Title: Book the Best BUSINESS Hotels in Caseyville in 2026 | Expedia.ca [Hotels in Caseyville](https://expedia.ca/Caseyville-Hotels.d6580.Travel-Guide-Hotels)[Vacation Rentals in Caseyville](https://expedia.ca/Caseyville-Vacation-Rentals.d6580.Travel-Guide-VacationRentals)[Flights to Caseyville](https://expedia.ca/Cheap-Flights-To-Caseyville.d6580.Travel-Guide-Flights)[Caseyville Car Rentals](https://expedia.ca/Car-Rentals-In-Caseyville.d6580.Car-Rental-Guide)[Caseyville Vacation Packages](https://expedia.ca/Caseyville.d6580.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/6142384/60a656d6-7005-4ef1-bf2a-603f64ce6e1b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by LJ Alan ![](https://images.trvl-media.com/place/6142384/60a656d6-7005-4ef1-bf2a-603f64ce6e1b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Caseyville Business Hotels Tonight [Mar 28 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=6580&startDate=2026-03-28&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Mar 29 - Mar 30](https://www.expedia.ca/Hotel-Search?regionId=6580&startDate=2026-03-29&endDate=2026-03-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=6580&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=6580&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Caseyville business-friendly hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/120000/117300/117279/d96b5525.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/120000/117300/117279/w6000h2998x0y0-d02868ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/120000/117300/117279/edf79243.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/1000000/120000/117300/117279/f2b10271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Caseyville - St. Louis [](https://www.expedia.ca/Collinsville-Hotels-Quality-Inn-Suites-Caseyville-St-Louis.h117279.Hotel-Information) Caseyville 5.8/10 (646 reviews) "Overall the stay was ok" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sabrina CA $87 CA $98 total includes taxes & fees Apr 13 - Apr 14 [](https://www.expedia.ca/Collinsville-Hotels-Quality-Inn-Suites-Caseyville-St-Louis.h117279.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/2e5b0061.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/9953fcfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/d789f3f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/7fef19fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites St. Louis O'Fallon, IL [](https://www.expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-OFallon.h1544028.Hotel-Information) O'Fallon 9.6/10 Exceptional (1,010 reviews) "Clean room, friendly staff, great food. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pamela CA $147 CA $171 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-OFallon.h1544028.Hotel-Information) ![Deluxe Studio Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/11100/11071/055d0e3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 10 AM to 10 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/11100/11071/e59929f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/11100/11071/82aaa575.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11071/bad6b55f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham O'Fallon [](https://www.expedia.ca/Collinsville-Hotels-Super-8-By-Wyndham-OFallon.h11071.Hotel-Information) O'Fallon 7.0/10 Good (1,005 reviews) "We choose not to stay, it was quite run down. We found one of many hotels in the downtown Shiloh area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lance CA $75 CA $86 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Collinsville-Hotels-Super-8-By-Wyndham-OFallon.h11071.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42035/fff178d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42035/277e17ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42100/42035/e281e57d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/42100/42035/e26024c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites St. Louis Collinsville [](https://www.expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Collinsville.h42035.Hotel-Information) Eastport 9.6/10 Exceptional (1,001 reviews) "Check in was easy, staff was friendly. The room was clean and breakfast was great. We will definitely stay at the Drury again in the future! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cyel CA $157 CA $180 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Collinsville.h42035.Hotel-Information) ![Suite, 1 King Bed, Non Smoking (One-Bedroom, Honeymoon) | Jetted tub](https://images.trvl-media.com/lodging/1000000/210000/202600/202597/2bb7b058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/210000/202600/202597/2c52f69d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/210000/202600/202597/3b6fe12d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/210000/202600/202597/7eaefc44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Seasons Inn & Suites Highland [](https://www.expedia.ca/Highland-Hotels-Seasons-Inn-Suites-Highland.h202597.Hotel-Information) Highland 8.0/10 Very good (637 reviews) "The staff is very friendly and accommodating they took care of us very well. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Philip CA $130 CA $145 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Highland-Hotels-Seasons-Inn-Suites-Highland.h202597.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/9000000/8140000/8132000/8131949/4b87c2a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/9000000/8140000/8132000/8131949/7320679c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/9000000/8140000/8132000/8131949/9bdbe023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/9000000/8140000/8132000/8131949/115e2f73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Magnolia Hotel St. Louis, a Tribute Portfolio Hotel [](https://www.expedia.ca/St-Louis-Hotels-Magnolia-Hotel-St-Louis.h8131949.Hotel-Information) Downtown St. Louis 8.8/10 Excellent (1,264 reviews) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $172 CA $205 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/St-Louis-Hotels-Magnolia-Hotel-St-Louis.h8131949.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/424500/424416/568cd67b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/1000000/430000/424500/424416/ad9bc61a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/424500/424416/d23dbbf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/430000/424500/424416/7e5fcf18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Saint Louis Lafayette Square [](https://www.expedia.ca/St-Louis-Hotels-Hotel-Avyan.h424416.Hotel-Information) The Gate 8.0/10 Very good (296 reviews) "Clean, staff,amenities " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Delilah CA $155 CA $181 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/St-Louis-Hotels-Hotel-Avyan.h424416.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/904800/904712/4c313173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/910000/904800/904712/11973fba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/904800/904712/28e08548.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/910000/904800/904712/146b3f74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott St. Louis Grand [](https://www.expedia.ca/St-Louis-Hotels-Marriott-St-Louis-Grand.h904712.Hotel-Information) Downtown St. Louis 8.2/10 Very good (1,000 reviews) "Everything is excellent. Always a good stay here." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carolyn CA $211 CA $251 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/St-Louis-Hotels-Marriott-St-Louis-Grand.h904712.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/490000/482700/482646/05c66ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/490000/482700/482646/55f436d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/490000/482700/482646/d511e9a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/490000/482700/482646/26e6192d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn St Louis - Troy, IL [](https://www.expedia.ca/St-Louis-Hotels-Red-Roof-Inn-St-Louis-Troy.h482646.Hotel-Information) Troy 7.8/10 Good (1,000 reviews) "Very nice room and very clean, very very comfortable bed, slept amazing, great amenities and bathroom, great rate as well and nice location! Staff were very helpful and friendly as well for our night here! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenden CA $100 CA $111 total includes taxes & fees Apr 13 - Apr 14 [](https://www.expedia.ca/St-Louis-Hotels-Red-Roof-Inn-St-Louis-Troy.h482646.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/450000/446600/446536/7433f47d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/450000/446600/446536/03c2a370.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/450000/446600/446536/fb87bf41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/450000/446600/446536/b28e75cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Troy Hotel [](https://www.expedia.ca/St-Louis-Hotels-Best-Western-Troy-Hotel.h446536.Hotel-Information) Troy 8.2/10 Very good (947 reviews) "Room was clean, staff was friendly, no complaints." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen CA $123 CA $137 total includes taxes & fees Apr 13 - Apr 14 [](https://www.expedia.ca/St-Louis-Hotels-Best-Western-Troy-Hotel.h446536.