Title: 5 Stars Hotels in Mission District, San Francisco from CA $161 - Find Cheap Mission District Hotels With 5 Stars | Expedia.ca [Mission District Travel Guide](https://expedia.ca/San-Francisco-Mission-District.dx134035)[Vacation Rentals in San Francisco](https://expedia.ca/San-Francisco-Vacation-Rentals.d178305.Travel-Guide-VacationRentals)[Flights to San Francisco](https://expedia.ca/Cheap-Flights-To-San-Francisco.d178305.Travel-Guide-Flights)[Things to do in San Francisco](https://expedia.ca/Things-To-Do-In-San-Francisco.d178305.Travel-Guide-Activities)[Mission District Car Rentals](https://expedia.ca/Car-Rentals-In-Mission-District.d134035.Car-Rental-Guide)[Mission District Vacations](https://expedia.ca/Mission-District.d134035.Destination-Travel-Guides) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476332-Mission-District-Sf.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Mission District, San Francisco from CA $161 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mission District 5 Star Hotels Tonight [Nov 7 - Nov 8](https://www.expedia.ca/Hotel-Search?regionId=134035&startDate=2025-11-07&endDate=2025-11-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 8 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=134035&startDate=2025-11-08&endDate=2025-11-09&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=134035&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=134035&startDate=2025-11-14&endDate=2025-11-16&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mission District 5 Star Hotels ![3 outdoor pools, open 6:00 AM to 9:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/6700/6609/d997dca7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![47-inch flat-screen TV with digital channels, Smart TV, table tennis](https://images.trvl-media.com/lodging/1000000/10000/6700/6609/fb1bec56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/6700/6609/ba76b95f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Bay View, Tower](https://images.trvl-media.com/lodging/1000000/10000/6700/6609/3adb309a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Claremont Resort & Club Claremont Hills 8.8/10 Excellent (1002) "Clean room, great staff, wonderful property" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $392 CA $536 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Oakland-Hotels-Claremont-Club-Spa-A-Fairmont-Hotel.h6609.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/6f6889e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/94a155f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/94d8cb6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/48a8da0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairmont San Francisco Downtown San Francisco 9.0/10 Wonderful (1404) "Great room and staff" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Benjamin CA $324 CA $439 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information) ![City view](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/d044cc49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/111bcf12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/d5b628f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Union Square Deluxe King Bed](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/b4524bad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Taj Campton Place Union Square 9.2/10 Wonderful (1001) "I would stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $239 CA $329 total includes taxes & fees Nov 27 - Nov 28 [](https://www.expedia.ca/San-Francisco-Hotels-Taj-Campton-Place.h23383.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/w4000h2663x0y0-df4f3756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/5653c9b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/952f2e20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, cocktail bar](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/09d35b14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palace Hotel, a Luxury Collection Hotel, San Francisco Downtown San Francisco 9.2/10 Wonderful (1002) "overall great property" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $392 CA $462 total includes taxes & fees Nov 27 - Nov 28 [](https://www.expedia.ca/San-Francisco-Hotels-Palace-Hotel.h27274.Hotel-Information) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/30000/22200/22148/5b42d596.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view from property](https://images.trvl-media.com/lodging/1000000/30000/22200/22148/4f41225f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Frette Italian sheets, premium bedding, pillowtop beds](https://images.trvl-media.com/lodging/1000000/30000/22200/22148/9c478019.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/30000/22200/22148/dadccd3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, San Francisco Downtown San Francisco 9.4/10 Exceptional (1001) "Great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley CA $422 CA $565 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/San-Francisco-Hotels-The-Ritz-Carlton.h22148.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/bff475ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves breakfast, lunch, and dinner](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/c14db855.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; local and international cuisine ](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/4df53291.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/ab6ff173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel San Francisco Downtown San Francisco 9.4/10 Exceptional (1015) "great room and staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) chunguang CA $585 CA $689 total includes taxes & fees Nov 14 - Nov 15 [](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information) ![Breakfast, lunch, dinner served; alfresco dining](https://images.trvl-media.com/lodging/2000000/1140000/1138300/1138217/60488ea7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1140000/1138300/1138217/24d494d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace Studio Suite | Terrace/patio](https://images.trvl-media.com/lodging/2000000/1140000/1138300/1138217/0d31bb88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/2000000/1140000/1138300/1138217/2ac83be8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 1 Hotel San Francisco Downtown San Francisco 9.2/10 Wonderful (466) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Helen CA $464 CA $626 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/San-Francisco-Hotels-1-Hotel-San-Francisco.h1138217.