Title: 4 Stars Hotels in Lake Nona Medical City, Orlando from CA $134 - Find Cheap Lake Nona Medical City Hotels With 4 Stars | Expedia.ca [Lake Nona Medical City Travel Guide](https://expedia.ca/Orlando-Lake-Nona-Medical-City.dx6197057)[Vacation Rentals in Orlando](https://expedia.ca/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals)[Flights to Orlando](https://expedia.ca/Cheap-Flights-To-Orlando.d178294.Travel-Guide-Flights)[Things to do in Orlando](https://expedia.ca/Things-To-Do-In-Orlando.d178294.Travel-Guide-Activities)[Lake Nona Medical City Car Rentals](https://expedia.ca/Car-Rentals-In-Lake-Nona-Medical-City.d6197057.Car-Rental-Guide)[Lake Nona Medical City Vacations](https://expedia.ca/Lake-Nona-Medical-City.d6197057.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 4 Stars Hotels in Lake Nona Medical City, Orlando from CA $134 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Lake Nona Medical City 4 Star Hotels Tonight [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-12-27&endDate=2025-12-28&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 28 - Dec 29](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-12-28&endDate=2025-12-29&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2026-01-02&endDate=2026-01-04&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2026-01-09&endDate=2026-01-11&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Lake Nona Medical City 4-star hotels ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/5400/5398/4997b5df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![50-inch flat-screen TV with cable channels, TV, pay movies](https://images.trvl-media.com/lodging/1000000/10000/5400/5398/7f4a5e94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/10000/5400/5398/a43383ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms](https://images.trvl-media.com/lodging/1000000/10000/5400/5398/f911355a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton at the Entrance to Universal Orlando [](https://www.expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-At-The-Entrance-To-Universal-Orlando.h5398.Hotel-Information) Florida Center 8.4/10 Very good (6882) "Great hotel great food" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Malika CA $122 CA $137 total includes taxes & fees Jan 15 - Jan 16, 2026 [](https://www.expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-At-The-Entrance-To-Universal-Orlando.h5398.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/2800/2754/acaa1e8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/2800/2754/w5757h3835x0y5-1b070edd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/2800/2754/b16b92f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/10000/2800/2754/w5752h3835x5y5-c0622ec3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Orlando International Airport [](https://www.expedia.ca/Orlando-Hotels-Hyatt-Regency-Orlando-International-Airport.h2754.Hotel-Information) Orlando 9.4/10 Exceptional (3850) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dan CA $272 CA $306 total includes taxes & fees Dec 31 - Jan 1, 2026 [](https://www.expedia.ca/Orlando-Hotels-Hyatt-Regency-Orlando-International-Airport.h2754.Hotel-Information) ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/9600/9574/1bb0a2ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Suite](https://images.trvl-media.com/lodging/1000000/10000/9600/9574/w3836h2561x4y0-0f34b0cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/10000/9600/9574/d087c6a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Larger Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/9600/9574/w3836h2561x4y0-4e4ef6a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Orlando [](https://www.expedia.ca/Orlando-Hotels-Hyatt-Regency-Orlando.h9574.Hotel-Information) International Drive District 9.2/10 Wonderful (1889) "Clean and beautifully maintained hotel . " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Puneet CA $184 CA $282 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/Orlando-Hotels-Hyatt-Regency-Orlando.h9574.Hotel-Information) ![3 outdoor pools, open 6:00 AM to 11:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/20000/12800/12710/a6b6c49c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/12800/12710/be188a03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/12800/12710/9aed5673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12800/12710/af138ba9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walt Disney World Dolphin [](https://www.expedia.ca/Orlando-Hotels-Walt-Disney-World-Dolphin.h12710.Hotel-Information) Bay Lake 8.8/10 Excellent (4011) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven CA $277 CA $380 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/Orlando-Hotels-Walt-Disney-World-Dolphin.h12710.Hotel-Information) ![6 outdoor pools, free cabanas, pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/23200/23110/ade3b60d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23200/23110/b969c931.