Title: 5 Stars Hotels in Otay Mesa, San Diego from CA $176 - Find Cheap Otay Mesa Hotels With 5 Stars | Expedia.ca [Otay Mesa Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa.dx6263723)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Otay Mesa, San Diego from CA $176 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Otay Mesa 5 Star Hotels Tonight [Dec 5 - Dec 6](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-05&endDate=2025-12-06&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 6 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-06&endDate=2025-12-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-05&endDate=2025-12-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Otay Mesa 5 Star Hotels ![3 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/0c2ef40d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Body treatments, deep-tissue massages, Swedish massages](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/ffc5e031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Body treatments, deep-tissue massages, Swedish massages](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/a2e0b6aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pendry San Diego Downtown San Diego 9.2/10 Wonderful (1001) "Stunning hotel, delicious restaurants, energizing location and beautiful time! Can’t wait to come back! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa K CA $356 CA $486 total includes taxes & fees Dec 25 - Dec 26 [](https://www.expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/e71c0bc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/w4000h2663x0y0-0937aebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/d6c34b55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 Bedroom](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/10ea342c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The US Grant, a Luxury Collection Hotel, San Diego Downtown San Diego 9.0/10 Wonderful (1002) "I loved my stay here ! I would definitely stay here again . The staff were pleasant and welcoming. The amenities were great ! The only complaint I have is I wish parking was included in our stay if you’re staying at the hotel as a guest " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vanessa CA $343 CA $398 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510728/w3840h2877x0y3-c3d52563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510728/117941b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, individually furnished](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510728/e90f4e82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510728/becfbbfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Shore House at The Del, LXR Hotels & Resorts Historic Downtown Coronado 9.2/10 Wonderful (112) "What a beautiful place. We had the best room with an incredible view of the ocean. The staff was very friendly and helpful. We will definitely return." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charles CA $781 CA $937 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Coronado-Hotels-Shore-House-At-The-Del.h76510728.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/eaeb791a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch Smart TV with cable channels, fireplace, Netflix](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/w3836h2711x3y3-7839679e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed (Horizon Suite) | Living area](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/bf3cf5a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, in-room safe, individually furnished](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/e0260017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beach Village at The Del, LXR Hotels & Resorts Historic Downtown Coronado 9.2/10 Wonderful (120) "Best place I’ve ever stayed " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin CA $1,005 CA $1,177 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Coronado-Hotels-Beach-Village-At-The-Del.h19656437.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/fe94f9f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, ocean views ](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/889d28b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/2b448002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium King with Orange Ave](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/c381e66d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bower Coronado Historic Downtown Coronado 9.2/10 Wonderful (147) "Wonderful service. Great location. Beautiful design. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly CA $288 CA $386 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Coronado-Hotels-The-Bower.h111958344.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Otay-Mesa-San-Diego-Hotels.s50-n6263723-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Otay-Mesa-San-Diego-Hotels.s50-n6263723-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Otay Mesa. ![Hotel del Coronado, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel del Coronado, Curio Collection by Hilton 1500 Orange Ave Coronado CA CA $473 CA $603 total Jan 4 - Jan 5, 2026 includes taxes & fees 8.4/10 Very Good! (1,022 reviews) [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hard Rock Hotel San Diego 207 5th Ave San Diego CA CA $233 CA $335 total Jan 2 - Jan 3, 2026 includes taxes & fees 8.8/10 Excellent! (3,134 reviews) [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 7450 Hazard Center Dr San Diego CA CA $153 CA $176 total Dec 22 - Dec 23 includes taxes & fees 8.2/10 Very Good! (1,379 reviews) [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) Still don't see what you're looking for? [See all properties in Otay Mesa.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F12%2F2025&endDate=07%2F12%2F2025®ionId=6263723&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F12%2F2025&endDate=07%2F12%2F2025®ionId=6263723&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F12%2F2025&endDate=07%2F12%2F2025®ionId=6263723&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F12%2F2025&endDate=07%2F12%2F2025®ionId=6263723&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F12%2F2025&endDate=07%2F12%2F2025®ionId=6263723&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=06%2F12%2F2025&endDate=07%2F12%2F2025®ionId=6263723&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Otay Mesa Hotel Reviews ## Find out more about Otay Mesa ## Five Star Hotels in Otay Mesa There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Otay Mesa so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Otay Mesa and get ready to be pampered like never before. #### Get a Great Deal on 5-Star Hotels in Otay Mesa Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places. Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town. #### Make Your Escape to Otay Mesa The results are in, and Otay Mesa 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Otay Mesa! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Otay Mesa today and settle down in the lap of luxury tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Otay Mesa? > - Search for the lowest price per night from CA $176 ### What makes a hotel 5 stars in Otay Mesa? ### Are there any 5-star all-inclusive resorts in Otay Mesa? ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [1 Star Hotels in San Diego ](https://www.expedia.ca/1Star-San-Diego-Hotels.s10-0-d3073.Travel-Guide-Filter-Hotels) - [1 Star Hotels in San Miguel Ranch ](https://www.expedia.ca/1Star-San-Miguel-Ranch-Chula-Vista-Hotels.s10-n553248635976480437-0.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Lincoln Park ](https://www.expedia.ca/2Star-Lincoln-Park-San-Diego-Hotels.s20-n797413695373639680-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Chula Vista ](https://www.expedia.ca/3Star-Chula-Vista-Hotels.s30-0-d7442.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Downtown San Diego ](https://www.expedia.ca/3Star-Downtown-San-Diego-San-Diego-Hotels.s30-n800123-0.Travel-Guide-Filter-Hotels) - 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