Title: 5 Stars Hotels in South Main, Houston from CA $123 - Find Cheap South Main Hotels With 5 Stars | Expedia.ca [South Main Travel Guide](https://expedia.ca/Houston-South-Main.dx553248635976386992)[Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[South Main Car Rentals](https://expedia.ca/Car-Rentals-In-South-Main.d553248635976386992.Car-Rental-Guide)[South Main Vacations](https://expedia.ca/South-Main.d553248635976386992.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/7fff8623dc31b090fdc6a6747a27a07c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Hazem Abdul # 5 Stars Hotels in South Main, Houston from CA $123 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Main 5 Star Hotels Tonight [Oct 22 - Oct 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-22&endDate=2025-10-23&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-23&endDate=2025-10-24&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Main 5 Star Hotels ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/d55af368.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/8367604f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Residential Suite | Private kitchenette](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/4c645ca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/0750496e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Post Oak Hotel at Uptown Houston The Galleria 9.6/10 Exceptional (842) "The hotel property is beautiful. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Aimee CA $695 CA $814 total includes taxes & fees Nov 17 - Nov 18 [](https://www.expedia.ca/Houston-Hotels-The-Post-Oak-Hotel-At-Uptown-Houston.h22340244.Hotel-Information) ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/bf3873ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/9821c0bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/42b4edb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/cd32fa2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel Houston Downtown Houston 9.2/10 Wonderful (1001) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bobby CA $743 CA $876 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Houston-Hotels-Four-Seasons-Hotel-Houston.h20193.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/75cdec53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking | Lounge](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/60772027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/fde99bcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/506faf1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### JW Marriott Houston Downtown Downtown Houston 9.0/10 Wonderful (1010) "Love the room very kind personal at the check in. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Antonia CA $268 CA $323 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/Houston-Hotels-JW-Marriott-Houston-Downtown.h7301257.Hotel-Information) ![Lunch and dinner served, Chinese cuisine](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/cc0b23d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/d6a44ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/e7547f50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, desk, blackout drapes](https://images.trvl-media.com/lodging/2000000/1160000/1156000/1155962/2eba3fa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ACP Hotel Houston Westchase, MOD Collection by Sonesta Sharpstown 8.0/10 Very good (1000) "It's close to everything and free parking ,we enjoyed staying there " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karima CA $105 CA $123 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Houston-Hotels-ACP-Hotel-Westchase.h1155962.Hotel-Information) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/31bacfbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/1ff77d59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/d5969644.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/eab2d50e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The St. Regis Houston The Galleria 9.2/10 Wonderful (399) "Fantastic staff and service " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Rishi CA $655 CA $781 total includes taxes & fees Nov 20 - Nov 21 [](https://www.expedia.ca/Houston-Hotels-The-St-Regis-Houston.h14958.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/4d94e615.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/2fc8cb04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/82c285ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Modern European cuisine](https://images.trvl-media.com/lodging/67000000/66960000/66954200/66954154/458c38c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Colombe d'Or Hotel Montrose 9.2/10 Wonderful (135) "Staff were so friendly & accommodating. Thoroughly enjoyed our stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elaine CA $607 CA $710 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/Houston-Hotels-La-Colombe-DOr-Hotel-Restaurant.h66954154.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/587b4f3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/ba2f1806.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Apartment | Living area](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/ed4d8344.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Apartment | Private kitchen](https://images.trvl-media.com/lodging/97000000/96250000/96248300/96248257/2b83a530.