Title: 5 Stars Hotels in Serra Mesa, San Diego from CA $263 - Find Cheap Serra Mesa Hotels With 5 Stars | Expedia.ca [Serra Mesa Travel Guide](https://expedia.ca/San-Diego-Serra-Mesa.dx553248635953501652)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Serra Mesa, San Diego from CA $263 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Serra Mesa 5 Star Hotels Tonight [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-19&endDate=2025-10-20&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 20 - Oct 21](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-20&endDate=2025-10-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Serra Mesa 5 Star Hotels ![3 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/917a1c42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Body treatments, deep-tissue massages, Swedish massages](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/ffc5e031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/0c2ef40d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pendry San Diego Downtown San Diego 9.2/10 Wonderful (1019) "Great location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christian CA $363 CA $495 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/e71c0bc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/d6c34b55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/61ab8b94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 Bedroom](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/10ea342c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The US Grant, a Luxury Collection Hotel, San Diego Downtown San Diego 9.0/10 Wonderful (1002) "The staff was excellent and attentive. It was centrally located to all we wished to visit" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charles CA $390 CA $452 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/2994db0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/149c7006.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/a51da4df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/6b1cc62f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### L'Auberge Del Mar Del Mar 8.8/10 Excellent (813) "The staff were wonderful. The hotel was immaculate in a beautiful setting. And the hotel valet were super efficient and made coming and going super easy." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lorena CA $559 CA $730 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Del-Mar-Hotels-LAuberge-Del-Mar.h5079.Hotel-Information) ![Outdoor pool, pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/998bcad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/087d6b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/4493b3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Blacker)](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/9d86fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lodge at Torrey Pines Torrey Pines 9.2/10 Wonderful (861) "Excellent hotel and property with gorgeous views and top-notch service." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Harpal CA $595 CA $782 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/La-Jolla-Hotels-The-Lodge-At-Torrey-Pines.h28264.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1780000/1779800/1779742/d14e7124.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1780000/1779800/1779742/w1438h612x0y0-fcfb6510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/2000000/1780000/1779800/1779742/9ab7bf07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1780000/1779800/1779742/d7a843a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairmont Grand Del Mar Carmel Valley 9.6/10 Exceptional (903) "Amazing Hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizaveta CA $559 CA $757 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/San-Diego-Hotels-Fairmont-Grand-Del-Mar.h1779742.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/fe94f9f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/2b448002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/178c1eb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, ocean views ](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/889d28b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bower Coronado Historic Downtown Coronado 9.2/10 Wonderful (119) "Great hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Louie CA $260 CA $356 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Coronado-Hotels-The-Bower.h111958344.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/469088ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/2fa88ae8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/66a30957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/dd10c38e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn At Rancho Santa Fe Covenant 9.6/10 Exceptional (130) "Highly recommend a stay here!! Such a beautiful property with incredible amenities!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ryann CA $630 CA $704 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/Rancho-Santa-Fe-Hotels-Inn-At-Rancho-Santa-Fe.h15525.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/eaeb791a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, down comforters, in-room safe](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/e0260017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/e17e30fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed (Horizon Suite) | Living area](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/bf3cf5a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beach Village at The Del, LXR Hotels & Resorts Historic Downtown Coronado 9.2/10 Wonderful (118) "Best place I’ve ever stayed " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin CA $1,035 CA $1,210 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/Coronado-Hotels-Beach-Village-At-The-Del.h19656437.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/eb69ba1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/e4589e16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/02f2dbb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Hacienda)](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/0e996e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rancho Valencia Resort and Spa Rancho Santa Fe 9.8/10 Exceptional (138) "It was a perfect get away for our anniversary!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sam CA $1,495 CA $1,723 total includes taxes & fees Nov 17 - Nov 18 [](https://www.expedia.ca/Rancho-Santa-Fe-Hotels-Rancho-Valencia-Resort-And-Spa.h17535.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Serra-Mesa-San-Diego-Hotels.s50-n553248635953501652-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Serra-Mesa-San-Diego-Hotels.s50-n553248635953501652-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Serra Mesa. ![Manchester Grand Hyatt San Diego](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/w3840h2092x0y3-447c77a4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Manchester Grand Hyatt San Diego 1 Market Pl, San Diego, CA CA $335 CA $465 total Oct 29 - Oct 30 includes taxes & fees 9/10 Wonderful! (2,855 reviews) [](https://expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![San Diego Marriott La Jolla](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### San Diego Marriott La Jolla 4240 La Jolla Village Dr, La Jolla, CA CA $229 CA $263 total Nov 15 - Nov 16 includes taxes & fees 8.4/10 Very Good! (2,108 reviews) [](https://expedia.ca/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) ![San Diego Marriott Gaslamp Quarter](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/04fbf5a2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### San Diego Marriott Gaslamp Quarter 660 K St, San Diego, CA CA $261 CA $303 total Oct 20 - Oct 21 includes taxes & fees 8.6/10 Excellent! (1,580 reviews) [](https://expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Gaslamp-Quarter.h1466.Hotel-Information) Still don't see what you're looking for? [See all properties in Serra Mesa.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F10%2F2025&endDate=21%2F10%2F2025®ionId=553248635953501652&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F10%2F2025&endDate=21%2F10%2F2025®ionId=553248635953501652&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F10%2F2025&endDate=21%2F10%2F2025®ionId=553248635953501652&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F10%2F2025&endDate=21%2F10%2F2025®ionId=553248635953501652&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F10%2F2025&endDate=21%2F10%2F2025®ionId=553248635953501652&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F10%2F2025&endDate=21%2F10%2F2025®ionId=553248635953501652&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Serra Mesa Hotel Reviews ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "The room was perfect, the shower soap, and lotions smelled so good I bought some to take home. Beautiful hotel and easy to walk around gaslamp without need for uber. Walkable to train and trolly also! The hotel bar was very classy and staff went above and beyond!" [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Serra Mesa? > How much you pay for a 5-star hotel in Serra Mesa can vary depending on when you prefer to travel and how long you plan to stay, among a range of factors. Use our price per night filter and other search tools to find the best deal on a luxurious getaway. > > > > - Search for the lowest price per night from CA $263 ### What makes a hotel 5 stars in Serra Mesa? > Exemplary guest service is at the heart of every 5-star hotel in Serra Mesa. From the instant you arrive, staff attend to your every whim, whether arranging customized tours or providing a nightly turn-down service. On top of that, hotels must feature superior conveniences to be considered for a 5-star rating. These can include deluxe baths, saunas or spas, swimming pools, fine dining restaurants and knowledgeable concierge. ### Are there any 5-star all-inclusive resorts in Serra Mesa? > Find an upscale retreat that includes your lodging, food, activities and entertainment in Serra Mesa with the help of our filter tool. Search for resorts with a 5-star rating and select the "All inclusive" filter. Be sure to check what's included in the price. 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