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children's play area - outdoor](https://images.trvl-media.com/lodging/1000000/30000/23200/23110/5799425f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/23200/23110/dadb3c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando [](https://www.expedia.ca/Orlando-Hotels-Sheraton-Vistana-Resort-Villas.h23110.Hotel-Information) Orlando 9.4/10 Exceptional (4179) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jude CA $152 CA $171 total includes taxes & fees Jan 19 - Jan 20, 2026 [](https://www.expedia.ca/Orlando-Hotels-Sheraton-Vistana-Resort-Villas.h23110.Hotel-Information) ![2 outdoor pools, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/11700/11652/0a79f404.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/11700/11652/26a93607.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/11700/11652/5c17b7f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/20000/11700/11652/a2164a16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Orlando Lake Buena Vista - Disney Springs® Area [](https://www.expedia.ca/Orlando-Hotels-Hilton-Orlando-Lake-Buena-Vista-Disney-Springs-Area.h11652.Hotel-Information) Lake Buena Vista 8.6/10 Excellent (1461) "Perfect hotel to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dennis CA $207 CA $296 total includes taxes & fees Jan 8 - Jan 9, 2026 [](https://www.expedia.ca/Orlando-Hotels-Hilton-Orlando-Lake-Buena-Vista-Disney-Springs-Area.h11652.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/18900/18874/69019073.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/20000/18900/18874/36cc72cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools, open 6:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/20000/18900/18874/ae19ad1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/18900/18874/3b1fab54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel Orlando at SeaWorld [](https://www.expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Hotel-Orlando-At-SeaWorld.h18874.Hotel-Information) International Drive District 7.6/10 Good (6319) "Clean room, the breakfast buffet was great, and the pool area was beautiful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandon CA $95 CA $145 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Hotel-Orlando-At-SeaWorld.h18874.Hotel-Information) ![5 outdoor pools, free cabanas, pool umbrellas](https://images.trvl-media.com/lodging/1000000/540000/539500/539487/88f9edce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/540000/539500/539487/fbdaf42b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, 2 poolside bars](https://images.trvl-media.com/lodging/1000000/540000/539500/539487/1d682714.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/540000/539500/539487/9cdafc45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Vistana Villages Resort Villas, I-Drive/Orlando [](https://www.expedia.ca/Orlando-Hotels-Sheraton-Vistana-Villages-Resort-Villas.h539487.Hotel-Information) International Drive District 9.2/10 Wonderful (2809) "Great stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JULIA D CA $180 CA $203 total includes taxes & fees Jan 20 - Jan 21, 2026 [](https://www.expedia.ca/Orlando-Hotels-Sheraton-Vistana-Villages-Resort-Villas.h539487.Hotel-Information) ![2 outdoor pools, open 6:00 AM to 11:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/10000/9700/9665/542ce6b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, individually decorated](https://images.trvl-media.com/lodging/1000000/10000/9700/9665/ee646229.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9700/9665/e8871666.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/10000/9700/9665/add73b47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Lake Buena Vista at Vista Centre [](https://www.expedia.ca/Orlando-Hotels-Courtyard-By-Marriott-Lake-Buena-Vista-At-Vista-Centre.h9665.Hotel-Information) Orlando 8.2/10 Very good (1424) "Friendly staff, clean and comfortable room." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $108 CA $137 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Orlando-Hotels-Courtyard-By-Marriott-Lake-Buena-Vista-At-Vista-Centre.h9665.Hotel-Information) ![4 outdoor pools, open 5:30 AM to midnight, cabanas (surcharge)](https://images.trvl-media.com/lodging/2000000/1470000/1460500/1460425/cca9a672.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![11 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/2000000/1470000/1460500/1460425/a5c2174b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/2000000/1470000/1460500/1460425/2ac14176.