Title: 5 Stars Hotels in Medical Center Area, Boston - Find Cheap Medical Center Area Hotels With 5 Stars | Expedia.ca [Medical Center Area Travel Guide](https://expedia.ca/Boston-Medical-Center-Area.dx553248635976482082)[Vacation Rentals in Boston](https://expedia.ca/Boston-Vacation-Rentals.d178239.Travel-Guide-VacationRentals)[Flights to Boston](https://expedia.ca/Cheap-Flights-To-Boston.d178239.Travel-Guide-Flights)[Things to do in Boston](https://expedia.ca/Things-To-Do-In-Boston.d178239.Travel-Guide-Activities)[Medical Center Area Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-Area.d553248635976482082.Car-Rental-Guide)[Medical Center Area Vacations](https://expedia.ca/Medical-Center-Area.d553248635976482082.Destination-Travel-Guides) ![Isabella Stewart Gardner Museum featuring a city, night scenes and modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/21000/21171-Isabella-Stewart-Gardner-Museum.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Medical Center Area, Boston ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical Center Area 5 Star Hotels Tonight [Oct 28 - Oct 29](https://www.expedia.ca/Hotel-Search?regionId=553248635976482082&startDate=2025-10-28&endDate=2025-10-29&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 29 - Oct 30](https://www.expedia.ca/Hotel-Search?regionId=553248635976482082&startDate=2025-10-29&endDate=2025-10-30&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976482082&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635976482082&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical Center Area 5 Star Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Medical-Center-Area-Boston-Hotels.s50-n553248635976482082-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Medical-Center-Area-Boston-Hotels.s50-n553248635976482082-0.Travel-Guide-Filter-Hotels) ## Top Medical Center Area Hotel Reviews ## Explore a world of travel with Expedia - 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[Dana-Farber Cancer Institute](https://www.expedia.ca/Dana-Farber-Cancer-Institute-FenwayKenmore.d6070063.Vacation-Attraction) - [Fenway Park](https://www.expedia.ca/Fenway-Park-FenwayKenmore.d6023384.Vacation-Attraction) - [Isabella Stewart Gardner Museum](https://www.expedia.ca/Isabella-Stewart-Gardner-Museum-FenwayKenmore.d6070085.Vacation-Attraction) - [Car rentals near Fenway Park](https://www.expedia.ca/Car-Rentals-In-Fenway-Park.d6023384.Car-Rental-Guide) - [Car rentals near Isabella Stewart Gardner Museum](https://www.expedia.ca/Car-Rentals-In-Isabella-Stewart-Gardner-Museum.d6070085.Car-Rental-Guide) - [Mini Car Rentals near Isabella Stewart Gardner Museum](https://www.expedia.ca/Mini-Car-Rentals-In-Isabella-Stewart-Gardner-Museum.d6070085-tMini.Car-Rental-Guide-Class) - [Premium Car Rentals near Fenway Park](https://www.expedia.ca/Premium-Car-Rentals-In-Fenway-Park.d6023384-tPremium.Car-Rental-Guide-Class) - [Things to do in Boston](https://www.expedia.ca/Things-To-Do-In-Boston.d178239.Travel-Guide-Activities) - 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