61461/234ceb40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Warrensburg [](https://www.expedia.ca/Warrensburg-Hotels-Quality-Inn.h61461.Hotel-Information) Warrensburg 8.6/10 Excellent (646) "Staff was great and hotel had the best amenities in the area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $119 CA $136 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/Warrensburg-Hotels-Quality-Inn.h61461.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42129/3e728377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42129/56b56482.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42129/33542641.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42200/42129/a7c5548b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Columbia Stadium Boulevard [](https://www.expedia.ca/Columbia-Hotels-Drury-Inn-Suites-Columbia-Stadium-Boulevard.h42129.Hotel-Information) Columbia 9.4/10 Exceptional (1003) "Very clean and staff was excellent!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Audrey CA $123 CA $139 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Columbia-Hotels-Drury-Inn-Suites-Columbia-Stadium-Boulevard.h42129.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-12&endDate=2026-01-13®ionId=6058776&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Central Missouri Hotel Reviews ![Wingate by Wyndham - Columbia](https://images.trvl-media.com/lodging/1000000/990000/986100/986086/a16387a6_y.jpg) ### Wingate by Wyndham - Columbia 10/10 Excellent "Clean, friendly staff, comfortable bed and excellent shower ." [](https://expedia.ca/Columbia-Hotels-Wingate-By-Wyndham-Columbia.h986086.Hotel-Information) ![Country Inn & Suites by Radisson, Columbia, MO](https://images.trvl-media.com/lodging/2000000/1660000/1658500/1658463/c8809092_y.jpg) ### Country Inn & Suites by Radisson, Columbia, MO 10/10 Excellent "Great and friendly check in" [](https://expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1658463.Hotel-Information) ![Wyndham Executive Center Columbia](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/86998653_y.jpg) ### Wyndham Executive Center Columbia 10/10 Excellent "Everything was clean and the staff was very on top of it! " [](https://expedia.ca/Columbia-Hotels-Holiday-Inn-Executive-Center-Columbia-Mall.h22359.Hotel-Information) ![Baymont by Wyndham Columbia, MO](https://images.trvl-media.com/lodging/1000000/50000/40200/40115/08435bc3_y.jpg) ### Baymont by Wyndham Columbia, MO 10/10 Excellent "We had a great stay at this place. We tend to drive between Denver and St. Louis area often, and it’s nice to have this place on our list of approved places. You can tell they really care about providing a nice place to stay." [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Columbia.h40115.Hotel-Information) ![Stoney Creek Hotel Columbia](https://images.trvl-media.com/lodging/2000000/1060000/1052400/1052330/5398551a_y.jpg) ### Stoney Creek Hotel Columbia 10/10 Excellent "Everything was as expected. " [](https://expedia.ca/Columbia-Hotels-Stoney-Creek-Hotel-Columbia.h1052330.Hotel-Information) ![Quality Inn St. Robert - Ft. Leonard Wood](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/63ed2b69_y.jpg) ### Quality Inn St. Robert - Ft. Leonard Wood 10/10 Excellent "Very nice room." [](https://expedia.ca/Rolla-Hotels-Quality-Inn-St-Robert-Ft-Leonard-Wood.h218324.Hotel-Information) ![Lodge Of Four Seasons Golf Resort, Marina & Spa](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7e36eb59_y.jpg) ### Lodge Of Four Seasons Golf Resort, Marina & Spa 10/10 Excellent "Loved the warm pool! The Santa workshop treat was amazing! " [](https://expedia.ca/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) ![Camden on the Lake Resort & Spa](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/21eb378b_y.jpg) ### Camden on the Lake Resort & Spa 10/10 Excellent "It was fancy. " [](https://expedia.ca/Osage-Beach-Hotels-Camden-On-The-Lake-Resort-Spa.h2015357.Hotel-Information) ![Drury Inn & Suites Columbia Stadium Boulevard](https://images.trvl-media.com/lodging/1000000/50000/42200/42129/3e728377_y.jpg) ### Drury Inn & Suites Columbia Stadium Boulevard 10/10 Excellent "Such a great orient" [](https://expedia.ca/Columbia-Hotels-Drury-Inn-Suites-Columbia-Stadium-Boulevard.h42129.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Central Missouri cost? ### What are the best business-friendly hotels in Central Missouri? ### How many business-friendly hotels are there in Central Missouri? ### What are the best cheap business-friendly hotels in Central Missouri? ### Are there any family-friendly hotels in Central Missouri that are also business friendly? ### Are there any 5-star business-friendly hotels in Central Missouri? ### Why book your business-friendly hotel in Central Missouri with Expedia? ### How can I find cheap business-friendly hotels in Central Missouri? ### What is there to do in Central Missouri near my business-friendly hotel? ## Explore a world of travel with Expedia - 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