Title: 4 Stars Hotels in Serra Mesa, San Diego - Find Cheap Serra Mesa Hotels With 4 Stars | Expedia.ca [Serra Mesa Travel Guide](https://expedia.ca/San-Diego-Serra-Mesa.dx553248635953501652)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 4 Stars Hotels in Serra Mesa, San Diego ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Serra Mesa 4 Star Hotels Tonight [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-18&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-19&endDate=2025-10-20&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Serra Mesa 4 Star Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Serra-Mesa-San-Diego-Hotels.s40-n553248635953501652-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Serra-Mesa-San-Diego-Hotels.s40-n553248635953501652-0.Travel-Guide-Filter-Hotels) ## Top Serra Mesa Hotel Reviews ## Frequently asked questions ### What are the best 4-star hotels in Serra Mesa? > Enjoy the comfort and quality of [San Diego Marriott Mission Valley](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information). This 4-star hotel around Serra Mesa is recommended highly by many Expedia guests and features a terrace and concierge services. Another in-demand property in or close to this neighbourhood is [DoubleTree by Hilton Hotel San Diego - Mission Valley](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information). Concierge services and a terrace are two amenities that help make it popular. ### How much does it cost to stay in a 4-star hotel in Serra Mesa? > To lock in a 4-star hotel in Serra Mesa that's within your budget, use Expedia's filter tool. Browse the available options during your chosen dates and use our pricing filter to set your maximum rate. You can also list your results by the most budget-friendly stay first. > > > > - Search for the lowest price ### What's the difference between 5-star and 4-star hotels in Serra Mesa? > Offering an inviting guest experience and upmarket décor, 4-star hotels are a great option for your Serra Mesa escape. These kinds of accommodations generally feature loads of handy amenities that make it easy to unpack and recharge — think 24-hour room service, pools and gyms. Or get a taste of the high life at a 5-star hotel designed to spoil you with high-end perks and amenities. Round-the-clock concierge service, premium toiletries and gourmet dining are typically included at these plush properties. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [1 Star Hotels in San Diego](https://www.expedia.ca/1Star-San-Diego-Hotels.s10-0-d3073.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Lincoln Park](https://www.expedia.ca/2Star-Lincoln-Park-San-Diego-Hotels.s20-n797413695373639680-0.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Pacific Beach](https://www.expedia.ca/2Star-Pacific-Beach-San-Diego-Hotels.s20-n6185751-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Downtown San Diego](https://www.expedia.ca/3Star-Downtown-San-Diego-San-Diego-Hotels.s30-n800123-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Gaslamp Quarter](https://www.expedia.ca/3Star-Gaslamp-Quarter-San-Diego-Hotels.s30-n6130021-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Mid-City](https://www.expedia.ca/3Star-Mid-City-San-Diego-Hotels.s30-n553248635976388682-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in San Diego](https://www.expedia.ca/3Star-San-Diego-Hotels.s30-0-d3073.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Sunset Cliffs](https://www.expedia.ca/3Star-Sunset-Cliffs-San-Diego-Hotels.s30-n553248632557178800-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Torrey Pines](https://www.expedia.ca/3Star-Torrey-Pines-La-Jolla-Hotels.s30-n553248632557170134-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Coronado](https://www.expedia.ca/4Star-Coronado-Hotels.s40-0-d5917.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Downtown San Diego](https://www.expedia.ca/4Star-Downtown-San-Diego-San-Diego-Hotels.s40-n800123-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Fiesta Island](https://www.expedia.ca/4Star-Fiesta-Island-Hotels.s40-0-d553248621555611981.Travel-Guide-Filter-Hotels) - [4 Star Hotels in La Jolla](https://www.expedia.ca/4Star-La-Jolla-Hotels.s40-0-d6126584.Travel-Guide-Filter-Hotels) - [4 Star Hotels in La Mesa](https://www.expedia.ca/4Star-La-Mesa-Hotels.s40-0-d8484.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Pacific Beach](https://www.expedia.ca/4Star-Pacific-Beach-San-Diego-Hotels.s40-n6185751-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in San Diego](https://www.expedia.ca/4Star-San-Diego-Hotels.s40-0-d3073.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Bankers Hill](https://www.expedia.ca/5Star-Bankers-Hill-San-Diego-Hotels.s50-n553248635976473812-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Coronado](https://www.expedia.ca/5Star-Coronado-Hotels.s50-0-d5917.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Coronado Island](https://www.expedia.ca/5Star-Coronado-Island-Hotels.s50-0-d553248621532638598.