Title: 5 Stars Hotels in Serra Mesa, San Diego from CA $233 - Find Cheap Serra Mesa Hotels With 5 Stars | Expedia.ca [Serra Mesa Travel Guide](https://expedia.ca/San-Diego-Serra-Mesa.dx553248635953501652)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Serra Mesa, San Diego from CA $233 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Serra Mesa 5 Star Hotels Tonight [Nov 3 - Nov 4](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-11-03&endDate=2025-11-04&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-11-04&endDate=2025-11-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-11-14&endDate=2025-11-16&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Serra Mesa 5 Star Hotels ![3 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/917a1c42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Body treatments, deep-tissue massages, Swedish massages](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/ffc5e031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/0c2ef40d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pendry San Diego Downtown San Diego 9.2/10 Wonderful (1002) "Great location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christian CA $350 CA $480 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/e71c0bc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/61ab8b94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/d6c34b55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 Bedroom](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/10ea342c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The US Grant, a Luxury Collection Hotel, San Diego Downtown San Diego 9.0/10 Wonderful (1004) "The food for both room service and in house dining was OUTSTANDING! Staff was just lovely. Walking around outside with the homeless problem, not so great. Overall wonderful hotel, though!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rick R CA $364 CA $423 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/2994db0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/6b1cc62f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/a51da4df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/149c7006.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### L'Auberge Del Mar Del Mar 8.8/10 Excellent (815) "Top tier service and location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sherry CA $559 CA $729 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Del-Mar-Hotels-LAuberge-Del-Mar.h5079.Hotel-Information) ![Outdoor pool, pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/998bcad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/4493b3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Blacker)](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/9d86fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/28300/28264/087d6b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lodge at Torrey Pines Torrey Pines 9.2/10 Wonderful (863) "Wonderful stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly CA $656 CA $852 total includes taxes & fees Nov 17 - Nov 18 [](https://www.expedia.ca/La-Jolla-Hotels-The-Lodge-At-Torrey-Pines.h28264.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1780000/1779800/1779742/d14e7124.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/2000000/1780000/1779800/1779742/9ab7bf07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1780000/1779800/1779742/d7a843a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1780000/1779800/1779742/b12af9a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairmont Grand Del Mar Carmel Valley 9.6/10 Exceptional (907) "We spent 3 days here at this wonderful hotel. Amazing experience and we will be returning most definitely! " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Paul CA $559 CA $757 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/San-Diego-Hotels-Fairmont-Grand-Del-Mar.h1779742.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/fe94f9f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, ocean views ](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/889d28b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/178c1eb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/2b448002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bower Coronado Historic Downtown Coronado 9.2/10 Wonderful (130) "We had such a nice stay at the bower and we can highly recommend it!" ![Germany](https://a.travel-assets.com/egds/marks/flags/de.svg) Nils CA $260 CA $356 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Coronado-Hotels-The-Bower.h111958344.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/469088ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/d42c797c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/2fa88ae8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/66a30957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn At Rancho Santa Fe Covenant 9.4/10 Exceptional (131) "Beautiful, quaint property" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alicia CA $1,119 CA $1,234 total includes taxes & fees Nov 15 - Nov 16 [](https://www.expedia.ca/Rancho-Santa-Fe-Hotels-Inn-At-Rancho-Santa-Fe.h15525.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/eaeb791a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, down comforters, in-room safe](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/e0260017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed (Horizon Suite) | Living area](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/bf3cf5a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/e17e30fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beach Village at The Del, LXR Hotels & Resorts Historic Downtown Coronado 9.2/10 Wonderful (118) "The Del is amazing! The staff are top notch and the amenities are endless! We cannot wait to go back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Russell CA $1,034 CA $1,209 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Coronado-Hotels-Beach-Village-At-The-Del.h19656437.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/eb69ba1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/e4589e16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/c3df3564.