Title: 5 Stars Hotels in Otay Mesa, San Diego from CA $183 - Find Cheap Otay Mesa Hotels With 5 Stars | Expedia.ca [Otay Mesa Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa.dx6263723)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Otay Mesa, San Diego from CA $183 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Otay Mesa 5 Star Hotels Tonight [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-13&endDate=2025-10-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-14&endDate=2025-10-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Otay Mesa 5 Star Hotels ![3 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/917a1c42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Body treatments, deep-tissue massages, Swedish massages](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/ffc5e031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/0c2ef40d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pendry San Diego Downtown San Diego 9.2/10 Wonderful (1017) "Great room and staff, restaurant is also very good " CA $350 CA $480 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/e71c0bc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/d6c34b55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/w4000h2663x0y0-0937aebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/61ab8b94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The US Grant, a Luxury Collection Hotel, San Diego Downtown San Diego 9.0/10 Wonderful (1004) "The staff was excellent and attentive. It was centrally located to all we wished to visit" CA $390 CA $452 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/fe94f9f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/2b448002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, ocean views ](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/889d28b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium King with Orange Ave](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/c381e66d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bower Coronado Historic Downtown Coronado 9.2/10 Wonderful (115) "Great hotel " CA $373 CA $481 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Coronado-Hotels-The-Bower.h111958344.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/eaeb791a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, down comforters, in-room safe](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/e0260017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch Smart TV with cable channels, fireplace, Netflix](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/w3836h2711x3y3-7839679e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed (Horizon Suite) | Living area](https://images.trvl-media.com/lodging/20000000/19660000/19656500/19656437/bf3cf5a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beach Village at The Del, LXR Hotels & Resorts Historic Downtown Coronado 9.2/10 Wonderful (117) "Best place I’ve ever stayed " CA $1,034 CA $1,209 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Coronado-Hotels-Beach-Village-At-The-Del.h19656437.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Otay-Mesa-San-Diego-Hotels.s50-n6263723-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Otay-Mesa-San-Diego-Hotels.s50-n6263723-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Otay Mesa. ![Hotel del Coronado, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel del Coronado, Curio Collection by Hilton 1500 Orange Ave, Coronado, CA CA $458 CA $587 total Oct 29 - Oct 30 includes taxes & fees 8/10 Very Good! (1,013 reviews) [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Wyndham San Diego Bayside 1355 N Harbor Drive, San Diego, CA CA $213 CA $288 total Oct 20 - Oct 21 includes taxes & fees 8.2/10 Very Good! (6,003 reviews) [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Palihotel San Diego Gaslamp Quarter](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/4480f6ef_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Palihotel San Diego Gaslamp Quarter 830 Sixth Avenue, San Diego, CA CA $158 CA $183 total Oct 14 - Oct 15 includes taxes & fees 8.6/10 Excellent! (1,910 reviews) [](https://expedia.ca/San-Diego-Hotels-Palihotel-San-Diego.h88398416.Hotel-Information) Still don't see what you're looking for? [See all properties in Otay Mesa.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F10%2F2025&endDate=15%2F10%2F2025®ionId=6263723&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F10%2F2025&endDate=15%2F10%2F2025®ionId=6263723&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F10%2F2025&endDate=15%2F10%2F2025®ionId=6263723&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F10%2F2025&endDate=15%2F10%2F2025®ionId=6263723&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F10%2F2025&endDate=15%2F10%2F2025®ionId=6263723&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F10%2F2025&endDate=15%2F10%2F2025®ionId=6263723&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Otay Mesa Hotel Reviews ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Staff was so friendly and welcoming. " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ## Find out more about Otay Mesa ## Five Star Hotels in Otay Mesa There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Otay Mesa so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Otay Mesa and get ready to be pampered like never before. #### Get a Great Deal on 5-Star Hotels in Otay Mesa Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places. Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town. #### Make Your Escape to Otay Mesa The results are in, and Otay Mesa 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Otay Mesa! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Otay Mesa today and settle down in the lap of luxury tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Otay Mesa? > The amount you pay for a 5-star hotel in Otay Mesa depends on things like when you want to go and the length of your getaway. Our insider tip for landing an awesome deal? Use our pricing filters to compare all of the available accommodations for your selected dates. > > > > - Search for the lowest price per night from CA $183 ### What makes a hotel 5 stars in Otay Mesa? > From high-end dining venues and all-day gyms to swimming pools and premium bedding, the 5-star experience in Otay Mesa is all about luxury and relaxation. But it takes more than just top-notch perks to receive a 5-star rating. Hotels also have to deliver extraordinary guest services like beauty treatments, on-site laundry and 24-hour concierge services. ### Are there any 5-star all-inclusive resorts in Otay Mesa? > Find a luxury escape that includes your lodging, meals, drinks and entertainment in Otay Mesa with our filters. Search for resorts with a 5-star rating and click on the "All inclusive" filter. Have a look at what's included in the upfront price. 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