Title: 5 Stars Hotels in Mission District, San Francisco from CA $188 - Find Cheap Mission District Hotels With 5 Stars | Expedia.ca [Mission District Travel Guide](https://expedia.ca/San-Francisco-Mission-District.dx134035)[Vacation Rentals in San Francisco](https://expedia.ca/San-Francisco-Vacation-Rentals.d178305.Travel-Guide-VacationRentals)[Flights to San Francisco](https://expedia.ca/Cheap-Flights-To-San-Francisco.d178305.Travel-Guide-Flights)[Things to do in San Francisco](https://expedia.ca/Things-To-Do-In-San-Francisco.d178305.Travel-Guide-Activities)[Mission District Car Rentals](https://expedia.ca/Car-Rentals-In-Mission-District.d134035.Car-Rental-Guide)[Mission District Vacations](https://expedia.ca/Mission-District.d134035.Destination-Travel-Guides) ![Mission District which includes outdoor art](https://images.trvl-media.com/place/134035/1fb7195b-23e3-4a0f-a5ef-22b484069f64.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/134035/1fb7195b-23e3-4a0f-a5ef-22b484069f64.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mission District 5 Star Hotels Tonight [Mar 22 - Mar 23](https://www.expedia.ca/Hotel-Search?regionId=134035&startDate=2026-03-22&endDate=2026-03-23&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 23 - Mar 24](https://www.expedia.ca/Hotel-Search?regionId=134035&startDate=2026-03-23&endDate=2026-03-24&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=134035&startDate=2026-03-27&endDate=2026-03-29&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=134035&startDate=2026-04-03&endDate=2026-04-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mission District 5-star hotels ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/6f6889e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Asian cuisine](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/908b91b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/9872e531.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fairmont Legacy Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/aa9ce76d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairmont San Francisco [](https://www.expedia.ca/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information) Downtown San Francisco 9.0/10 Wonderful (1,491 reviews) "Great staff; nice restaurants. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Robert CA $296 CA $413 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/w4000h2663x0y0-df4f3756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/59a0fd33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/e72fe89a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/ad005a29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palace Hotel, a Luxury Collection Hotel, San Francisco [](https://www.expedia.ca/San-Francisco-Hotels-Palace-Hotel.h27274.Hotel-Information) Downtown San Francisco 9.2/10 Wonderful (1,001 reviews) "Room and hotel were beautiful. Great central location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dave CA $382 CA $449 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/San-Francisco-Hotels-Palace-Hotel.h27274.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/4ff57257.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom (Campton)](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/0d62a8a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/d5b628f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Union Square Deluxe King Bed | City view](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/e55a857c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Taj Campton Place [](https://www.expedia.ca/San-Francisco-Hotels-Taj-Campton-Place.h23383.Hotel-Information) Union Square 9.2/10 Wonderful (1,004 reviews) "It was a perfect stay" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Travel To Explore CA $225 CA $313 total includes taxes & fees Apr 11 - Apr 12 [](https://www.expedia.ca/San-Francisco-Hotels-Taj-Campton-Place.h23383.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/41a2cb6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/91a3ba7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/ac69c36b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, minibar](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/90ac212c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel San Francisco at Embarcadero [](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco-At-Embarcadero.h6505.Hotel-Information) Downtown San Francisco 9.6/10 Exceptional (1,000 reviews) "Very friendly staff and overall had a great visit" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $647 CA $762 total includes taxes & fees Apr 10 - Apr 11 [](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco-At-Embarcadero.h6505.Hotel-Information) ![Breakfast, lunch, dinner served; alfresco dining](https://images.trvl-media.com/lodging/2000000/1140000/1138300/1138217/60488ea7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1140000/1138300/1138217/2335e7c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/2000000/1140000/1138300/1138217/dc2c64db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1140000/1138300/1138217/10cefca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 1 Hotel San Francisco [](https://www.expedia.ca/San-Francisco-Hotels-1-Hotel-San-Francisco.h1138217.Hotel-Information) Downtown San Francisco 9.2/10 Wonderful (522 reviews) "We loved our stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $548 CA $722 total includes taxes & fees Apr 19 - Apr 20 [](https://www.expedia.ca/San-Francisco-Hotels-1-Hotel-San-Francisco.h1138217.