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 7550 Kirby Dr Braeswood Place 8.2/10 Very good (45) "I enjoyed my stay it was worth it" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yontee [](https://www.expedia.ca/Houston-Hotels-7550-Kirby-Dr.h96248257.Hotel-Information) ![Luxury Villa | Living area](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/b59486b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/5026bc67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa | Private kitchen](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/d83b1ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa](https://images.trvl-media.com/lodging/91000000/90880000/90879400/90879356/6257d303.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TUSCAN VILLA Greater Uptown 2.0/10 (3) "Would not recommend . We booked on the same day as check in, no one would answer the phone or let you into the property without 72 hours notice. We purchased the Villa for one night due to a flight cancellation, tried phoning multiple times and messaging before check in closed but no one would answer the phone. We couldn’t stay at the property because we had no information on how to get in. We were charged full price and no refund given, I suggest you book somewhere else that has better... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James [](https://www.expedia.ca/Houston-Hotels-TUSCAN-VILLA.h90879356.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-South-Main-Houston-Hotels.s50-n553248635976386992-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-South-Main-Houston-Hotels.s50-n553248635976386992-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in South Main. ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 5353 Westheimer Rd, Houston, TX CA $165 CA $195 total Nov 20 - Nov 21 includes taxes & fees 8.2/10 Very Good! (2,718 reviews) [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information) ![Club Quarters Hotel Downtown, Houston](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Club Quarters Hotel Downtown, Houston 1085 Rusk Street, Houston, TX CA $138 CA $162 total Oct 23 - Oct 24 includes taxes & fees 8.4/10 Very Good! (3,807 reviews) [](https://expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![Hotel Zaza Houston Museum District](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/47c5ade4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Zaza Houston Museum District 5701 Main Street, Houston, TX CA $372 CA $496 total Oct 23 - Oct 24 includes taxes & fees 8.8/10 Excellent! (1,797 reviews) [](https://expedia.ca/Houston-Hotels-Hotel-Zaza-Houston-Museum-District.h3306.Hotel-Information) Still don't see what you're looking for? [See all properties in South Main.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F10%2F2025&endDate=24%2F10%2F2025®ionId=553248635976386992&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F10%2F2025&endDate=24%2F10%2F2025®ionId=553248635976386992&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F10%2F2025&endDate=24%2F10%2F2025®ionId=553248635976386992&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F10%2F2025&endDate=24%2F10%2F2025®ionId=553248635976386992&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F10%2F2025&endDate=24%2F10%2F2025®ionId=553248635976386992&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F10%2F2025&endDate=24%2F10%2F2025®ionId=553248635976386992&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. 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[Hotels near Texas Children's Hospital](https://www.expedia.ca/Texas-Childrens-Hospital-Hotels.0-l553248635389801905-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Cheap-Hotels.0-n6143504-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Family-Hotel.0-n6143504-0-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Hotel-With-Pool.0-n6143504-0-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Hotels-With-Free-Airport-Shuttle.0-n6143504-0-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Free Breakfast in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Hotels-With-Free-Breakfast.0-n6143504-0-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - 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[Flights from Seattle to Southwest Houston](https://www.expedia.ca/lp/flights/178307/6189441/seattle-to-southwest-houston) - [Visit Astrodome](https://www.expedia.ca/Houston-Astrodome.dx553248635976007975) - [Visit Southside Place](https://www.expedia.ca/Houston-Southside-Place.dx160529) - [Visit Texas Medical Center](https://www.expedia.ca/Houston-Texas-Medical-Center.dx6143504) - [Md Anderson Cancer Center](https://www.expedia.ca/MD-Anderson-Cancer-Center-Texas-Medical-Center.d6248539.Vacation-Attraction) - [Nrg Stadium](https://www.expedia.ca/NRG-Stadium-Astrodome.d553248635929331916.Vacation-Attraction) - [Alamo Rent A Car Rental Cars in Southwest Houston](https://www.expedia.ca/Alamo-Rent-A-Car-Car-Rentals-In-Southwest-Houston.d6189441-c6.Car-Rental-Guide-Suppliers) - [Global Rent a Car Rental Cars in Southwest Houston](https://www.expedia.ca/Global-Rent-A-Car-Car-Rentals-In-Southwest-Houston.d6189441-c1062.Car-Rental-Guide-Suppliers) - [Goldcar Key’n Go Rental Cars in Southwest Houston](https://www.expedia.ca/Goldcar-Keyn-Go-Car-Rentals-In-Southwest-Houston.d6189441-c1044.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Southwest Houston](https://www.expedia.ca/Hertz-Car-Rentals-In-Southwest-Houston.d6189441-c40.Car-Rental-Guide-Suppliers) - [Localiza Rental Cars in Southwest Houston](https://www.expedia.ca/Localiza-Car-Rentals-In-Southwest-Houston.d6189441-c1063.Car-Rental-Guide-Suppliers) - [Locauto Rental Cars in Southwest Houston](https://www.expedia.ca/Locauto-Car-Rentals-In-Southwest-Houston.d6189441-c1140.Car-Rental-Guide-Suppliers) - [Book Hotels in South Main on Expedia.com](https://www.expedia.com/5Star-South-Main-Houston-Hotels.s50-n553248635976386992-0.Travel-Guide-Filter-Hotels)