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1470000/1460500/1460425/eadb38ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rosen Shingle Creek [](https://www.expedia.ca/Orlando-Hotels-Rosen-Shingle-Creek.h1460425.Hotel-Information) Orlando 9.4/10 Exceptional (4385) "Great place to stay. Definitely will stay here again.." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donnell CA $140 CA $158 total includes taxes & fees Jan 23 - Jan 24, 2026 [](https://www.expedia.ca/Orlando-Hotels-Rosen-Shingle-Creek.h1460425.Hotel-Information) ![4 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/900000/891000/890951/0b826e24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, stovetop, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/900000/891000/890951/fefe03d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/1000000/900000/891000/890951/6bd9ae14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/891000/890951/89cc4422.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Vacation Club Mystic Dunes Orlando [](https://www.expedia.ca/Orlando-Hotels-Mystic-Dunes-Resort-Golf-Club-By-Diamond-Resorts.h890951.Hotel-Information) Kissimmee 9.0/10 Wonderful (4519) "Clean room, staff was great at check in. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda Lee CA $137 CA $202 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/Orlando-Hotels-Mystic-Dunes-Resort-Golf-Club-By-Diamond-Resorts.h890951.Hotel-Information) ![4 outdoor pools, open 7:00 AM to 11:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/860000/853600/853519/77708f65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/860000/853600/853519/b83a90af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/860000/853600/853519/48c854e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/860000/853600/853519/bb132b7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott's Grande Vista [](https://www.expedia.ca/Orlando-Hotels-Marriotts-Grande-Vista.h853519.Hotel-Information) Orlando 9.0/10 Wonderful (3726) "Very good place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Makenlove CA $163 CA $183 total includes taxes & fees Jan 25 - Jan 26, 2026 [](https://www.expedia.ca/Orlando-Hotels-Marriotts-Grande-Vista.h853519.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12300/12270/46c74ea6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/12300/12270/c5a5836c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/12300/12270/63917586.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/12300/12270/fb8d2763.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Orlando Airport [](https://www.expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Orlando-Airport.h12270.Hotel-Information) Airport North 8.8/10 Excellent (2207) "Great hotel! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $201 CA $226 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Orlando-Airport.h12270.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/25000000/24060000/24054800/24054711/5f422c24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24060000/24054800/24054711/a9cabc8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24060000/24054800/24054711/46754a1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/25000000/24060000/24054800/24054711/1ec1f9ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Resort Orlando [](https://www.expedia.ca/Orlando-Hotels-Margaritaville-Resort-Orlando.h24054711.Hotel-Information) Kissimmee 8.8/10 Excellent (3628) "We love staying at this hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sonnia CA $181 CA $280 total includes taxes & fees Jan 6 - Jan 7, 2026 [](https://www.expedia.ca/Orlando-Hotels-Margaritaville-Resort-Orlando.h24054711.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/7400/7372/1c333323.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to midnight, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/7400/7372/76e724ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/7400/7372/b28f041c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds | Bathroom](https://images.trvl-media.com/lodging/1000000/10000/7400/7372/cdca0762.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rosen Plaza on International Drive [](https://www.expedia.ca/Orlando-Hotels-Rosen-Plaza-On-International-Drive.h7372.Hotel-Information) International Drive District 9.2/10 Wonderful (1792) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joshua CA $140 CA $162 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Orlando-Hotels-Rosen-Plaza-On-International-Drive.h7372.