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/bff475ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/bd897e6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves breakfast, lunch, and dinner](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/0cd41feb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/ab6ff173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel San Francisco [](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information) Downtown San Francisco 9.4/10 Exceptional (1,001 reviews) " Excellent rooms and staff, terrific food, great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roberta CA $638 CA $751 total includes taxes & fees Apr 3 - Apr 4 [](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/6700/6609/ba76b95f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/6700/6609/w1022h554x1y0-70682131.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![47-inch flat-screen TV with digital channels, Smart TV, table tennis](https://images.trvl-media.com/lodging/1000000/10000/6700/6609/fb1bec56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/6700/6609/76bdc90c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Claremont Resort & Club [](https://www.expedia.ca/Oakland-Hotels-Claremont-Club-Spa-A-Fairmont-Hotel.h6609.Hotel-Information) Claremont Hills 9.0/10 Wonderful (1,004 reviews) "Great stay and property" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather CA $353 CA $489 total includes taxes & fees Apr 1 - Apr 2 [](https://www.expedia.ca/Oakland-Hotels-Claremont-Club-Spa-A-Fairmont-Hotel.h6609.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22200/22148/e3b2f195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/30000/22200/22148/5b42d596.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22200/22148/62f42199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/30000/22200/22148/d50915e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, San Francisco [](https://www.expedia.ca/San-Francisco-Hotels-The-Ritz-Carlton.h22148.Hotel-Information) Downtown San Francisco 9.4/10 Exceptional (1,002 reviews) "Impeccable service, beautiful property, and great food and drinks in the lobby lounge." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $500 CA $655 total includes taxes & fees Apr 10 - Apr 11 [](https://www.expedia.ca/San-Francisco-Hotels-The-Ritz-Carlton.h22148.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/a5681857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 Bedroom](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/45abbb57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/w4000h2662x0y0-41a38e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Corner](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/29f2f698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The St. Regis San Francisco [](https://www.expedia.ca/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information) Downtown San Francisco 9.4/10 Exceptional (713 reviews) "The service was spectacular, enjoyed the restaurant as well as room service, and the room was very clean and spacious " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren CA $517 CA $671 total includes taxes & fees Apr 10 - Apr 11 [](https://www.expedia.ca/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/80000/74200/74183/35b03efd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bicycling](https://images.trvl-media.com/lodging/1000000/80000/74200/74183/4f9a25c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/80000/74200/74183/7c3a3b99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/80000/74200/74183/be4033e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Drisco [](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Drisco.h74183.Hotel-Information) Pacific Heights 9.8/10 Exceptional (460 reviews) "Great hotel and would highly recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Oliver CA $777 CA $904 total includes taxes & fees Apr 6 - Apr 7 [](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Drisco.h74183.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1860000/1853300/1853240/9ae8226d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1860000/1853300/1853240/3fbb1d83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1860000/1853300/1853240/e6f1bfe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1860000/1853300/1853240/6f41305b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairmont Heritage Place, Ghirardelli Square [](https://www.expedia.ca/San-Francisco-Hotels-Fairmont-Heritage-Place.h1853240.Hotel-Information) Fisherman's Wharf 9.4/10 Exceptional (390 reviews) "My family absolutely enjoyed our stay. Wonderful customer service and a great luxury room. Would definitely stay hear again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angel CA $1,173 CA $1,379 total includes taxes & fees Apr 20 - Apr 21 [](https://www.expedia.ca/San-Francisco-Hotels-Fairmont-Heritage-Place.h1853240.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/900/864/25ea6e9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; local cuisine ](https://images.trvl-media.com/lodging/1000000/10000/900/864/3643cf3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/10000/900/864/8b2202a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/1000000/10000/900/864/167bd1f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Huntington Hotel [](https://www.expedia.ca/San-Francisco-Hotels-Huntington-Hotel.h864.Hotel-Information) Downtown San Francisco CA $822 CA $1,040 total includes taxes & fees Apr 3 - Apr 4 [](https://www.expedia.ca/San-Francisco-Hotels-Huntington-Hotel.h864.