Title: Hotels by La Quinta Inn & Suites in Byron from CA $113 | Expedia.ca [Byron Travel Guide](https://expedia.ca/Byron.dx553248623858895563)[Hotels in Byron](https://expedia.ca/Byron-Hotels.d553248623858895563.Travel-Guide-Hotels)[Vacation Rentals in Byron](https://expedia.ca/Byron-Vacation-Rentals.d553248623858895563.Travel-Guide-VacationRentals)[Flights to Byron](https://expedia.ca/Cheap-Flights-To-Byron.d553248623858895563.Travel-Guide-Flights)[Byron Car Rentals](https://expedia.ca/Car-Rentals-In-Byron.d553248623858895563.Car-Rental-Guide)[Byron Vacation Packages](https://expedia.ca/Byron.d553248623858895563.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Feb 16 - Feb 17](https://www.expedia.ca/Hotel-Search?regionId=553248623858895563&startDate=2026-02-16&endDate=2026-02-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 17 - Feb 18](https://www.expedia.ca/Hotel-Search?regionId=553248623858895563&startDate=2026-02-17&endDate=2026-02-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=553248623858895563&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=553248623858895563&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Byron La Quinta Inn & Suites ![Front of property](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children's pool](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/adc84b77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/76e5e57e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/dd818bd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S [](https://www.expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) Rochester 7.2/10 Good (1,038 reviews) "Everything was excellent" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara CA $98 CA $113 total includes taxes & fees Feb 21 - Feb 22 [](https://www.expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-03&endDate=2026-03-04®ionId=553248623858895563&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FByron-Hotels-La-Quinta-Inn-Suites.0-0-d553248623858895563--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FByron-Hotels-La-Quinta-Inn-Suites.0-0-d553248623858895563--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) ## Top Byron Hotel Reviews ![Holiday Inn Express Rochester South - Mayo Area by IHG](https://images.trvl-media.com/lodging/3000000/2190000/2185000/2184971/62a372dd_y.jpg) ### Holiday Inn Express Rochester South - Mayo Area by IHG 10/10 Excellent "Clean rooms, great staff, excellent breakfast" [](https://expedia.ca/Rochester-Hotels-Comfort-Suites.h2184971.Hotel-Information) ![Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/b33056f7_y.jpg) ### Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area 10/10 Excellent "Room was nice, staff were exceptional. " [](https://expedia.ca/Rochester-Hotels-Centerstone-Plaza-Hotel-Soldiers-FieldMayo-Clinic-Area.h3556.Hotel-Information) ![Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys](https://images.trvl-media.com/lodging/11000000/10950000/10947300/10947270/9bad372e_y.jpg) ### Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys 10/10 Excellent "Very nice rooms. Staff was great." [](https://expedia.ca/Rochester-Hotels-Fairfield-Inn-Suites-Rochester-Mayo-Clinic-AreaSt-Marys.h10947270.Hotel-Information) ![EVEN Hotel Rochester - Mayo Clinic Area by IHG](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/21638bcd_y.jpg) ### EVEN Hotel Rochester - Mayo Clinic Area by IHG 10/10 Excellent "Friendly atmosphere & great service in the lobby restaurant/bar" [](https://expedia.ca/Rochester-Hotels-Even-Rochester-St-Marys-Area.h59619526.Hotel-Information) ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Great place to stay. Clean rooms. Awesome views. Easy to get to everywhere mayo clinic n everything u could possibly need while there. " [](https://expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "Staff, able to eat to the bar and grill connecting to the motel " [](https://expedia.ca/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Aspen Suites](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/6c7e0658_y.jpg) ### Aspen Suites 10/10 Excellent "Room are very nice. Parking a bit tight and limited. Nice breakfast. They provide a quick meal at supper." [](https://expedia.ca/Rochester-Hotels-Aspen-Suites.h904615.Hotel-Information) ![Hampton Inn Rochester-South](https://images.trvl-media.com/lodging/1000000/20000/16600/16522/f90bd051_y.jpg) ### Hampton Inn Rochester-South 10/10 Excellent "We stayed here last year and both days have been wonderful. Staff is so friendly and helpful, pool area clean and" [](https://expedia.ca/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information) ![Hotel Indigo Rochester – Mayo Clinic Area by IHG](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/48e45010_y.jpg) ### Hotel Indigo Rochester – Mayo Clinic Area by IHG 10/10 Excellent "Comfy beds, relatively quiet, great amenities, restaurant/bar is excellent as well. Always stay there when I have to stay in Rochester." 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