Title: 4 Stars Hotels in South Main, Houston from CA $148 - Find Cheap South Main Hotels With 4 Stars | Expedia.ca [South Main Travel Guide](https://expedia.ca/Houston-South-Main.dx553248635976386992)[Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[South Main Car Rentals](https://expedia.ca/Car-Rentals-In-South-Main.d553248635976386992.Car-Rental-Guide)[South Main Vacations](https://expedia.ca/South-Main.d553248635976386992.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/7fff8623dc31b090fdc6a6747a27a07c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Hazem Abdul # 4 Stars Hotels in South Main, Houston from CA $148 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Main 4 Star Hotels Tonight [Nov 3 - Nov 4](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-11-03&endDate=2025-11-04&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-11-04&endDate=2025-11-05&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-11-14&endDate=2025-11-16&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Main 4 Star Hotels ![Exterior detail](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/ec3f4d74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/109ddc6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, down comforters, in-room safe, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/d7c28c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria Greater Uptown 8.2/10 Very good (2818) "Nice stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Corey CA $145 CA $171 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/76e7278c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/c91eaea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/c1fa2b90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Club Quarters Hotel Downtown, Houston Downtown Houston 8.4/10 Very good (3875) "Stay was great, check in was very easy and it was in a great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristianna CA $128 CA $149 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![1 bedroom, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/47c5ade4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hydromassage showerhead, designer toiletries, hair dryer, bathrobes](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/4c4b17d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/5a45a026.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/0f950f88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Zaza Houston Museum District South Central Houston 9.0/10 Wonderful (1809) "Great location, wonderful staff, and always down to accommodate" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara CA $268 CA $371 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Houston-Hotels-Hotel-Zaza-Houston-Museum-District.h3306.Hotel-Information) ![Sundeck](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/294f3d50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/12af8c32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/f8ddb5e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/f2e085ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Houston Plaza/Medical Center Texas Medical Center 8.4/10 Very good (1649) "Bedding is so comfortable and it's awesome to have a coffee house in the lobby" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $130 CA $153 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Houston-Hotels-Hilton-Houston-Plaza-Medical-Center.h25188.Hotel-Information) ![Business centre](https://images.trvl-media.com/lodging/1000000/30000/20200/20177/682ca680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/30000/20200/20177/6607885f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/20200/20177/206df77c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/20200/20177/0abe48de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel Houston - Greenway Plaza Greenway Plaza-Upper Kirby 8.2/10 Very good (1289) "Amazing front desk staff and met our needs! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert CA $127 CA $148 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Houston-Greenway-Plaza.h20177.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/0b2adb37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/024118ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/d9c7e5d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/8cd55d48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Magnolia Hotel Houston, A Tribute Portfolio Hotel Downtown Houston 9.2/10 Wonderful (1246) "Hotel was great and well maintained with friendly staff. Unfortunately the area around it is not so safe at night but that’s just Houston downtown in general." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fernando CA $175 CA $206 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Houston-Hotels-Magnolia-Hotel-Houston.h907459.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/79071c33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/516b3f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/1b15f0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Houston Hotel Greater Uptown 9.0/10 Wonderful (1005) "Really enjoyed my stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) kenneth CA $234 CA $278 total includes taxes & fees Nov 21 - Nov 22 [](https://www.expedia.ca/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) ![Lunch, dinner, brunch served; Italian cuisine ](https://images.trvl-media.com/lodging/1000000/30000/25000/24968/dbf192ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/30000/25000/24968/5fe84d16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25000/24968/6ad32aff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/1000000/30000/25000/24968/8d7abbc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### C. Baldwin, Curio Collection by Hilton Downtown Houston 8.4/10 Very good (1004) "I always enjoy staying at the C. Baldwin. Hotel is clean and modern." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) George CA $202 CA $274 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/Houston-Hotels-C-Baldwin.h24968.