Title: 5 Stars Hotels in Serra Mesa, San Diego from CA $234 - Find Cheap Serra Mesa Hotels With 5 Stars | Expedia.ca [Serra Mesa Travel Guide](https://expedia.ca/San-Diego-Serra-Mesa.dx553248635953501652)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Aerial view of house in Serra Mesa City in San Diego, California, USA. Green Dry Valley and Villas](https://images.trvl-media.com/place/553248635953501652/8894c002-237b-4878-9643-a4c10cba19ad.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635953501652/8894c002-237b-4878-9643-a4c10cba19ad.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Serra Mesa 5 Star Hotels Tonight [Jan 30 - Jan 31](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2026-01-30&endDate=2026-01-31&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 31 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2026-01-31&endDate=2026-02-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2026-01-30&endDate=2026-02-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Serra Mesa 5-star hotels ![3 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/917a1c42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/0c830a38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05e1c8e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pendry San Diego [](https://www.expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) Downtown San Diego 9.2/10 Wonderful (1,005 reviews) "Superb hotel. Well.positioned with very friendly staff " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) John CA $398 CA $532 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/c54da7f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/7b5917a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/f66e610b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/b1e01344.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The US Grant, a Luxury Collection Hotel, San Diego [](https://www.expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (1,002 reviews) "Staff was very welcoming. Room was clean and large. Only negative is reservation said city view and our view was an old building across street that was empty, perhaps receiving some rehab. I guess that was the view of the city, but i inferred city view on reservation suggested our room would have a nice view of the city. Probably my mistake. OUR stay at the grant was very nice. We enjoyed it. People were great. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Zachary CA $383 CA $445 total includes taxes & fees Feb 16 - Feb 17 [](https://www.expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/2994db0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/6c1670e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/75700d92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/a8b9e4bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### L'Auberge Del Mar [](https://www.expedia.ca/Del-Mar-Hotels-LAuberge-Del-Mar.h5079.Hotel-Information) Del Mar 8.8/10 Excellent (832 reviews) "The location was beautiful. Staff was very friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Quynh N CA $538 CA $710 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Del-Mar-Hotels-LAuberge-Del-Mar.h5079.Hotel-Information) ![Outdoor pool, pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/998bcad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/4493b3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/9de65576.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/087d6b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lodge at Torrey Pines [](https://www.expedia.ca/La-Jolla-Hotels-The-Lodge-At-Torrey-Pines.h28264.Hotel-Information) Torrey Pines 9.2/10 Wonderful (892 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joshua Steven CA $744 CA $949 total includes taxes & fees Feb 16 - Feb 17 [](https://www.expedia.ca/La-Jolla-Hotels-The-Lodge-At-Torrey-Pines.h28264.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510728/2eb0f361.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, individually furnished](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510728/e90f4e82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510728/5873ef1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510728/w3840h2877x0y3-c3d52563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Shore House at The Del, LXR Hotels & Resorts [](https://www.expedia.ca/Coronado-Hotels-Shore-House-At-The-Del.h76510728.Hotel-Information) Historic Downtown Coronado 9.2/10 Wonderful (120 reviews) "What a beautiful place. We had the best room with an incredible view of the ocean. The staff was very friendly and helpful. We will definitely return." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charles CA $774 CA $927 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Coronado-Hotels-Shore-House-At-The-Del.h76510728.Hotel-Information) ![Suite, 1 King Bed (Horizon Suite) | Living area](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/bf3cf5a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast, lunch served; local and international cuisine](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/4f08eb26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/86d154e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, coffee/tea maker](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/w3836h2687x3y0-e1dbf80c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beach Village at The Del, LXR Hotels & Resorts [](https://www.expedia.ca/Coronado-Hotels-Beach-Village-At-The-Del.h19656437.Hotel-Information) Historic Downtown Coronado 9.2/10 Wonderful (125 reviews) "Great staff great room. All and all a perfect 10" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel CA $996 CA $1,163 total includes taxes & fees Feb 16 - Feb 17 [](https://www.expedia.ca/Coronado-Hotels-Beach-Village-At-The-Del.h19656437.