Title: Book the Best ADVENTURE Hotels in Cape Girardeau in 2026 | Expedia.ca [Cape Girardeau Travel Guide](https://expedia.ca/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Vacation Rentals in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)[Flights to Cape Girardeau](https://expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Cape Girardeau Car Rentals](https://expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)[Cape Girardeau Vacation Packages](https://expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides) ![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Alice Burghart # Find Hotels & Resorts for Couples in Cape Girardeau, MO from CA $279 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cape Girardeau Hotels & Resorts for Couples Tonight [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-12-12&endDate=2025-12-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-12-13&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Cape Girardeau adventure hotels ![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/0e13dd89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/564d6e43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Serenity South -- Gardens, River-Views, and Refreshing Space [](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information) Cape Girardeau 10/10 Exceptional (148) "Such a great place and location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy H. CA $207 CA $337 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/d22aee4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, DVD player](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/ded6701c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/12dcf221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/b0f0a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rest, Relax and Renew. Our log cabin experience awaits your arrival. [](https://www.expedia.ca/Anna-Hotels-Rest.h31189922.Hotel-Information) Anna 10/10 Exceptional (403) "Very clean, courteus staff. Beautiful area and quiet. Very relaxing." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tommy CA $161 CA $279 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Anna-Hotels-Rest.h31189922.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/f8286145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/63184534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/4f18c4a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/8a8ad86a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away! [](https://www.expedia.ca/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information) Makanda 9.6/10 Exceptional (39) "The cabin was perfect for our 5 nights in the area. There was plenty of room and everything we needed. The pictures online were nice but in real life, it was a real gem. Can't wait to visit again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Victoria H. CA $150 CA $293 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/35000000/34530000/34529000/34528901/d6ab8f51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Romantic Cottage, 1 King Bed, Non Smoking (Indigo Cottage) | Living area](https://images.trvl-media.com/lodging/35000000/34530000/34529000/34528901/addd1b66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Cottage, Multiple Beds, Non Smoking (West End Cottage) | Living area](https://images.trvl-media.com/lodging/35000000/34530000/34529000/34528901/b59945fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34530000/34529000/34528901/5b224348.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Makanda Inn [](https://www.expedia.ca/Carbondale-Hotels-Makanda-Inn-Cottages.h34528901.Hotel-Information) Makanda 10/10 Exceptional (33) "I had a great stay - wonderful hosts and yummy breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie CA $438 CA $500 total includes taxes & fees Dec 13 - Dec 14 [](https://www.expedia.ca/Carbondale-Hotels-Makanda-Inn-Cottages.h34528901.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27®ionId=820&adults=2&nearby_group=recreation&sort=RECOMMENDED&openPlayBack=true) ## Top Cape Girardeau Hotel Reviews ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 10/10 Excellent "We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. " [](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ## Frequently asked questions ### How much do hotels for couples in Cape Girardeau cost? ### What are the best hotels for couples in Cape Girardeau? ### How many hotels for couples are there in Cape Girardeau? ### Why book your hotel for couples in Cape Girardeau with Expedia? ### How can I find cheap hotels for couples in Cape Girardeau? ### What is there to do in Cape Girardeau near my hotel for couples? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [B&B in Advance ](https://www.expedia.ca/Advance-Bed-And-Breakfast.d553248634983475122-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cheap Hotels in Advance ](https://www.expedia.ca/Advance-Hotels-Cheap-Hotels.0-0-d553248634983475122-tCheapHotels.Travel-Guide-Filter-Hotels) - [Advance Hotels ](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels) - 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