Title: 4 Stars Hotels in Serra Mesa, San Diego from CA $182 - Find Cheap Serra Mesa Hotels With 4 Stars | Expedia.ca [Serra Mesa Travel Guide](https://expedia.ca/San-Diego-Serra-Mesa.dx553248635953501652)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Serra Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Serra-Mesa.d553248635953501652.Car-Rental-Guide)[Serra Mesa Vacations](https://expedia.ca/Serra-Mesa.d553248635953501652.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 4 Stars Hotels in Serra Mesa, San Diego from CA $182 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Serra Mesa 4 Star Hotels Tonight [Oct 4 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-04&endDate=2025-10-05&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 5 - Oct 6](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-05&endDate=2025-10-06&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635953501652&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Serra Mesa 4 Star Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/b173351e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch TV with cable channels, Netflix, streaming services](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/ad56ea36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![The Views Ocean View Suite 1 King](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/a72d9dc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel del Coronado, Curio Collection by Hilton Historic Downtown Coronado 8.2/10 Very good (1003) "It was a great place to stay . " CA $434 CA $560 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/88f9cd22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/d5ea2f3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/7f3bc7ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham San Diego Bayside Downtown San Diego 8.4/10 Very good (5958) "Great stay near the airport." CA $212 CA $287 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/4480f6ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/a314a493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/881441d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/dd3cca67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palihotel San Diego Gaslamp Quarter Downtown San Diego 8.8/10 Excellent (1873) "would definitely stay again!" CA $157 CA $182 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/San-Diego-Hotels-Palihotel-San-Diego.h88398416.Hotel-Information) ![6 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/w3840h2092x0y3-447c77a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/c62939cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/f2bcf3e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/w3836h2560x4y0-6c8cb0de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Manchester Grand Hyatt San Diego Downtown San Diego 9.0/10 Wonderful (2833) "Great area to explore" CA $347 CA $479 total includes taxes & fees Oct 10 - Oct 11 [](https://www.expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/23e38216.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/d85ecd0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/7e147d0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hard Rock Hotel San Diego Downtown San Diego 9.0/10 Wonderful (2974) "Loved staying here. Will definitely stay again " CA $250 CA $354 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/5afe6cec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/ad83f8b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 10 PM, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/e1632942.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/b3ef3ceb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton San Diego - Del Mar Carmel Valley 8.2/10 Very good (1633) "Enjoyed staying here" CA $174 CA $199 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2d82864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/a3c5905c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/99024d06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2540b7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loews Coronado Bay Resort Silver Strand 8.8/10 Excellent (1037) "Beautiful quiet hotel." CA $278 CA $372 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) ![Room, 1 King Bed with Sofa bed, Marina View | View from room](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, lunch, dinner served; Mexican cuisine](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/b3296075.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/086855c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/1e020b70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton San Diego Resort Harbor Island 8.2/10 Very good (3080) "Great hotel " CA $236 CA $321 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5400/5328/cfe599b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5400/5328/451480f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/5400/5328/85a135ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed | Living area](https://images.trvl-media.com/lodging/1000000/10000/5400/5328/d22de167.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites by Hilton San Diego Bay Downtown Downtown San Diego 9.0/10 Wonderful (1451) "Its a very nice hotel to stay at.. very convenient " CA $296 CA $394 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-Bay-Downtown.h5328.Hotel-Information) ![Outdoor pool, open 9:00 AM to 9:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/bbcdbd6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/c2cecb91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand, windsurfing, beach volleyball](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/c20f7d47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/eae398b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Mission Bay Resort San Diego 8.4/10 Very good (1289) "Nice place " CA $347 CA $462 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/a9075ad6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 5:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/7806cdf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/169b339e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Bay View (Spacious, King Bed) | View from room](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/8cc93949.