Title: Book the Best Casco Bay Islands LUXURY Hotels - Upscale Hotels in Casco Bay Islands, ME | Expedia.ca [Casco Bay Islands Travel Guide](https://expedia.ca/Casco-Bay-Islands.dx553248621532668098)[Hotels in Casco Bay Islands](https://expedia.ca/Casco-Bay-Islands-Hotels.d553248621532668098.Travel-Guide-Hotels)[Vacation Rentals in Casco Bay Islands](https://expedia.ca/Casco-Bay-Islands-Vacation-Rentals.d553248621532668098.Travel-Guide-VacationRentals)[Flights to Casco Bay Islands](https://expedia.ca/Cheap-Flights-To-Casco-Bay-Islands.d553248621532668098.Travel-Guide-Flights)[Casco Bay Islands Car Rentals](https://expedia.ca/Car-Rentals-In-Casco-Bay-Islands.d553248621532668098.Car-Rental-Guide)[Casco Bay Islands Vacation Packages](https://expedia.ca/Casco-Bay-Islands.d553248621532668098.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/e4a6b1b412662f557ec45267f6320f34.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Casco Bay Islands, ME ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Casco Bay Islands Luxury Hotels Tonight [Oct 29 - Oct 30](https://www.expedia.ca/Hotel-Search?regionId=553248621532668098&startDate=2025-10-29&endDate=2025-10-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Oct 30 - Oct 31](https://www.expedia.ca/Hotel-Search?regionId=553248621532668098&startDate=2025-10-30&endDate=2025-10-31&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248621532668098&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248621532668098&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Casco Bay Islands Luxury Hotels ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/10000000/9710000/9709500/9709454/f8431270.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/10000000/9710000/9709500/9709454/bf9051d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch served](https://images.trvl-media.com/lodging/10000000/9710000/9709500/9709454/0305b790.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby](https://images.trvl-media.com/lodging/10000000/9710000/9709500/9709454/cd488d55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn at Diamond Cove Portland 8.8/10 Excellent (195) "Great rooms and staff and local restaurants. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alan [](https://www.expedia.ca/Portland-Hotels-Inn-At-Diamond-Cove.h9709454.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-12&endDate=2025-11-13®ionId=553248621532668098&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Casco Bay Islands Hotel Reviews ![DoubleTree by Hilton Hotel Portland](//images.trvl-media.com/lodging/1000000/10000/8200/8166/33bb60f2_y.jpg) ### DoubleTree by Hilton Hotel Portland 10/10 Excellent "Hotel beds are very comfortable. The hotel was quiet and conveniently located with lots of options for shopping and eatery." [](https://expedia.ca/Portland-Hotels-DoubleTree-By-Hilton-Hotel-Portland.h8166.Hotel-Information) ![Portland Harbor Hotel](//images.trvl-media.com/lodging/1000000/900000/898700/898621/83fe4590_y.jpg) ### Portland Harbor Hotel 10/10 Excellent "Amazing location, unique hotel with beautiful decor and amenities " [](https://expedia.ca/Portland-Hotels-Portland-Harbor-Hotel.h898621.Hotel-Information) ![Clarion Hotel Portland](//images.trvl-media.com/lodging/1000000/10000/7200/7171/b163ad24_y.jpg) ### Clarion Hotel Portland 10/10 Excellent "The Clarion was excellent for my trip. Located close to airport and to downtown and priced reasonably." [](https://expedia.ca/Portland-Hotels-Clarion-Hotel-Portland.h7171.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Portland DT/Maine Med](//images.trvl-media.com/lodging/1000000/30000/23500/23500/8325dcb5_y.jpg) ### La Quinta Inn & Suites by Wyndham Portland DT/Maine Med 10/10 Excellent "The room was good, the front desk staff friendly. Breakfast was OK, not great, compared with other La Quinta stays." [](https://expedia.ca/Portland-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Portland.h23500.Hotel-Information) ![Hampton Inn Portland Downtown - Waterfront](//images.trvl-media.com/lodging/5000000/4490000/4480300/4480291/1dc67cbc_y.jpg) ### Hampton Inn Portland Downtown - Waterfront 10/10 Excellent "Nice room good linens and good bathroom. Great location and easy but expensive parking " [](https://expedia.ca/Portland-Hotels-Hampton-Inn-Portland-Downtown-Waterfront.h4480291.Hotel-Information) ![Holiday Inn Portland-By the Bay by IHG](//images.trvl-media.com/lodging/1000000/20000/12000/11991/e922ee9f_y.jpg) ### Holiday Inn Portland-By the Bay by IHG 10/10 Excellent "Great staff" [](https://expedia.ca/Portland-Hotels-Holiday-Inn-Portland-By-The-Bay.h11991.Hotel-Information) ![Comfort Inn Airport](//images.trvl-media.com/lodging/1000000/30000/27100/27041/e9231d1b_y.jpg) ### Comfort Inn Airport 10/10 Excellent "Room was great, bed very comfortable, room was quite clean and pet was allowed. That's a big plus!" [](https://expedia.ca/Portland-Hotels-Comfort-Inn-Airport.h27041.Hotel-Information) ![Ramada Plaza by Wyndham Portland](//images.trvl-media.com/lodging/1000000/10000/3000/2908/f5509e04_y.jpg) ### Ramada Plaza by Wyndham Portland 10/10 Excellent "That was friendly made sure everything was taken care of" [](https://expedia.ca/Portland-Hotels-Ramada-Plaza-By-Wyndham-Portland.h2908.Hotel-Information) ![Portland Regency Hotel & Spa](//images.trvl-media.com/lodging/1000000/930000/920100/920050/c8a0ec33_y.jpg) ### Portland Regency Hotel & Spa 10/10 Excellent "Shuttle was easy and punctual. 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