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/3900/3832/b0f81967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee shop](https://images.trvl-media.com/lodging/1000000/10000/3900/3832/015972bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/10000/3900/3832/c7481f32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/3900/3832/52b0791d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Avanti International Resort [](https://www.expedia.ca/Orlando-Hotels-Avanti-International-Resort.h3832.Hotel-Information) International Drive District 7.8/10 Good (4346) "Enjoyed our stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sheltra CA $95 CA $134 total includes taxes & fees Jan 26 - Jan 27, 2026 [](https://www.expedia.ca/Orlando-Hotels-Avanti-International-Resort.h3832.Hotel-Information) ![Room, 1 King Bed, Corner](https://images.trvl-media.com/lodging/1000000/20000/10600/10565/cdfd5651.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/10600/10565/bd5dfbbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/20000/10600/10565/2fdce040.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10600/10565/833385b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel Orlando Downtown [](https://www.expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Orlando-Downtown.h10565.Hotel-Information) Ivanhoe Village 8.2/10 Very good (2924) "Excellent hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maite CA $158 CA $178 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Orlando-Downtown.h10565.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40900/40865/075cd42b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bicycling](https://images.trvl-media.com/lodging/1000000/50000/40900/40865/2d5ed892.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, lunch, dinner served; Italian cuisine](https://images.trvl-media.com/lodging/1000000/50000/40900/40865/3d0051dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40865/w3836h2561x3y0-6cfb6f06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caribe Royale Orlando [](https://www.expedia.ca/Orlando-Hotels-Caribe-Royale-Orlando.h40865.Hotel-Information) Orlando 9.2/10 Wonderful (4528) "excellent place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arshad CA $240 CA $328 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/Orlando-Hotels-Caribe-Royale-Orlando.h40865.Hotel-Information) ![Outdoor pool, open 6:00 AM to midnight, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/11500/11432/016c4706.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11500/11432/bf2d7277.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/11500/11432/51a5e50f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/20000/11500/11432/6c009aed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rosen Centre Hotel [](https://www.expedia.ca/Orlando-Hotels-Rosen-Centre-Hotel.h11432.Hotel-Information) International Drive District 9.0/10 Wonderful (4158) "The hotel was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robin CA $137 CA $156 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Orlando-Hotels-Rosen-Centre-Hotel.h11432.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/201100/201033/af95e25a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/210000/201100/201033/6cb4d945.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/201100/201033/60fcc042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/210000/201100/201033/d8baaaf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Universal’s Loews Portofino Bay Hotel [](https://www.expedia.ca/Orlando-Hotels-Universals-Loews-Portofino-Bay-Hotel.h201033.Hotel-Information) Florida Center 9.0/10 Wonderful (1001) "Excellent staff restaurants and rooms! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Catherine CA $753 CA $848 total includes taxes & fees Jan 25 - Jan 26, 2026 [](https://www.expedia.ca/Orlando-Hotels-Universals-Loews-Portofino-Bay-Hotel.h201033.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Lake-Nona-Medical-City-Orlando-Hotels.s40-n6197057-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Lake-Nona-Medical-City-Orlando-Hotels.s40-n6197057-0.Travel-Guide-Filter-Hotels) ## Explore similar 5-star hotels Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Lake Nona Medical City. ![Waldorf Astoria Orlando - An Official Walt Disney World® Hotel](https://images.trvl-media.com/lodging/3000000/2440000/2432800/2432727/0589fd64_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Waldorf Astoria Orlando - An Official Walt Disney World® Hotel 14200 Bonnet Creek Resort Lane Orlando FL CA $528 CA $670 total Jan 10 - Jan 11, 2026 includes taxes & fees 9.2/10 Wonderful! (431 reviews) [](https://expedia.ca/Orlando-Hotels-Waldorf-Astoria-Orlando.h2432727.Hotel-Information) ![Conrad Orlando at Evermore](https://images.trvl-media.com/lodging/91000000/90610000/90603800/90603710/9dffefcc_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Conrad Orlando at Evermore 1500 Eastbeach Way Orlando FL CA $829 CA $1,000 total Jan 10 - Jan 11, 2026 includes taxes & fees 9.4/10 Exceptional! (344 reviews) [](https://expedia.ca/Orlando-Hotels-Conrad-Orlando.h90603710.Hotel-Information) ![Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort](https://images.trvl-media.com/lodging/8000000/7380000/7374500/7374428/d1187640_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort 10100 Dream Tree Blvd. Lake Buena Vista FL CA $1,442 CA $1,700 total Jan 19 - Jan 20, 2026 includes taxes & fees 9.6/10 Exceptional! (877 reviews) [](https://expedia.ca/Orlando-Hotels-Four-Seasons-Resort-Orlando-At-WALT-DISNEY-WORLD-Resort.h7374428.Hotel-Information) Still don't see what you're looking for? [See all properties in Lake Nona Medical City.