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni San Diego Hotel at the Ballpark Downtown San Diego 9.2/10 Wonderful (2012) "Love this hotel, wonderful staff and location " CA $336 CA $453 total includes taxes & fees Oct 11 - Oct 12 [](https://www.expedia.ca/San-Diego-Hotels-Omni-San-Diego-Hotel.h982408.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/bf663de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/a7d908f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/fa05a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Little Italy Hotel Downtown San Diego Downtown San Diego 8.2/10 Very good (1065) "Loved this location. " CA $194 CA $225 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/7c71b256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/a9d5662a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/7fe47de0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Paradise Point Resort & Spa San Diego 8.6/10 Excellent (2287) "Great spot right on the bay, Been there forever which is part of the charm." CA $271 CA $382 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/49079311.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/25bf8c88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/387cb6b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/6013e99c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites by Hilton San Diego La Jolla University City 8.8/10 Excellent (1716) "Very friendly staff and excellent breakfast " CA $308 CA $354 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/1de80c10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/df29ea56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/bd692b4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Mission Valley Mission Valley 8.0/10 Very good (2029) "Clean rooms, easy access, friendly and helpful staff. Very good stay!" CA $175 CA $201 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/1b87fc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hospitality Suite, 1 King Bed, Bay View | Living room](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/d02824a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby, white sand](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/31f9c777.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/ca66f35a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin San Diego Bayview Downtown San Diego 8.6/10 Excellent (1014) "Clean room, nice staff, and walkable to restaurants! " CA $262 CA $339 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Diego-Hotels-The-Westin-San-Diego-Downtown.h27516.Hotel-Information) ![2 outdoor pools, open 6 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/9078a9ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/eb8b9673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/80be4d0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/5488e3f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Marquis San Diego Marina Downtown San Diego 9.2/10 Wonderful (1869) "Great For family getaway" CA $307 CA $419 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information) ![Daily buffet breakfast for a fee](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/332/6ddceb14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/400/332/e4705932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/332/771038f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel San Diego - Mission Valley Mission Valley 8.2/10 Very good (1288) "Great hotel. Clean,quiet,and great staff" CA $187 CA $215 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Outdoor pool, open 7:00 AM to 9:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/91a184a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/56fafd1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/116e1fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/abbee14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lafayette Hotel & Club University Heights 9.4/10 Exceptional (1186) "Amazing, celebrated my birthday here with girlfriends and it was everything and more!" CA $315 CA $362 total includes taxes & fees Oct 6 - Oct 7 [](https://www.expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/858/c5325c92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse](https://images.trvl-media.com/lodging/1000000/10000/900/858/36c2b78d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/900/858/93b051f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/900/858/c6795882.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Mission Bay Spa and Marina San Diego 8.4/10 Very good (1538) "Clean rooms great view amazing pool and we loved the breakfast " CA $212 CA $318 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Serra-Mesa-San-Diego-Hotels.s40-n553248635953501652-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Serra-Mesa-San-Diego-Hotels.s40-n553248635953501652-0.Travel-Guide-Filter-Hotels) ## Explore similar 5-star hotels Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Serra Mesa. ![Pendry San Diego](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Pendry San Diego 550 J Street, San Diego, CA CA $356 CA $486 total Oct 29 - Oct 30 includes taxes & fees 9.2/10 Wonderful! (1,001 reviews) [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![The US Grant, a Luxury Collection Hotel, San Diego](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/e71c0bc8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The US Grant, a Luxury Collection Hotel, San Diego 326 Broadway, San Diego, CA CA $388 CA $450 total Oct 19 - Oct 20 includes taxes & fees 9/10 Wonderful! (1,000 reviews) [](https://expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information) ![L'Auberge Del Mar](https://images.trvl-media.com/lodging/1000000/10000/5100/5079/2994db0e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### L'Auberge Del Mar 1540 Camino Del Mar, Del Mar, CA CA $557 CA $726 total Oct 5 - Oct 6 includes taxes & fees 8.6/10 Excellent! (807 reviews) [](https://expedia.ca/Del-Mar-Hotels-LAuberge-Del-Mar.h5079.Hotel-Information) Still don't see what you're looking for? [See all properties in Serra Mesa.