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/dc9d050c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/a72ac5b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![50-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/w3836h2556x4y4-af1501b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/w3837h2505x3y0-1cfabad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Blossom Hotel Houston, Curio Collection by Hilton Texas Medical Center 9.0/10 Wonderful (3606) "Clean friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alfreida CA $194 CA $227 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Houston-Hotels-Blossom-Hotel-Houston.h58985846.Hotel-Information) ![City view from property](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/f3f90eac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/e16d70bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/0c8e0486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Whitehall Houston Downtown Houston 8.6/10 Excellent (1851) "Great staff nice rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew CA $178 CA $208 total includes taxes & fees Nov 21 - Nov 22 [](https://www.expedia.ca/Houston-Hotels-The-Whitehall-Houston.h693655.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, City View | View from room](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/a6761ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, pillowtop beds](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/w3836h2556x4y4-d736e03c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/b032cc4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Royal Sonesta Houston Galleria The Galleria 8.4/10 Very good (1347) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $167 CA $195 total includes taxes & fees Nov 21 - Nov 22 [](https://www.expedia.ca/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) ![Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/9a708987.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/e4ab6d84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/55e246fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/b1e04b0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Houston/Galleria The Galleria 9.0/10 Wonderful (1122) "Wonderful property!!! Very much enjoyed our stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew CA $189 CA $223 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Houston-Hotels-Hyatt-Regency-HoustonGalleria.h10620692.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/09dd0b59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/8cd20a4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, rooftop bar](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/51d97881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/79245093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Americas-Houston Downtown Houston 9.4/10 Exceptional (1564) "Excellent location and great customer service." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ana CA $194 CA $230 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Houston-Hotels-Hilton-Americas-Houston.h976144.Hotel-Information) ![Cocktail bar](https://images.trvl-media.com/lodging/19000000/18470000/18465900/18465864/414eab2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18470000/18465900/18465864/8a8e9bfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/19000000/18470000/18465900/18465864/04fe0eec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/19000000/18470000/18465900/18465864/dedc2cf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Le Meridien Houston Downtown Downtown Houston 8.8/10 Excellent (1010) "Friendliest staff, clean room. Hotel was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeannie CA $178 CA $208 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Houston-Hotels-Le-Meridien-Houston-Downtown.h18465864.Hotel-Information) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/20000/11200/11117/b45a8086.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/11200/11117/7e53cf9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/11200/11117/9fc9fc31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/11200/11117/586ba511.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Galleria Houston The Galleria 9.0/10 Wonderful (1004) "Greatly located in the Houston Galleria Mall. The staff is kind and responsive. Food is good for room service." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alfredo Javier CA $223 CA $304 total includes taxes & fees Nov 28 - Nov 29 [](https://www.expedia.ca/Houston-Hotels-The-Westin-Galleria-Houston.h11117.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/94000000/93260000/93258000/93257980/c91d9e37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/94000000/93260000/93258000/93257980/0b83377a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/94000000/93260000/93258000/93257980/76bb005d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Panoramic)](https://images.trvl-media.com/lodging/94000000/93260000/93258000/93257980/w3837h2556x3y3-2afa72c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Thompson Houston, by Hyatt Fourth Ward 9.4/10 Exceptional (213) "The staff members are so professional and courteous. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daintee CA $345 CA $463 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Houston-Hotels-Thompson-Houston.h93257980.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/e3524014.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar, garden views, open daily](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/w6106h4075x5y0-36a0348c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/524bd131.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/1f1ee4a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Moran CITYCENTRE Memorial 9.0/10 Wonderful (1006) "i absolutely enjoyed my stay. will definitely be back." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley CA $192 CA $265 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Houston-Hotels-The-Moran-CITYCENTRE.h2302841.