Title: 5 Stars Hotels in Mayo River, Virginia from CA $610 - Find Cheap Mayo River Hotels With 5 Stars | Expedia.ca [Mayo River Travel Guide](https://expedia.ca/Mayo-River.dx553248635976006279)[Hotels in Mayo River](https://expedia.ca/Mayo-River-Hotels.d553248635976006279.Travel-Guide-Hotels)[Vacation Rentals in Mayo River](https://expedia.ca/Mayo-River-Vacation-Rentals.d553248635976006279.Travel-Guide-VacationRentals)[Flights to Mayo River](https://expedia.ca/Cheap-Flights-To-Mayo-River.d553248635976006279.Travel-Guide-Flights)[Mayo River Car Rentals](https://expedia.ca/Car-Rentals-In-Mayo-River.d553248635976006279.Car-Rental-Guide)[Mayo River Vacation Packages](https://expedia.ca/Mayo-River.d553248635976006279.Destination-Travel-Guides) ![The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.](https://images.trvl-media.com/place/553248621561864249/54558157-d5bc-4ba5-a77d-f9a917492c5a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ed Mayfield # 5 Stars Hotels in Mayo River, Virginia from CA $610 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mayo River 5 Star Hotels Tonight [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=553248635976006279&startDate=2025-12-12&endDate=2025-12-13&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635976006279&startDate=2025-12-13&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635976006279&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635976006279&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mayo River 5-star hotels ![Exterior](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/d7ce6da6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/84ebd106.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Tree House, 1 King Bed (Barn Owl, Adults Only)](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/ef77317a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds (Fairway)](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/347c008f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lodge at Primland, Auberge Collection [](https://www.expedia.ca/Meadows-Of-Dan-Hotels-The-Lodge-At-Primland.h3633184.Hotel-Information) Meadows Of Dan 9.0/10 Wonderful (25) "The resort is an experience. The staff were helpful and genuine. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melinda CA $486 CA $610 total includes taxes & fees Jan 8 - Jan 9, 2026 [](https://www.expedia.ca/Meadows-Of-Dan-Hotels-The-Lodge-At-Primland.h3633184.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mayo-River-Hotels.s50-0-d553248635976006279.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mayo-River-Hotels.s50-0-d553248635976006279.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mayo River. ![Tuggle's Gap Roadside Inn - Blue Ridge Parkway](https://images.trvl-media.com/lodging/90000000/89180000/89174900/89174849/f1861bf5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Tuggle's Gap Roadside Inn - Blue Ridge Parkway 3351 Parkway Ln S Floyd VA [Get rates](https://expedia.ca/Hotel-Search?startDate=26%2F12%2F2025&endDate=27%2F12%2F2025&selected=89174849&PinnedHotelID=89174849&HadPinnedHotel=true®ionId=553248635976006279) 9.2/10 Wonderful! (157 reviews) [](https://expedia.ca/Floyd-Hotels-Tuggles-Gap-Roadside-Inn.h89174849.Hotel-Information) Still don't see what you're looking for? [See all properties in Mayo River.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025®ionId=553248635976006279&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025®ionId=553248635976006279&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025®ionId=553248635976006279&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025®ionId=553248635976006279&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025®ionId=553248635976006279&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025®ionId=553248635976006279&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Mayo River Head to sights like Reynolds Homestead as you discover the local area in Mayo River. [See all hotels in Mayo River](https://www.expedia.ca/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27&adults=2®ionId=553248635976006279) ![The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.](https://images.trvl-media.com/place/553248621561864249/54558157-d5bc-4ba5-a77d-f9a917492c5a.jpg?impolicy=fcrop&w=899&h=675&p=1&q=high) Photo by Ed Mayfield ## Top Mayo River Hotel Reviews ![The Lodge at Primland, Auberge Collection](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/d7ce6da6_y.jpg) ### The Lodge at Primland, Auberge Collection 10/10 Excellent "The resort is an experience. The staff were helpful and genuine. " [](https://expedia.ca/Meadows-Of-Dan-Hotels-The-Lodge-At-Primland.h3633184.Hotel-Information) ## Find out more about Mayo River Luxury is the name of the game at the best 5 Stars hotels in Mayo River. If you want to vacation like a true VIP, these are the places to go; from spacious resorts to boutique-inspired hot spots, the top Mayo River 5 Stars hotels are dedicated to immersing you in the ultimate experience. Want to relax with a serene treatment at a designer spa? These properties offer them. Interested in tasting delicious dishes from top chefs? The gourmet restaurants at the 5 Stars Mayo River hotels have you covered. You’ll even find first-class hotels near the city’s must-see attractions and most upscale entertainment districts. Plus, when you book your trip with Expedia.ca, you’ll get access to fantastic rates and seasonal discounts, so you can take advantage of a cheap deal on 5 Stars hotels Mayo River without giving up even an inch of quality. Everything your heart desires (and a few perks designed to make it skip a beat): That’s what’s on offer when you plan a trip to the hotels with 5 Stars in Mayo River. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [1 Star Hotels in Hillsville ](https://www.expedia.ca/1Star-Hillsville-Hotels.s10-0-d6056937.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Axton ](https://www.expedia.ca/2Star-Axton-Hotels.s20-0-d6351116.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Azen ](https://www.expedia.ca/2Star-Azen-Hotels.s20-0-d553248635975865353.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Moneta ](https://www.expedia.ca/3Star-Moneta-Hotels.s30-0-d6348084.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Rustburg ](https://www.expedia.ca/3Star-Rustburg-Hotels.s30-0-d3000460651.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Walkers Creek ](https://www.expedia.ca/3Star-Walkers-Creek-Hotels.s30-0-d553248635976006656.Travel-Guide-Filter-Hotels) - 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