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Downtown San Diego](https://www.expedia.ca/5Star-Downtown-San-Diego-San-Diego-Hotels.s50-n800123-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Gaslamp Quarter](https://www.expedia.ca/5Star-Gaslamp-Quarter-San-Diego-Hotels.s50-n6130021-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in La Jolla Farms](https://www.expedia.ca/5Star-La-Jolla-Farms-La-Jolla-Hotels.s50-n553248635976469130-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in La Jolla](https://www.expedia.ca/5Star-La-Jolla-Hotels.s50-0-d6126584.Travel-Guide-Filter-Hotels) - [5 Star Hotels in La Jolla Shores](https://www.expedia.ca/5Star-La-Jolla-Shores-La-Jolla-Hotels.s50-n553248635976008529-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in La Jolla Village](https://www.expedia.ca/5Star-La-Jolla-Village-La-Jolla-Hotels.s50-n6347758-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Mission Valley](https://www.expedia.ca/5Star-Mission-Valley-San-Diego-Hotels.s50-n800124-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in North Park](https://www.expedia.ca/5Star-North-Park-San-Diego-Hotels.s50-n6346499-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in San Diego](https://www.expedia.ca/5Star-San-Diego-Hotels.s50-0-d3073.Travel-Guide-Filter-Hotels) - [5 Star Hotels in South Park](https://www.expedia.ca/5Star-South-Park-San-Diego-Hotels.s50-n553248631819682469-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Village of La Jolla](https://www.expedia.ca/5Star-Village-Of-La-Jolla-La-Jolla-Hotels.s50-n553248635976479278-0.Travel-Guide-Filter-Hotels) - [Birdland Hotels](https://www.expedia.ca/Birdland-San-Diego-Hotels.0-n553248635976479135-0.Travel-Guide-Filter-Hotels) - [Hotels near Montgomery Field](https://www.expedia.ca/Montgomery-Field-Airport-Hotels.0-aMYF-0.Travel-Guide-Filter-Hotels) - [San Diego Hotels](https://www.expedia.ca/San-Diego-Hotels.d3073.Travel-Guide-Hotels) - [Flights to San Diego](https://www.expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights) - [Flights from Montgomery Field](https://www.expedia.ca/lp/airports/myf/flights-from-montgomery-field-airport) - [Hopscotch Air Olympia (OLM) to San Diego (MYF) flights](https://www.expedia.ca/lp/flight-routes/hopscotch-air-from-olympia-regional-to-montgomery-field/o2/olm/myf) - [Flights from Alice (ALI) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ali/myf/alice-to-san-diego) - [Flights from Amsterdam (AMS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ams/myf/amsterdam-to-san-diego) - [Flights from Bakersfield (BFL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/bfl/myf/bakersfield-to-san-diego) - [Flights from Bishop (BIH) to San Diego (MYF)](https://www.expedia.ca/lp/flights/bih/myf/bishop-to-san-diego) - [Flights from Bellingham (BLI) to San Diego (MYF)](https://www.expedia.ca/lp/flights/bli/myf/bellingham-to-san-diego) - [Flights from Boston (BOS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/bos/myf/boston-to-san-diego) - [Flights from Burlington (BTV) to San Diego (MYF)](https://www.expedia.ca/lp/flights/btv/myf/burlington-to-san-diego) - [Flights from Borrego Springs (BXS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/bxs/myf/borrego-springs-to-san-diego) - [Flights from Upland (CCB) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ccb/myf/upland-to-san-diego) - [Flights from College Park (CGS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/cgs/myf/college-park-to-san-diego) - [Flights from Clovis (CVN) to San Diego (MYF)](https://www.expedia.ca/lp/flights/cvn/myf/clovis-to-san-diego) - [Flights from Corvallis (CVO) to San Diego (MYF)](https://www.expedia.ca/lp/flights/cvo/myf/corvallis-to-san-diego) - [Flights from Calexico (CXL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/cxl/myf/calexico-to-san-diego) - [Flights from Barstow (DAG) to San Diego (MYF)](https://www.expedia.ca/lp/flights/dag/myf/barstow-to-san-diego) - [Flights from Detroit (DTT) to San Diego (MYF)](https://www.expedia.ca/lp/flights/dtt/myf/detroit-to-san-diego) - [Flights from Detroit (DTW) to San Diego (MYF)](https://www.expedia.ca/lp/flights/dtw/myf/detroit-to-san-diego) - [Flights from Douglas (DUG) to San Diego (MYF)](https://www.expedia.ca/lp/flights/dug/myf/douglas-to-san-diego) - [Flights from Newark Liberty Intl. Airport (EWR) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ewr/myf/newark-liberty-intl-airport-to-san-diego) - [Flights from Fallon (FLX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/flx/myf/fallon-to-san-diego) - [Flights from Sioux Falls (FSD) to San Diego (MYF)](https://www.expedia.ca/lp/flights/fsd/myf/sioux-falls-to-san-diego) - [Flights from Gallup (GUP) to San Diego (MYF)](https://www.expedia.ca/lp/flights/gup/myf/gallup-to-san-diego) - [Flights from Hawthorne (HHR) to San Diego (MYF)](https://www.expedia.ca/lp/flights/hhr/myf/hawthorne-to-san-diego) - [Flights