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F12%2F2025&endDate=29%2F12%2F2025®ionId=6197057&star=40) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F12%2F2025&endDate=29%2F12%2F2025®ionId=6197057&star=40&star=40&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F12%2F2025&endDate=29%2F12%2F2025®ionId=6197057&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F12%2F2025&endDate=29%2F12%2F2025®ionId=6197057&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F12%2F2025&endDate=29%2F12%2F2025®ionId=6197057&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F12%2F2025&endDate=29%2F12%2F2025®ionId=6197057&star=40&star=40&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Lake Nona Medical City Hotel Reviews ![Sheraton Vistana Villages Resort Villas, I-Drive/Orlando](https://images.trvl-media.com/lodging/1000000/540000/539500/539487/88f9edce_y.jpg) ### Sheraton Vistana Villages Resort Villas, I-Drive/Orlando 10/10 Excellent "Very clean easy and great service lots of amenities and great pools great location as well " [](https://expedia.ca/Orlando-Hotels-Sheraton-Vistana-Villages-Resort-Villas.h539487.Hotel-Information) ![Lake Buena Vista Resort Village & Spa](https://images.trvl-media.com/lodging/2000000/1360000/1350900/1350864/16b6b8e7_y.jpg) ### Lake Buena Vista Resort Village & Spa 10/10 Excellent "Great place to stay!" [](https://expedia.ca/Orlando-Hotels-Lake-Buena-Vista-Resort-Village-Spa.h1350864.Hotel-Information) ![DoubleTree by Hilton at the Entrance to Universal Orlando](https://images.trvl-media.com/lodging/1000000/10000/5400/5398/4997b5df_y.jpg) ### DoubleTree by Hilton at the Entrance to Universal Orlando 10/10 Excellent "Clean, beautifully decorated and amazing staff! Great food!" [](https://expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-At-The-Entrance-To-Universal-Orlando.h5398.Hotel-Information) ![DoubleTree by Hilton Hotel Orlando at SeaWorld](https://images.trvl-media.com/lodging/1000000/20000/18900/18874/69019073_y.jpg) ### DoubleTree by Hilton Hotel Orlando at SeaWorld 10/10 Excellent "good" [](https://expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Hotel-Orlando-At-SeaWorld.h18874.Hotel-Information) ![Avanti International Resort](https://images.trvl-media.com/lodging/1000000/10000/3900/3832/b0f81967_y.jpg) ### Avanti International Resort 10/10 Excellent "yes" [](https://expedia.ca/Orlando-Hotels-Avanti-International-Resort.h3832.Hotel-Information) ![Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando](https://images.trvl-media.com/lodging/1000000/30000/23200/23110/ade3b60d_y.jpg) ### Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando 10/10 Excellent "Perfect" [](https://expedia.ca/Orlando-Hotels-Sheraton-Vistana-Resort-Villas.h23110.Hotel-Information) ![DoubleTree by Hilton Hotel Orlando Downtown](https://images.trvl-media.com/lodging/1000000/20000/10600/10565/cdfd5651_y.jpg) ### DoubleTree by Hilton Hotel Orlando Downtown 10/10 Excellent "Excellent hotel " [](https://expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Orlando-Downtown.h10565.Hotel-Information) ![Walt Disney World Dolphin](https://images.trvl-media.com/lodging/1000000/20000/12800/12710/a6b6c49c_y.jpg) ### Walt Disney World Dolphin 10/10 Excellent "Convenience to Epcot and Hollywood Studios will bring me back. " [](https://expedia.ca/Orlando-Hotels-Walt-Disney-World-Dolphin.h12710.Hotel-Information) ## Frequently asked questions ### What are the best 4-star hotels in Lake Nona Medical City? ### How much does it cost to stay in a 4-star hotel in Lake Nona Medical City? > - Search for the lowest price from CA $670 ### What's the difference between 5-star and 4-star hotels in Lake Nona Medical City? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [1 Star Hotels in Carver Shores ](https://www.expedia.ca/1Star-Carver-Shores-Orlando-Hotels.s10-n553248635976478799-0.Travel-Guide-Filter-Hotels) - [1 Star Hotels in Orlando ](https://www.expedia.ca/1Star-Orlando-Hotels.s10-0-d178294.Travel-Guide-Filter-Hotels) - [1 Star Hotels in Southwest Orlando ](https://www.expedia.ca/1Star-Southwest-Orlando-Hotels.s10-0-d553248635976470816.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Buena Ventura Lakes ](https://www.expedia.ca/2Star-Buena-Ventura-Lakes-Orlando-Hotels.s20-n6360408-0.Travel-Guide-Filter-Hotels) - 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