Title: 4 Stars Hotels in Melrose, Natchez - Find Cheap Melrose Hotels With 4 Stars | Expedia.ca [Melrose Travel Guide](https://expedia.ca/Melrose.dx553248635975870440)[Hotels in Melrose](https://expedia.ca/Melrose-Hotels.d553248635975870440.Travel-Guide-Hotels)[Vacation Rentals in Melrose](https://expedia.ca/Melrose-Vacation-Rentals.d553248635975870440.Travel-Guide-VacationRentals)[Flights to Melrose](https://expedia.ca/Cheap-Flights-To-Melrose.d553248635975870440.Travel-Guide-Flights)[Melrose Car Rentals](https://expedia.ca/Car-Rentals-In-Melrose.d553248635975870440.Car-Rental-Guide)[Melrose Vacation Packages](https://expedia.ca/Melrose.d553248635975870440.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 4 Stars Hotels in Melrose, Natchez - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Melrose 4 Star Hotels Tonight [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635975870440&startDate=2025-12-13&endDate=2025-12-14&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=553248635975870440&startDate=2025-12-14&endDate=2025-12-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635975870440&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635975870440&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Melrose 4-star hotels ![Front of property](https://images.trvl-media.com/lodging/91000000/90330000/90324200/90324108/588f2472.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch TV with digital channels, Netflix, Hulu](https://images.trvl-media.com/lodging/91000000/90330000/90324200/90324108/cce87eb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch TV with digital channels, Netflix, Hulu](https://images.trvl-media.com/lodging/91000000/90330000/90324200/90324108/66fcf9af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch TV with digital channels, Netflix, Hulu](https://images.trvl-media.com/lodging/91000000/90330000/90324200/90324108/b24a8017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Opus House [](https://www.expedia.ca/Natchitoches-Hotels-Opus-House.h90324108.Hotel-Information) Natchitoches 10/10 Exceptional (15) "Excellent room and location to downtown Natchitoches" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sarah [](https://www.expedia.ca/Natchitoches-Hotels-Opus-House.h90324108.Hotel-Information) ![Executive Suite](https://images.trvl-media.com/lodging/17000000/16160000/16151000/16150981/a8da4ad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/17000000/16160000/16151000/16150981/b1199fb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/17000000/16160000/16151000/16150981/80cf960f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Suite](https://images.trvl-media.com/lodging/17000000/16160000/16151000/16150981/fe20cadf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Good House B&B [](https://www.expedia.ca/Natchitoches-Hotels-The-Good-House-Bed-And-Breakfast.h16150981.Hotel-Information) Natchitoches 9.4/10 Exceptional (40) "Every thing went very well. Cheryl and Ken are great hosts. We were very comfortable. Would highly recommend this property. Ken is a veteran so we had a lot in common to talk about. Would definitely stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lonnie [](https://www.expedia.ca/Natchitoches-Hotels-The-Good-House-Bed-And-Breakfast.h16150981.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Melrose-Hotels.s40-0-d553248635975870440.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Melrose-Hotels.s40-0-d553248635975870440.Travel-Guide-Filter-Hotels) ## Top Melrose Hotel Reviews ![Opus House ](https://images.trvl-media.com/lodging/91000000/90330000/90324200/90324108/b4c7a3f2_y.jpg) ### Opus House 10/10 Excellent "Cole and Denise are great hosts. Our actual stay went way beyond our expectations." [](https://expedia.ca/Natchitoches-Hotels-Opus-House.h90324108.Hotel-Information) ## Find out more about Melrose If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Melrose are calling your name. Known for providing first-rate service in amazing locations, each of the Melrose 4 Stars hotels lets discerning travelers bask in an unforgettable experience. Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day. It’s all waiting for you at the top four star hotels in Melrose. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Melrose, Natchez, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Melrose hotels with 4 Stars provide everything you need to unwind in style. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [2 Star Hotels in Logansport ](https://www.expedia.ca/2Star-Logansport-Hotels.s20-0-d553248634999105164.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Grand Cane ](https://www.expedia.ca/3Star-Grand-Cane-Hotels.s30-0-d3000439319.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Red Chute ](https://www.expedia.ca/3Star-Red-Chute-Hotels.s30-0-d553248634999396763.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Baskin ](https://www.expedia.ca/4Star-Baskin-Hotels.s40-0-d553248634998906730.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Frierson ](https://www.expedia.ca/4Star-Frierson-Hotels.s40-0-d553248635974902937.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Haughton ](https://www.expedia.ca/4Star-Haughton-Hotels.s40-0-d553248634999003152.Travel-Guide-Filter-Hotels) - 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