from Hot Springs (HOT) to San Diego (MYF)](https://www.expedia.ca/lp/flights/hot/myf/hot-springs-to-san-diego) - [Flights from Henderson (HSH) to San Diego (MYF)](https://www.expedia.ca/lp/flights/hsh/myf/henderson-to-san-diego) - [Flights from Hayward (HWD) to San Diego (MYF)](https://www.expedia.ca/lp/flights/hwd/myf/hayward-to-san-diego) - [Flights from Indianapolis (IND) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ind/myf/indianapolis-to-san-diego) - [Flights from International Falls (INL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/inl/myf/international-falls-to-san-diego) - [Flights from El Centro (IPL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ipl/myf/el-centro-to-san-diego) - [Flights from New York (JFK) to San Diego (MYF)](https://www.expedia.ca/lp/flights/jfk/myf/new-york-to-san-diego) - [Flights from Los Angeles (LAX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/lax/myf/los-angeles-to-san-diego) - [Flights from Harrisburg (MDT) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mdt/myf/harrisburg-to-san-diego) - [Flights from Mexico City (MEX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mex/myf/mexico-city-to-san-diego) - [Flights from Milan (MIL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mil/myf/milan-to-san-diego) - [Flights from Mammoth Lakes (MMH) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mmh/myf/mammoth-lakes-to-san-diego) - [Flights from Modesto (MOD) to San Diego (MYF)](https://www.expedia.ca/lp/flights/mod/myf/modesto-to-san-diego) - [Flights from Oaxaca Intl. (OAX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/oax/myf/oaxaca-intl-to-san-diego) - [Flights from Oceanside (OCN) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ocn/myf/oceanside-to-san-diego) - [Flights from Nogales (OLS) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ols/myf/nogales-to-san-diego) - [Flights from Omaha (OMA) to San Diego (MYF)](https://www.expedia.ca/lp/flights/oma/myf/omaha-to-san-diego) - [Flights from Phoenix (PHX) to San Diego (MYF)](https://www.expedia.ca/lp/flights/phx/myf/phoenix-to-san-diego) - [Flights from Pompano Beach (PPM) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ppm/myf/pompano-beach-to-san-diego) - [Flights from Murrieta (RBK) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rbk/myf/murrieta-to-san-diego) - [Flights from Redding (RDD) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rdd/myf/redding-to-san-diego) - [Flights from Rifle (RIL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ril/myf/rifle-to-san-diego) - [Flights from Mariposa (RMY) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rmy/myf/mariposa-to-san-diego) - [Flights from Reno (RNO) to San Diego (MYF)](https://www.expedia.ca/lp/flights/rno/myf/reno-to-san-diego) - [Flights from Seattle (SEA) to San Diego (MYF)](https://www.expedia.ca/lp/flights/sea/myf/seattle-to-san-diego) - [Flights from San Francisco (SFO) to San Diego (MYF)](https://www.expedia.ca/lp/flights/sfo/myf/san-francisco-to-san-diego) - [Flights from Spearfish (SPF) to San Diego (MYF)](https://www.expedia.ca/lp/flights/spf/myf/spearfish-to-san-diego) - [Flights from San Carlos (SQL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/sql/myf/san-carlos-to-san-diego) - [Flights from Santa Paula (SZP) to San Diego (MYF)](https://www.expedia.ca/lp/flights/szp/myf/santa-paula-to-san-diego) - [Flights from Tacoma (TIW) to San Diego (MYF)](https://www.expedia.ca/lp/flights/tiw/myf/tacoma-to-san-diego) - [Flights from Temple (TPL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/tpl/myf/temple-to-san-diego) - [Flights from Watsonville (WVI) to San Diego (MYF)](https://www.expedia.ca/lp/flights/wvi/myf/watsonville-to-san-diego) - [Flights from Ottawa (YOW) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yow/myf/ottawa-to-san-diego) - [Flights from Montreal (YUL) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yul/myf/montreal-to-san-diego) - [Flights from Yuma (YUM) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yum/myf/yuma-to-san-diego) - [Flights from Vancouver (YVR) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yvr/myf/vancouver-to-san-diego) - [Flights from Vancouver (YVR) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yvr/san/vancouver-to-san-diego) - [Flights from Winnipeg (YWG) to San Diego (MYF)](https://www.expedia.ca/lp/flights/ywg/myf/winnipeg-to-san-diego) - [Flights from Calgary (YYC) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yyc/myf/calgary-to-san-diego) - [Flights from Toronto (YYZ) to San Diego (MYF)](https://www.expedia.ca/lp/flights/yyz/myf/toronto-to-san-diego) - [Flights from Toronto (YYZ) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yyz/san/toronto-to-san-diego) - [Visit Birdland](https://www.expedia.ca/San-Diego-Birdland.dx553248635976479135) - [Book Hotels in Serra Mesa on Expedia.com](https://www.expedia.com/4Star-Serra-Mesa-San-Diego-Hotels.s40-n553248635953501652-0.Travel-Guide-Filter-Hotels)