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F10%2F2025&endDate=06%2F10%2F2025®ionId=553248635953501652&star=40) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F10%2F2025&endDate=06%2F10%2F2025®ionId=553248635953501652&star=40&star=40&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F10%2F2025&endDate=06%2F10%2F2025®ionId=553248635953501652&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F10%2F2025&endDate=06%2F10%2F2025®ionId=553248635953501652&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F10%2F2025&endDate=06%2F10%2F2025®ionId=553248635953501652&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=05%2F10%2F2025&endDate=06%2F10%2F2025®ionId=553248635953501652&star=40&star=40&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Serra Mesa Hotel Reviews ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Stay was excellent room always cleaned and beds made promptly. Room was very spacious and view of the bay with balcony amazing. Location is excellent." [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Clean room" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Great ocean view located right on wide beach. Hotel is awesome." [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Manchester Grand Hyatt San Diego](//images.trvl-media.com/lodging/1000000/20000/12100/12073/w3840h2092x0y3-447c77a4_y.jpg) ### Manchester Grand Hyatt San Diego 10/10 Excellent "The Manchester Grand Hyatt is our go to hotel in San Diego due to its convenient location by the Seaport Village and many restaurants and shops. We have stayed there several times and always enjoy the scenic views from our room and the hospitality of the hotel staff. The breakfast buffet has a large variety of offerings including an omelette station. The MarketOne Cafe downstairs has many items including delicious pastries and other food and drink items. It is always a great experience to stay at the Manchester Grand Hyatt in San Diego." [](https://expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![Legacy Resort Hotel & Spa](//images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4_y.jpg) ### Legacy Resort Hotel & Spa 10/10 Excellent "Staff were extremely helpful and kind. Room was so clean and quiet. These were the most comfortable hotel beds we have ever slept on. It is a great location for dining and shopping and just about everything else in San Diego, except the beach. Great experience!" [](https://expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![DoubleTree by Hilton San Diego - Del Mar](//images.trvl-media.com/lodging/1000000/20000/15300/15236/5afe6cec_y.jpg) ### DoubleTree by Hilton San Diego - Del Mar 10/10 Excellent "Nice place with friendly staff" [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Close to freeway restaurants and stores " [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Palihotel San Diego Gaslamp Quarter](//images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/4480f6ef_y.jpg) ### Palihotel San Diego Gaslamp Quarter 10/10 Excellent "Clean & cozy room, friendly staff, amazing restraunt and mini-bar options" [](https://expedia.ca/San-Diego-Hotels-Palihotel-San-Diego.h88398416.Hotel-Information) ![San Diego Marriott La Jolla](//images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107_y.jpg) ### San Diego Marriott La Jolla 10/10 Excellent "Great location right by the freeway, and there is a mall within walking distance" [](https://expedia.ca/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) ## Frequently asked questions ### What are the best 4-star hotels in Serra Mesa? > Enjoy the comfort and quality of [San Diego Marriott Mission Valley](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information). This 4-star hotel around Serra Mesa is recommended highly by many Expedia guests and features a terrace and concierge services. Another in-demand property in or close to this neighbourhood is [DoubleTree by Hilton Hotel San Diego - Mission Valley](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information). Concierge services and a terrace are two amenities that help make it popular. ### How much does it cost to stay in a 4-star hotel in Serra Mesa? > To lock in a 4-star hotel in Serra Mesa that's within your budget, use Expedia's filter tool. Browse the available options during your chosen dates and use our pricing filter to set your maximum rate. You can also list your results by the most budget-friendly stay first. > > > > - Search for the lowest price from CA $450 ### What's the difference between 5-star and 4-star hotels in Serra Mesa? > Offering an inviting guest experience and upmarket décor, 4-star hotels are a great option for your Serra Mesa escape. These kinds of accommodations generally feature loads of handy amenities that make it easy to unpack and recharge — think 24-hour room service, pools and gyms. Or get a taste of the high life at a 5-star hotel designed to spoil you with high-end perks and amenities. Round-the-clock concierge service, premium toiletries and gourmet dining are typically included at these plush properties. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [1 Star Hotels in San Diego](https://www.expedia.ca/1Star-San-Diego-Hotels.s10-0-d3073.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Lincoln Park](https://www.expedia.ca/2Star-Lincoln-Park-San-Diego-Hotels.s20-n797413695373639680-0.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Pacific Beach](https://www.expedia.ca/2Star-Pacific-Beach-San-Diego-Hotels.s20-n6185751-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Downtown San Diego](https://www.expedia.ca/3Star-Downtown-San-Diego-San-Diego-Hotels.s30-n800123-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Gaslamp Quarter](https://www.expedia.ca/3Star-Gaslamp-Quarter-San-Diego-Hotels.s30-n6130021-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Mid-City](https://www.expedia.ca/3Star-Mid-City-San-Diego-Hotels.s30-n553248635976388682-0.Travel-Guide-Filter-Hotels) - 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