Title: 5 Stars Hotels in Medical Center District, San Antonio from CA $145 - Find Cheap Medical Center District Hotels With 5 Stars | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![River walk in San Antonio](https://images.trvl-media.com/place/553248635978913844/ef5a7faf-f6d9-4f7e-b325-ac477c5ad14d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Medical Center District, San Antonio from CA $145 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical Center District 5 Star Hotels Tonight [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-12&endDate=2025-12-13&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-13&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Medical Center District 5-star hotels ![Outdoor pool, open 7:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/60000000/59770000/59768200/59768128/w2785h3840x3y0-5b12fdb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters, minibar](https://images.trvl-media.com/lodging/60000000/59770000/59768200/59768128/w3837h2568x3y3-37faca17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar](https://images.trvl-media.com/lodging/60000000/59770000/59768200/59768128/w3837h2555x3y5-c9ef89f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed (Studio Suite with 1 King Bed)](https://images.trvl-media.com/lodging/60000000/59770000/59768200/59768128/ea5838bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Thompson San Antonio - Riverwalk, by Hyatt [](https://www.expedia.ca/San-Antonio-Hotels-Thompson-San-Antonio.h59768128.Hotel-Information) Downtown San Antonio 9.0/10 Wonderful (913) "Outstanding hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hicham CA $233 CA $322 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/San-Antonio-Hotels-Thompson-San-Antonio.h59768128.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/45000000/44920000/44917700/44917616/f317cc37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Suite, 2 Bedrooms, Non Smoking, Pool Access | Living area](https://images.trvl-media.com/lodging/45000000/44920000/44917700/44917616/b7c865e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio | In-room dining](https://images.trvl-media.com/lodging/45000000/44920000/44917700/44917616/b572e6e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/45000000/44920000/44917700/44917616/d35f7d54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Luxury Suites at Arrive Eilan [](https://www.expedia.ca/San-Antonio-Hotels-The-Luxury-La-Cantera-Suites.h44917616.Hotel-Information) La Cantera District 7.4/10 Good (129) "Stayed at this location while visiting our daughter. Massive investment and very clean, although a little bland in its commissioning!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maurice [](https://www.expedia.ca/San-Antonio-Hotels-The-Luxury-La-Cantera-Suites.h44917616.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Medical-Center-District-San-Antonio-Hotels.s50-n553248635978913844-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Medical-Center-District-San-Antonio-Hotels.s50-n553248635978913844-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Medical Center District. ![Hotel Valencia Riverwalk](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Valencia Riverwalk 150 E Houston St San Antonio TX CA $132 CA $195 total Dec 15 - Dec 16 includes taxes & fees 9.4/10 Exceptional! (2,228 reviews) [](https://expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information) ![Riverwalk Plaza](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Riverwalk Plaza 100 Villita Street San Antonio TX CA $123 CA $145 total Dec 14 - Dec 15 includes taxes & fees 8/10 Very Good! (6,161 reviews) [](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![The Westin Riverwalk, San Antonio](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Westin Riverwalk, San Antonio 420 W Market St San Antonio TX CA $214 CA $255 total Dec 22 - Dec 23 includes taxes & fees 8.8/10 Excellent! (1,429 reviews) [](https://expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information) Still don't see what you're looking for? [See all properties in Medical Center District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Medical Center District Hotel Reviews ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Medical Centre District? > - Search for the lowest price per night from CA $145 ### What makes a hotel 5 stars in Medical Centre District? ### Are there any 5-star all-inclusive resorts in Medical Centre District? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [1 Star Hotels in Fredericksburg ](https://www.expedia.ca/1Star-Fredericksburg-Hotels.s10-0-d6059096.Travel-Guide-Filter-Hotels) - [1 Star Hotels in Southside ](https://www.expedia.ca/1Star-Southside-Hotels.s10-0-d553248635939576783.Travel-Guide-Filter-Hotels) - [2 Star Hotels in North San Antonio - SAT ](https://www.expedia.ca/2Star-North-San-Antonio-SAT-Hotels.s20-0-d553248633938962547.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Southside ](https://www.expedia.ca/2Star-Southside-Hotels.s20-0-d553248635939576783.Travel-Guide-Filter-Hotels) - 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