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/433d1302.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/178c1eb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium King with Orange Ave](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/c381e66d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/2b448002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bower Coronado [](https://www.expedia.ca/Coronado-Hotels-The-Bower.h111958344.Hotel-Information) Historic Downtown Coronado 9.2/10 Wonderful (174 reviews) "We had such a great stay and would recommend this hotel and will continue to stay here!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nico CA $363 CA $467 total includes taxes & fees Feb 16 - Feb 17 [](https://www.expedia.ca/Coronado-Hotels-The-Bower.h111958344.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/efc06bf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/2fa88ae8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/da3d84fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/06f28e7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn At Rancho Santa Fe [](https://www.expedia.ca/Rancho-Santa-Fe-Hotels-Inn-At-Rancho-Santa-Fe.h15525.Hotel-Information) Covenant 9.6/10 Exceptional (142 reviews) "Amazing hotel great service " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica M CA $577 CA $647 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/Rancho-Santa-Fe-Hotels-Inn-At-Rancho-Santa-Fe.h15525.Hotel-Information) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/55395a5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, DVD player, pay movies](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/01ed4f70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/ea6aeb29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/325f3dcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rancho Valencia Resort and Spa [](https://www.expedia.ca/Rancho-Santa-Fe-Hotels-Rancho-Valencia-Resort-And-Spa.h17535.Hotel-Information) Rancho Santa Fe 9.8/10 Exceptional (139 reviews) "It was a perfect get away for our anniversary!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sam CA $1,391 CA $1,608 total includes taxes & fees Feb 3 - Feb 4 [](https://www.expedia.ca/Rancho-Santa-Fe-Hotels-Rancho-Valencia-Resort-And-Spa.h17535.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Serra-Mesa-San-Diego-Hotels.s50-n553248635953501652-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Serra-Mesa-San-Diego-Hotels.s50-n553248635953501652-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Serra Mesa. ![Hotel del Coronado, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel del Coronado, Curio Collection by Hilton 1500 Orange Ave Coronado CA CA $675 CA $825 total Feb 12 - Feb 13 includes taxes & fees 8.4/10 Very Good! (1,010 reviews) [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hard Rock Hotel San Diego 207 5th Ave San Diego CA CA $232 CA $334 total Feb 1 - Feb 2 includes taxes & fees 8.8/10 Excellent! (3,270 reviews) [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 7450 Hazard Center Dr San Diego CA CA $204 CA $234 total Feb 25 - Feb 26 includes taxes & fees 8.2/10 Very Good! (1,511 reviews) [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) Still don't see what you're looking for? [See all properties in Serra Mesa.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F02%2F2026&endDate=02%2F02%2F2026®ionId=553248635953501652&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F02%2F2026&endDate=02%2F02%2F2026®ionId=553248635953501652&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F02%2F2026&endDate=02%2F02%2F2026®ionId=553248635953501652&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F02%2F2026&endDate=02%2F02%2F2026®ionId=553248635953501652&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F02%2F2026&endDate=02%2F02%2F2026®ionId=553248635953501652&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F02%2F2026&endDate=02%2F02%2F2026®ionId=553248635953501652&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Serra Mesa Hotel Reviews ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Serra Mesa? > - Search for the lowest price per night from CA $234 ### What makes a hotel 5 stars in Serra Mesa? ### Are there any 5-star all-inclusive resorts in Serra Mesa? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [1 Star Hotels in San Diego ](https://www.expedia.ca/1Star-San-Diego-Hotels.s10-0-d3073.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Lincoln Park ](https://www.expedia.ca/2Star-Lincoln-Park-San-Diego-Hotels.s20-n797413695373639680-0.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Pacific Beach ](https://www.expedia.ca/2Star-Pacific-Beach-San-Diego-Hotels.s20-n6185751-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Downtown San Diego ](https://www.expedia.ca/3Star-Downtown-San-Diego-San-Diego-Hotels.s30-n800123-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Gaslamp Quarter ](https://www.expedia.ca/3Star-Gaslamp-Quarter-San-Diego-Hotels.s30-n6130021-0.Travel-Guide-Filter-Hotels) - 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