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/8000000/7070000/7064400/7064385/a415df7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/8000000/7070000/7064400/7064385/fb8da040.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/8000000/7070000/7064400/7064385/66b6828b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/8000000/7070000/7064400/7064385/e534761f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Neighbourgood Sutter Mansion [](https://www.expedia.ca/San-Francisco-Hotels-Mansion-On-Sutter.h7064385.Hotel-Information) Western Addition 9.4/10 Exceptional (237 reviews) "Friendly staff, early 1900s decor and architecture." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Louis [](https://www.expedia.ca/San-Francisco-Hotels-Mansion-On-Sutter.h7064385.Hotel-Information) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90330000/90324300/90324275/bb2d6232.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/91000000/90330000/90324300/90324275/cdc429e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90330000/90324300/90324275/w4322h2866x6y0-3800e1b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90330000/90324300/90324275/3f52aac8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dimond Abode Vacation Rental 3428 [](https://www.expedia.ca/Oakland-Hotels-Dimond-Abode-3428.h90324275.Hotel-Information) Dimond 9.6/10 Exceptional (7 reviews) "Cleanliness, amenities, staff. It was a really great stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Phyllis [](https://www.expedia.ca/Oakland-Hotels-Dimond-Abode-3428.h90324275.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mission-District-San-Francisco-Hotels.s50-n134035-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mission-District-San-Francisco-Hotels.s50-n134035-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mission District. ![Hotel Riu Plaza Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/75f20517_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Riu Plaza Fisherman's Wharf 2500 Mason St San Francisco CA CA $202 CA $294 total Apr 12 - Apr 13 includes taxes & fees 9/10 Wonderful! (7,370 reviews) [](https://expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information) ![DoubleTree by Hilton Hotel Berkeley Marina](https://images.trvl-media.com/lodging/1000000/30000/23800/23800/ba0da8d5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### DoubleTree by Hilton Hotel Berkeley Marina 200 Marina Blvd Berkeley CA CA $163 CA $188 total Mar 29 - Mar 30 includes taxes & fees 8.2/10 Very Good! (4,394 reviews) [](https://expedia.ca/Oakland-Hotels-DoubleTree-By-Hilton-Hotel-Berkeley-Marina.h23800.Hotel-Information) ![Grand Hyatt at SFO](https://images.trvl-media.com/lodging/34000000/33470000/33462100/33462010/e6f59e08_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Grand Hyatt at SFO 55 S McDonnell Rd San Francisco CA CA $397 CA $443 total Apr 5 - Apr 6 includes taxes & fees 9.8/10 Exceptional! (1,532 reviews) [](https://expedia.ca/San-Francisco-Hotels-Grand-Hyatt-At-SFO.h33462010.Hotel-Information) Still don't see what you're looking for? [See all properties in Mission District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F03%2F2026&endDate=24%2F03%2F2026®ionId=134035&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F03%2F2026&endDate=24%2F03%2F2026®ionId=134035&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F03%2F2026&endDate=24%2F03%2F2026®ionId=134035&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F03%2F2026&endDate=24%2F03%2F2026®ionId=134035&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F03%2F2026&endDate=24%2F03%2F2026®ionId=134035&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F03%2F2026&endDate=24%2F03%2F2026®ionId=134035&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Mission District Hotel Reviews ## Find out more about Mission District ## Five Star Hotels in Mission District There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Mission District so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Mission District and get ready to be pampered like never before. #### Get a Great Deal on 5-Star Hotels in Mission District Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places. Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town. #### Make Your Escape to Mission District The results are in, and Mission District 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Mission District! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Mission District today and settle down in the lap of luxury tomorrow. ## Frequently asked questions ### What are the best 5-star hotels in Mission District? ### How much does it cost to stay in a 5-star hotel in Mission District? > - Search for the lowest price per night from CA $188 ### What makes a hotel 5 stars in Mission District? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [Aparthotels in 16th Street Mission Station ](https://www.expedia.ca/16th-Street-Mission-Station-Apart-Hotels.d6176452-aaApartHotels.Travel-Guide-Accommodation) - [Hotels near 16th Street Mission Station ](https://www.expedia.ca/16th-Street-Mission-Station-Hotels.d6176452.Travel-Guide-Hotels) - [Villas in 16th Street Mission Station ](https://www.expedia.ca/16th-Street-Mission-Station-Villas.d6176452-aaVillas.Travel-Guide-Accommodation) - [1 Star Hotels in Paradise Valley ](https://www.expedia.ca/1Star-Paradise-Valley-San-Francisco-Hotels.s10-n553248635976473811-0.Travel-Guide-Filter-Hotels) - 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