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-11&endDate=2026-04-12®ionId=6580&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Caseyville Hotel Reviews ![Clayton Plaza Hotel & Extended Stay](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/5c61cbf8_y.jpg) ### Clayton Plaza Hotel & Extended Stay 10/10 Excellent "Room was clean. Staff was nice. Breakfast was top notch. Parking was a little tight for full sized truck but ok. Main downside was a room wasn't available till after 5pm due to short staff. Wasn't aware of $6 a day charge for parking during the week and $50 a night charge for amenities, suppose to be refunded afterwards so waiting to see about that. " [](https://expedia.ca/St-Louis-Hotels-Clayton-Plaza-Hotel-Extended-Stay.h18144.Hotel-Information) ![Renaissance St. Louis Airport Hotel](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/a81cbeae_y.jpg) ### Renaissance St. Louis Airport Hotel 10/10 Excellent "Staff was great. The live music was awesome and our waitress at the restaurant was delightful. The pool was closed and we got no notice before hand. The rooms are tired and in need of some updates, but the beds are very comfortable." [](https://expedia.ca/St-Louis-Hotels-Renaissance-St-Louis-Airport-Hotel.h4672.Hotel-Information) ![The Westin St. Louis](https://images.trvl-media.com/lodging/1000000/470000/460400/460354/665259c4_y.jpg) ### The Westin St. Louis 8/10 Good "Always a good stay at the Westin" [](https://expedia.ca/St-Louis-Hotels-The-Westin-St-Louis.h460354.Hotel-Information) ![Pear Tree Inn St. Louis Airport](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2_y.jpg) ### Pear Tree Inn St. Louis Airport 8/10 Good "Neat, clean, cool, mostly quiet (though next to both the airport and freeway), and welcoming. Staff were very friendly. BBQ restaurant in same parking lot was delicious and convenient. Evening reception was limited to chips and salsa and pretzels; your 2 free drinks are 1/2 glass of wine each. Soda was also available. Breakfast was the same each day: waffles, eggs, sausage, biscuits & gravy, cereals, juice, coffee, soda. There was a persistent strong smell of marijuana smoke being piped through the building's air exchange on the end of the building farthest from the lobby during my entire stay; they really need to install better filters on this system, and/or relocate their smoking areas. The same air exchange system (in the hallway) emits a persistent, intermittent mechanical whine, shutting off for 1-2 seconds every 10-15 seconds; this made sleep difficult." [](https://expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) ![Pear Tree Inn St. Louis Near Union Station](https://images.trvl-media.com/lodging/1000000/30000/26600/26572/3056142b_y.jpg) ### Pear Tree Inn St. Louis Near Union Station 8/10 Good "Tv don’t work both nights. Ice machine didn’t work either day" [](https://expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Near-Union-Station.h26572.Hotel-Information) ![Drury Plaza Hotel St. Louis at the Arch](https://images.trvl-media.com/lodging/1000000/550000/546300/546271/e43b9580_y.jpg) ### Drury Plaza Hotel St. Louis at the Arch 10/10 Excellent "Great hotel, friendly staff, convenient location! Lots of choices on their breakfast buffet. Highly recommend this hotel!" [](https://expedia.ca/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-At-The-Arch.h546271.Hotel-Information) ![Drury Inn & Suites St. Louis Union Station](https://images.trvl-media.com/lodging/1000000/40000/37700/37651/151222b4_y.jpg) ### Drury Inn & Suites St. Louis Union Station 8/10 Good "The staff was wonderful for breakfast and kick back! I wish there were jars to tip. They were so friendly and kept things so clean and nice. " [](https://expedia.ca/St-Louis-Hotels-Drury-Inn-St-Louis-At-Union-Station.h37651.Hotel-Information) ![Hilton St. Louis Airport](https://images.trvl-media.com/lodging/1000000/10000/7800/7743/c57dfbd2_y.jpg) ### Hilton St. Louis Airport 10/10 Excellent "Perfect Hotel to stay before flying out of Lambert" [](https://expedia.ca/St-Louis-Hotels-Hilton-St-Louis-Airport.h7743.Hotel-Information) ![Hotel Indigo St Louis - Central West End by IHG](https://images.trvl-media.com/lodging/1000000/30000/22100/22068/bd89b9ce_y.jpg) ### Hotel Indigo St Louis - Central West End by IHG 10/10 Excellent "Clean room and good staff." [](https://expedia.ca/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-Central-West-End.h22068.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Caseyville cost? ### What are the best business-friendly hotels in Caseyville? ### How many business-friendly hotels are there in Caseyville? ### Are there any family-friendly hotels in Caseyville that are also business friendly? ### Why book your business-friendly hotel in Caseyville with Expedia? ### How can I find cheap business-friendly hotels in Caseyville? ### What is there to do in Caseyville near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [2 Star Hotels in O'Fallon ](https://www.expedia.ca/2Star-OFallon-Hotels.s20-0-d7403.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Collinsville ](https://www.expedia.ca/3Star-Collinsville-Hotels.s30-0-d7352.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Belleville ](https://www.expedia.ca/5Star-Belleville-Hotels.s50-0-d55581.Travel-Guide-Filter-Hotels) - 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