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/24000000/23840000/23830900/23830866/e83f776d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/24000000/23840000/23830900/23830866/5f5e8d93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/24000000/23840000/23830900/23830866/29e4bd94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, in-room safe, individually furnished](https://images.trvl-media.com/lodging/24000000/23840000/23830900/23830866/b72d00fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### InterContinental Houston by IHG Texas Medical Center 9.2/10 Wonderful (1005) "Very well maintenance property, beautiful lobby and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Viji CA $195 CA $256 total includes taxes & fees Nov 28 - Nov 29 [](https://www.expedia.ca/Houston-Hotels-InterContinental-Houston-Medical-Center.h23830866.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16200/16154/5cc6610b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/16200/16154/75d213df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/1000000/20000/16200/16154/a3baec81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Mini-fridge, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/20000/16200/16154/c3718846.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Houston Marriott Medical Center/Museum District Texas Medical Center 9.0/10 Wonderful (1001) "Peaceful and relaxing stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brad CA $200 CA $277 total includes taxes & fees Nov 28 - Nov 29 [](https://www.expedia.ca/Houston-Hotels-Houston-Marriott-Medical-CenterMuseum-District.h16154.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17500/17456/f84799ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom | Living room](https://images.trvl-media.com/lodging/1000000/20000/17500/17456/8727d51c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/17500/17456/737203be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/17500/17456/343cba22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Houston Marriott Westchase Westchase 8.2/10 Very good (1005) "Enjoyed our stay at this location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roger CA $151 CA $178 total includes taxes & fees Nov 21 - Nov 22 [](https://www.expedia.ca/Houston-Hotels-Houston-Marriott-Westchase.h17456.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-South-Main-Houston-Hotels.s40-n553248635976386992-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-South-Main-Houston-Hotels.s40-n553248635976386992-0.Travel-Guide-Filter-Hotels) ## Explore similar 5-star hotels Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in South Main. ![The Post Oak Hotel at Uptown Houston](https://images.trvl-media.com/lodging/23000000/22350000/22340300/22340244/d55af368_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Post Oak Hotel at Uptown Houston 1600 West Loop South, Houston, TX CA $701 CA $821 total Nov 17 - Nov 18 includes taxes & fees 9.6/10 Exceptional! (849 reviews) [](https://expedia.ca/Houston-Hotels-The-Post-Oak-Hotel-At-Uptown-Houston.h22340244.Hotel-Information) ![Four Seasons Hotel Houston](https://images.trvl-media.com/lodging/1000000/30000/20200/20193/bf3873ac_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Four Seasons Hotel Houston 1300 Lamar St, Houston, TX CA $813 CA $958 total Nov 21 - Nov 22 includes taxes & fees 9/10 Wonderful! (1,001 reviews) [](https://expedia.ca/Houston-Hotels-Four-Seasons-Hotel-Houston.h20193.Hotel-Information) ![JW Marriott Houston Downtown](https://images.trvl-media.com/lodging/8000000/7310000/7301300/7301257/75cdec53_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### JW Marriott Houston Downtown 806 Main Street, Houston, TX CA $257 CA $310 total Nov 28 - Nov 29 includes taxes & fees 8.8/10 Excellent! (1,012 reviews) [](https://expedia.ca/Houston-Hotels-JW-Marriott-Houston-Downtown.h7301257.Hotel-Information) Still don't see what you're looking for? [See all properties in South Main.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635976386992&star=40) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635976386992&star=40&star=40&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635976386992&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635976386992&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635976386992&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635976386992&star=40&star=40&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top South Main Hotel Reviews ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](//images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce_y.jpg) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 10/10 Excellent "Everything is good " [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information) ![Magnolia Hotel Houston, A Tribute Portfolio Hotel](//images.trvl-media.com/lodging/1000000/910000/907500/907459/0b2adb37_y.jpg) ### Magnolia Hotel Houston, A Tribute Portfolio Hotel 10/10 Excellent "Great rooms and courteous staff. Exceeded my expectations." [](https://expedia.ca/Houston-Hotels-Magnolia-Hotel-Houston.h907459.Hotel-Information) ![The Whitehall Houston](//images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056_y.jpg) ### The Whitehall Houston 10/10 Excellent "Front desk staff, Kelvin and Shirley, were very friendly and helpful. The room was comfortable and the shower had excellent water pressure. Close to a lot of good restaurants also." [](https://expedia.ca/Houston-Hotels-The-Whitehall-Houston.h693655.Hotel-Information) ![DoubleTree by Hilton Hotel Houston - Greenway Plaza](//images.trvl-media.com/lodging/1000000/30000/20200/20177/682ca680_y.jpg) ### DoubleTree by Hilton Hotel Houston - Greenway Plaza 10/10 Excellent "Yes" [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Houston-Greenway-Plaza.h20177.Hotel-Information) ![The Royal Sonesta Houston Galleria](//images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960_y.jpg) ### The Royal Sonesta Houston Galleria 10/10 Excellent "Yes. Everything was perfect! I will stay again" [](https://expedia.ca/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) ![Blossom Hotel Houston, Curio Collection by Hilton](//images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/dc9d050c_y.jpg) ### Blossom Hotel Houston, Curio Collection by Hilton 10/10 Excellent "Always stay here when in the area. " [](https://expedia.ca/Houston-Hotels-Blossom-Hotel-Houston.h58985846.Hotel-Information) ![Club Quarters Hotel Downtown, Houston](//images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg) ### Club Quarters Hotel Downtown, Houston 10/10 Excellent "Everything was great!" [](https://expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![Omni Houston Hotel](//images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4_y.jpg) ### Omni Houston Hotel 10/10 Excellent "Great site. Great people. Good breakfast!! 