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools](https://images.trvl-media.com/lodging/1000000/20000/17600/17535/02f2dbb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rancho Valencia Resort and Spa Rancho Santa Fe 9.8/10 Exceptional (138) "Tennis courts and staff are top notch. Rooms are very large and luxurious. Staff is super accomodating and make you feel special. All in all, we felt like royalty." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rachel CA $1,509 CA $1,738 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Rancho-Santa-Fe-Hotels-Rancho-Valencia-Resort-And-Spa.h17535.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Serra-Mesa-San-Diego-Hotels.s50-n553248635953501652-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Serra-Mesa-San-Diego-Hotels.s50-n553248635953501652-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Serra Mesa. ![Manchester Grand Hyatt San Diego](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/w3840h2092x0y3-447c77a4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Manchester Grand Hyatt San Diego 1 Market Pl, San Diego, CA CA $251 CA $367 total Nov 25 - Nov 26 includes taxes & fees 9/10 Wonderful! (2,848 reviews) [](https://expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![San Diego Marriott La Jolla](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### San Diego Marriott La Jolla 4240 La Jolla Village Dr, La Jolla, CA CA $229 CA $264 total Nov 8 - Nov 9 includes taxes & fees 8.4/10 Very Good! (2,119 reviews) [](https://expedia.ca/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) ![San Diego Marriott Gaslamp Quarter](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/04fbf5a2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### San Diego Marriott Gaslamp Quarter 660 K St, San Diego, CA CA $201 CA $233 total Nov 20 - Nov 21 includes taxes & fees 8.6/10 Excellent! (1,583 reviews) [](https://expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Gaslamp-Quarter.h1466.Hotel-Information) Still don't see what you're looking for? [See all properties in Serra Mesa.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F11%2F2025&endDate=06%2F11%2F2025®ionId=553248635953501652&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F11%2F2025&endDate=06%2F11%2F2025®ionId=553248635953501652&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F11%2F2025&endDate=06%2F11%2F2025®ionId=553248635953501652&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F11%2F2025&endDate=06%2F11%2F2025®ionId=553248635953501652&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F11%2F2025&endDate=06%2F11%2F2025®ionId=553248635953501652&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F11%2F2025&endDate=06%2F11%2F2025®ionId=553248635953501652&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Serra Mesa Hotel Reviews ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "The rooms were very nice and the location is perfect for San Diego. It's a very nice hotel." [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Serra Mesa? > How much you pay for a 5-star hotel in Serra Mesa can vary depending on when you prefer to travel and how long you plan to stay, among a range of factors. Use our price per night filter and other search tools to find the best deal on a luxurious getaway. > > > > - Search for the lowest price per night from CA $233 ### What makes a hotel 5 stars in Serra Mesa? > Exemplary guest service is at the heart of every 5-star hotel in Serra Mesa. From the instant you arrive, staff attend to your every whim, whether arranging customized tours or providing a nightly turn-down service. On top of that, hotels must feature superior conveniences to be considered for a 5-star rating. These can include deluxe baths, saunas or spas, swimming pools, fine dining restaurants and knowledgeable concierge. ### Are there any 5-star all-inclusive resorts in Serra Mesa? > Find an upscale retreat that includes your lodging, food, activities and entertainment in Serra Mesa with the help of our filter tool. Search for resorts with a 5-star rating and select the "All inclusive" filter. Be sure to check what's included in the price. That way, you're ready to take advantage of all the premium perks from the moment you get there. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [1 Star Hotels in San Diego](https://www.expedia.ca/1Star-San-Diego-Hotels.s10-0-d3073.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Lincoln Park](https://www.expedia.ca/2Star-Lincoln-Park-San-Diego-Hotels.s20-n797413695373639680-0.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Pacific Beach](https://www.expedia.ca/2Star-Pacific-Beach-San-Diego-Hotels.s20-n6185751-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Downtown San Diego](https://www.expedia.ca/3Star-Downtown-San-Diego-San-Diego-Hotels.s30-n800123-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Gaslamp Quarter](https://www.expedia.ca/3Star-Gaslamp-Quarter-San-Diego-Hotels.s30-n6130021-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Mid-City](https://www.expedia.ca/3Star-Mid-City-San-Diego-Hotels.s30-n553248635976388682-0.Travel-Guide-Filter-Hotels) - 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[Flights from Bishop (BIH) to San Diego (MYF)](https://www.expedia.ca/lp/flights/bih/myf/bishop-to-san-diego) - [Flights from Bellingham (BLI) to San Diego (MYF)](https://www.expedia.ca/lp/flights/bli/myf/bellingham-to-san-diego) - [Flights from Boston (BOS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/bos/myf/boston-to-san-diego) - [Flights from Burlington (BTV) to San Diego (MYF)](https://www.expedia.ca/lp/flights/btv/myf/burlington-to-san-diego) - [Flights from Borrego Springs (BXS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/bxs/myf/borrego-springs-to-san-diego) - [Flights from Upland (CCB) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ccb/myf/upland-to-san-diego) - [Flights from College Park (CGS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/cgs/myf/college-park-to-san-diego) - [Flights from Clovis (CVN) to San Diego (MYF)](https://www.expedia.ca/lp/flights/cvn/myf/clovis-to-san-diego) - [Flights from Corvallis (CVO) to San Diego (MYF)](https://www.expedia.ca/lp/flights/cvo/myf/corvallis-to-san-diego) - 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