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/41a2cb6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/54bc54cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/91a3ba7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/ac69c36b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel San Francisco at Embarcadero Downtown San Francisco 9.6/10 Exceptional (1002) "Rooms great location, friendly and hospitable staff. Great experience overall!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mac santa CA $593 CA $698 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco-At-Embarcadero.h6505.Hotel-Information) ![Suite, 1 Bedroom, Non Smoking, Corner](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/29f2f698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/w4000h2662x0y0-fc84c036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves lunch and dinner](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/6f2f905e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 Bedroom](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/9c4e94de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The St. Regis San Francisco Downtown San Francisco 9.4/10 Exceptional (688) "Fantastic room and service" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wei Him CA $571 CA $737 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/80000/74200/74183/35b03efd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/1000000/80000/74200/74183/50bb3f17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City View Guestroom | City view](https://images.trvl-media.com/lodging/1000000/80000/74200/74183/caeeeb03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/80000/74200/74183/03045211.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Drisco Pacific Heights 9.8/10 Exceptional (451) "The breakfast was amazing, lots of variety including hot items cooked freshly" ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Julie Ann CA $837 CA $973 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Drisco.h74183.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1860000/1853300/1853240/9ae8226d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1860000/1853300/1853240/6f41305b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1860000/1853300/1853240/9a41a095.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1860000/1853300/1853240/3fbb1d83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairmont Heritage Place, Ghirardelli Square Fisherman's Wharf 9.4/10 Exceptional (384) "Loved our stay here. Location was perfect for our trip, close to the Wharf. The staff is amazing and accommodated every request. We will definitely return!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth CA $1,240 CA $1,457 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/San-Francisco-Hotels-Fairmont-Heritage-Place.h1853240.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/8000000/7070000/7064400/7064385/193b84d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/8000000/7070000/7064400/7064385/ef9e1389.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/8000000/7070000/7064400/7064385/3ae08081.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/8000000/7070000/7064400/7064385/fb8da040.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Neighbourgood Sutter Mansion Western Addition 9.4/10 Exceptional (224) "Beautifully restored property with very tasteful furnishings. Staff very helpful and polite. A real pleasure to stay in. Top quality stay." ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Jonathan CA $403 CA $469 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/San-Francisco-Hotels-Mansion-On-Sutter.h7064385.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90330000/90324300/90324275/w4327h2866x6y3-9b9c25a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/91000000/90330000/90324300/90324275/6e060fa7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![60-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/91000000/90330000/90324300/90324275/w2869h1911x5y6-aba49a45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/91000000/90330000/90324300/90324275/9a697550.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dimond Abode Vacation Rental 3428 Dimond 9.4/10 Exceptional (6) "My son and I stayed here because it was close to Northeastern University. I didn’t know what to expect. I will stay here anytime I plan a visit back. They were so kind to get us in an hour early when I called very last minute. The place is beautiful, spotless and roomy. I felt safe also. Even walked to dinner just a couple blocks away. My son had forgotten his toothbrush, but no worries, they had a tooth pack in the bathroom for him to use. They also provided soaps, mouthwash, lotion and plenty... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Davia [](https://www.expedia.ca/Oakland-Hotels-Dimond-Abode-3428.h90324275.Hotel-Information) ![Deluxe House | Balcony](https://images.trvl-media.com/lodging/112000000/111470000/111467100/111467039/f0f8fb7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111470000/111467100/111467039/19449633_edited_3b58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe House | Living room](https://images.trvl-media.com/lodging/112000000/111470000/111467100/111467039/8267bbc3_edited_53c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe House](https://images.trvl-media.com/lodging/112000000/111470000/111467100/111467039/9ec933cb_edited_b2a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dimond Abode Vacation Rental Dimond 10/10 Exceptional (1) "The unit was extremely clean and having access to a garage was definitely a plus for our stay! Nice touches, especially coffee / tea , snacks, and a well equipped kitchen made us feel welcomed the minute we stepped through the door. A+" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Camille [](https://www.expedia.ca/Oakland-Hotels-Dimond-Abode-Vacation-Rental.h111467039.Hotel-Information) ![Studio (4 Bedrooms) | Living area](https://images.trvl-media.com/lodging/120000000/119570000/119566100/119566030/w1919h1276x1y1-422cf340.