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[Beach Hotel Hotels in Southwest Houston](https://www.expedia.ca/Southwest-Houston-Hotels-Beach-Hotel.0-0-d6189441-tBeachHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Southwest Houston](https://www.expedia.ca/Southwest-Houston-Hotels-Casino-Hotel.0-0-d6189441-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Southwest Houston Hotels](https://www.expedia.ca/Southwest-Houston-Hotels.d6189441.Travel-Guide-Hotels) - [Aparthotels in Stadium Park/Astrodome Station](https://www.expedia.ca/Stadium-ParkAstrodome-Station-Apart-Hotels.d6211680-aaApartHotels.Travel-Guide-Accommodation) - [Hostels in Stadium Park/Astrodome Station](https://www.expedia.ca/Stadium-ParkAstrodome-Station-Hostels.d6211680-aaHostels.Travel-Guide-Accommodation) - [Hotels near Stadium Park/Astrodome Station](https://www.expedia.ca/Stadium-ParkAstrodome-Station-Hotels.d6211680.Travel-Guide-Hotels) - [Farmstay in TMC Transit Center](https://www.expedia.ca/TMC-Transit-Center-Agritourism.d6211673-aaAgritourism.Travel-Guide-Accommodation) - [Hotels near Texas Children's Hospital](https://www.expedia.ca/Texas-Childrens-Hospital-Hotels.0-l553248635389801905-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Cheap-Hotels.0-n6143504-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Family-Hotel.0-n6143504-0-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Hotel-With-Pool.0-n6143504-0-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Hotels-With-Free-Airport-Shuttle.0-n6143504-0-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Free Breakfast in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Hotels-With-Free-Breakfast.0-n6143504-0-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Hotels-With-Kitchenettes.0-n6143504-0-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Hyatt Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Hyatt-Hotels.0-n6143504-0--bHyattHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Luxury-Hotel.0-n6143504-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Mountain Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Mountain-Hotels.0-n6143504-0-tMountainHotels.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Oceanfront-Hotels.0-n6143504-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Pet-Friendly-Hotel.0-n6143504-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Shopping Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Shopping-Hotel.0-n6143504-0-tShoppingHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Texas Medical Center](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels-Waterpark-Hotels.0-n6143504-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Texas Medical Center Hotels](https://www.expedia.ca/Texas-Medical-Center-Houston-Hotels.0-n6143504-0.Travel-Guide-Filter-Hotels) - [Willow Meadows/Willowbend Area Hotels](https://www.expedia.ca/Willow-MeadowsWillowbend-Area-Houston-Hotels.0-n553248635976384858-0.Travel-Guide-Filter-Hotels) - [Flights to Houston](https://www.expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights) - [Flights from Calgary to Southwest Houston](https://www.expedia.ca/lp/flights/178245/6189441/calgary-to-southwest-houston) - [Flights from Dallas to Southwest Houston](https://www.expedia.ca/lp/flights/178253/6189441/dallas-to-southwest-houston) - [Flights from Detroit to Southwest Houston](https://www.expedia.ca/lp/flights/178255/6189441/detroit-to-southwest-houston) - [Flights from Seattle to Southwest Houston](https://www.expedia.ca/lp/flights/178307/6189441/seattle-to-southwest-houston) - [Visit Astrodome](https://www.expedia.ca/Houston-Astrodome.dx553248635976007975) - [Visit Southside Place](https://www.expedia.ca/Houston-Southside-Place.dx160529) - [Visit Texas Medical Center](https://www.expedia.ca/Houston-Texas-Medical-Center.dx6143504) - [Md Anderson Cancer Center](https://www.expedia.ca/MD-Anderson-Cancer-Center-Texas-Medical-Center.d6248539.Vacation-Attraction) - [Nrg Stadium](https://www.expedia.ca/NRG-Stadium-Astrodome.d553248635929331916.Vacation-Attraction) - [Alamo Rent A Car Rental Cars in Southwest Houston](https://www.expedia.ca/Alamo-Rent-A-Car-Car-Rentals-In-Southwest-Houston.d6189441-c6.Car-Rental-Guide-Suppliers) - [Global Rent a Car Rental Cars in Southwest Houston](https://www.expedia.ca/Global-Rent-A-Car-Car-Rentals-In-Southwest-Houston.d6189441-c1062.Car-Rental-Guide-Suppliers) - [Goldcar Key’n Go Rental Cars in Southwest Houston](https://www.expedia.ca/Goldcar-Keyn-Go-Car-Rentals-In-Southwest-Houston.d6189441-c1044.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Southwest Houston](https://www.expedia.ca/Hertz-Car-Rentals-In-Southwest-Houston.d6189441-c40.Car-Rental-Guide-Suppliers) - [Localiza Rental Cars in Southwest Houston](https://www.expedia.ca/Localiza-Car-Rentals-In-Southwest-Houston.d6189441-c1063.Car-Rental-Guide-Suppliers) - [Locauto Rental Cars in Southwest Houston](https://www.expedia.ca/Locauto-Car-Rentals-In-Southwest-Houston.d6189441-c1140.Car-Rental-Guide-Suppliers) - [Book Hotels in South Main on Expedia.com](https://www.expedia.com/4Star-South-Main-Houston-Hotels.s40-n553248635976386992-0.Travel-Guide-Filter-Hotels)