Beginning of main content

4 stars Hotels in Panama, Panama

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Panama Hotels

Search Flight + Hotel

Advanced options

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Panama 4 stars Hotels

See all 432 Hotels in Panama
Radisson Decapolis Panama City
Radisson Decapolis Panama City
Avenida Balboa Con Multicentro, Panama City
4.0 out of 5.0
4.4 out of 5 (249 reviews)
Hide review
Great location if you want to shop and enjoy good food
  21 May 2017

C$141

C$141
Wyndham Panama Albrook Mall
Wyndham Panama Albrook Mall
Ave. Marginal, Corregimiento de Ancon, Panama City
4.0 out of 5.0
4.4 out of 5 (246 reviews)
Hide review
When I need to go into the city The hotel is perfect. It is located in the mall , next door to the canal , has attachments to whatever you need in the city. Staff will do whatever is needed to make your stay great !
  18 May 2017

C$141

C$141
Hard Rock Hotel Panama Megapolis
Hard Rock Hotel Panama Megapolis
Ave. Balboa al lado de Multicentro, Panama City
4.5 out of 5.0
4.1 out of 5 (718 reviews)
Hide review
A megapolis tower Everything was great. Nice views of the city, the overwhelming choice of food in the bazaar restaurant.
  22 May 2017

C$184

C$184
Radisson Summit Hotel and Golf Panama
Radisson Summit Hotel and Golf Panama
Omar Torrijos Ave, Paraiso
4.0 out of 5.0
4.2 out of 5 (203 reviews)
Hide review
Great rainforest location! Very comfortable hotel. Great views in the middle of the rainforest. Fun challenging golf course🏌️
  24 May 2017

C$88

C$88
American Trade Hotel
American Trade Hotel
Plaza Herrera Casco Viejo, Panama City
4.5 out of 5.0
4.9 out of 5 (40 reviews)
Hide review
Great Location in Casa Viejo Updated Old Panama City flavor with modern amenities. Staff went out of their way to help with any request. Would stay again.
  8 May 2017

C$233

C$233
Panama Marriott Hotel
Panama Marriott Hotel
52nd St. and Ricardo Arias, Panama City
4.0 out of 5.0
4.4 out of 5 (67 reviews)
Hide review
Good hotel, breakfast buffet delicious! Clean rooms. Needs a little update on the lobby decoration though. It's a "classic" style hotel
  24 Apr 2017

C$155

C$155
DeVille Hotel Boutique
DeVille Hotel Boutique
50 street and Beatriz M. De Cabal, Panama City
4.0 out of 5.0
4.3 out of 5 (97 reviews)
Hide review
Service level not what it used to be. Night manager doesn't speak English, area becomes more prostitute-infested at night which can make it scary.
  20 May 2017

C$66

C$66
Bocas del Mar Hotel
Bocas del Mar Hotel
Road to Boca Chica, Boca Chica
4.0 out of 5.0
4.9 out of 5 (29 reviews)
Hide review
Very nice hotel with an amazing staff. We enjoyed our stay. Very relaxing place in a remote location. Certainly not touristy. Beautiful views of the ocean. The staff was extremely welcoming, friendly and accomendating. Room was clean and beds very comfortable. We'll definitely be back.
  1 May 2017

C$188

C$188
Hilton Panama
Hilton Panama
Balboa Ave. and Aquilino De La Guardia, Panama City
4.5 out of 5.0
4.5 out of 5 (64 reviews)
Hide review
Clean and quiet View from breakfast lounge was nice. Check in lobby was so spacious.
  6 May 2017

C$188

C$188
Sortis Hotel, Spa & Casino, Autograph Collection
Sortis Hotel, Spa & Casino, Autograph Collection
56 y 57 East Street, Obarrio, Panama City
4.5 out of 5.0
4.4 out of 5 (64 reviews)
Hide review
In the middle of the city nice restaurants In the middle of the city nice restaurants wonderful swimming pool area.
  16 Apr 2017

C$162

C$162
Map

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 stars hotels in Panama are calling your name. Known for providing first-rate service in amazing locations, each of the Panama 4 stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Panama. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 stars hotel in Panama, Panama, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Panama hotels with 4 stars provide everything you need to unwind in style.

Recently booked Panama hotels

Novotel Panama City
4.0 out of 5.0
Last booking: 18 minutes ago
Radisson Summit Hotel and Golf Panama
4.0 out of 5.0
Last booking: 37 minutes ago