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio (4 Bedrooms) | Front of property](https://images.trvl-media.com/lodging/120000000/119570000/119566100/119566030/w1919h1276x1y1-7d592718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio (4 Bedrooms)](https://images.trvl-media.com/lodging/120000000/119570000/119566100/119566030/w1919h1276x1y1-4ca2fc07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio (4 Bedrooms) | Living area](https://images.trvl-media.com/lodging/120000000/119570000/119566100/119566030/w1919h1276x1y1-80f73dd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### KBM Resorts Long Term Lease 4 Bed/3 Bath Luxury Home Pool, Bbq, Fitness Center Orinda Retreat Ldd-32 Orinda [](https://www.expedia.ca/Orinda-Hotels-KBM-Resorts-Long-Term-Lease-4-Bed3-Bath-Luxury-Home-Pool.h119566030.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mission-District-San-Francisco-Hotels.s50-n134035-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mission-District-San-Francisco-Hotels.s50-n134035-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mission District. ![Hyatt Regency San Francisco](https://images.trvl-media.com/lodging/1000000/30000/23800/23774/1f7903cc_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hyatt Regency San Francisco 5 Embarcadero Center, San Francisco, CA CA $252 CA $362 total Nov 9 - Nov 10 includes taxes & fees 9.2/10 Wonderful! (1,957 reviews) [](https://expedia.ca/San-Francisco-Hotels-Hyatt-Regency-San-Francisco.h23774.Hotel-Information) ![Hilton San Francisco Financial District](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/77af977e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hilton San Francisco Financial District 750 Kearny St, San Francisco, CA CA $137 CA $161 total Nov 30 - Dec 1 includes taxes & fees 8.6/10 Excellent! (1,969 reviews) [](https://expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information) ![Hotel Riu Plaza Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Riu Plaza Fisherman's Wharf 2500 Mason St, San Francisco, CA CA $154 CA $239 total Nov 30 - Dec 1 includes taxes & fees 8.8/10 Excellent! (7,029 reviews) [](https://expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information) Still don't see what you're looking for? [See all properties in Mission District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F11%2F2025&endDate=09%2F11%2F2025®ionId=134035&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F11%2F2025&endDate=09%2F11%2F2025®ionId=134035&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F11%2F2025&endDate=09%2F11%2F2025®ionId=134035&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F11%2F2025&endDate=09%2F11%2F2025®ionId=134035&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F11%2F2025&endDate=09%2F11%2F2025®ionId=134035&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F11%2F2025&endDate=09%2F11%2F2025®ionId=134035&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Mission District Hotel Reviews ![Fairmont San Francisco](//images.trvl-media.com/lodging/1000000/20000/18200/18200/6f6889e4_y.jpg) ### Fairmont San Francisco 10/10 Excellent "A lovely hotel. " [](https://expedia.ca/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information) ## Find out more about Mission District ## Five Star Hotels in Mission District There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Mission District so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Mission District and get ready to be pampered like never before. #### Get a Great Deal on 5-Star Hotels in Mission District Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places. Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town. #### Make Your Escape to Mission District The results are in, and Mission District 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Mission District! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Mission District today and settle down in the lap of luxury tomorrow. ## Frequently asked questions ### What are the best 5-star hotels in Mission District? > Based on reviews by Expedia travellers, [Mansion on Sutter](https://www.expedia.ca/San-Francisco-Hotels-Mansion-On-Sutter.h7064385.Hotel-Information) is one of the top-rated properties for a luxurious escape in the San Francisco neighbourhood of Mission District. Looking for more 5-star hotels around the area? [Four Seasons Hotel San Francisco](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information) and [The St. Regis San Francisco](https://www.expedia.ca/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information) will cater to your upscale desires. ### How much does it cost to stay in a 5-star hotel in Mission District? > The amount you pay for a 5-star hotel in Mission District can vary based on the time of year you travel and how long you plan to be away, among other factors. Use our price per night filter and other search tools to land the best deal on a high-end stay. > > > > - Search for the lowest price per night from CA $161 ### What makes a hotel 5 stars in Mission District? > Faultless guest service is the foundation of every 5-star hotel in Mission District. From the moment you enter the lobby, staff attend to your every need, whether answering room service calls 24/7 or providing in-room massages. Additionally, hotels must offer upscale conveniences to be eligible for a 5-star rating. 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