Title: 3 Stars Hotels in Medical Center District, San Antonio from CA $85 - Find Cheap Medical Center District Hotels With 3 Stars | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/8f3b15d1d7d73e712570109708f4e829.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Linda Cronan # 3 Stars Hotels in Medical Center District, San Antonio from CA $85 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical Center District 3 Star Hotels Tonight [Oct 20 - Oct 21](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-20&endDate=2025-10-21&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 21 - Oct 22](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-21&endDate=2025-10-22&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical Center District 3 Star Hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/07244ab2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/c06966e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/02446d01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza Downtown San Antonio 8.4/10 Very good (1802) "Clean and Comfortable room with good breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JOSEPH CA $122 CA $144 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/a3dd07e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shopping mall](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/63a37f35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner served; American cuisine, alfresco dining ](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/7c60c418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/2e90fb1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crockett Hotel Downtown San Antonio 9.0/10 Wonderful (2473) "Fabulous place to stay, highly recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa CA $126 CA $149 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/40c220b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed (2 Rooms, Jetted Tub, Terrace)](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/89c8fbb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/57194f46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel San Antonio Riverwalk Downtown San Antonio 9.4/10 Exceptional (3880) "We had an awesome stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angel CA $168 CA $199 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/8fcc83d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/bf8ffe69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/9337ea37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW Medical Center District 8.6/10 Excellent (3033) "We always enjoy our stay at this hotel. The staff are always friendly, premises clean, and breakfast is great! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Armand CA $125 CA $147 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/b4bcb4da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/ed18eebd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/f91ea4c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/defe38fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Antonio I-35 N at Toepperwein Live Oak 5.6/10 (1391) "Nice place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Truman CA $74 CA $85 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-By-Wyndham-San-Antonio-I-35-N-At-Toepperwein.h23493.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/ae1a8ff6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/578a3dd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and brunch served](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/de8007fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/54b84591.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Menger Hotel Downtown San Antonio 9.0/10 Wonderful (3495) "Beautiful hotel - great staff. Close to Riverwalk restaurants and bars and right on the plaza. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara CA $157 CA $186 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information) ![Water park](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/5058d5ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4657a7fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/bdb1061e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/afa62b6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Vacation Club at Wild Oak Ranch, San Antonio Far West Side 9.0/10 Wonderful (1141) "Great family friendly resort" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Teang CA $121 CA $201 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/544ec14c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 2 Double Beds, Non Smoking (Deluxe Family Suite)](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/eccadf60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/732bf58e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/e063f032.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk Downtown San Antonio 7.8/10 Good (3715) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marialuisa CA $100 CA $142 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) ![Pillowtop beds, in-room safe, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/9e3e8920.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/d3db9a5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/b25710dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/16d41ec1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark By Hilton San Antonio Northwest near Six Flags La Cantera District 7.8/10 Good (1677) "Great one night stay. The hotel was clean and quite. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria CA $83 CA $99 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/San-Antonio-Hotels-Quality-Inn-San-Antonio-Fiesta-At-Six-Flags.h41271.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/fda28f35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/f4467377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/e14eb0a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/e9c6a182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Downtown Downtown San Antonio 9.0/10 Wonderful (3086) "We loved our stay!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) ziba CA $105 CA $124 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Downtown.h421726.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/a85730af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/5f5807c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/507bc31c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/0b5b7b15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Antonio SeaWorld - Westover Hills Far West Side 8.6/10 Excellent (1031) "Will stay there again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elena De La CA $136 CA $161 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/San-Antonio-Hotels-Courtyard-By-Marriott-San-Antonio-SeaWorld-Westover-Hills.h2654325.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/053f15e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/0df91985.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 6:00 AM to 11:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/d3568343.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Antonio Marriott Northwest Medical Center Medical Center District 8.6/10 Excellent (1028) "Only stayed one night, but our room was very clean and comfortable! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dianne CA $125 CA $148 total includes taxes & fees Nov 14 - Nov 15 [](https://www.expedia.ca/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/29a15f17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/7305a30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/6e732dd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/9d9a265b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel San Antonio Airport Uptown 9.4/10 Exceptional (1877) "Clean room, nice outdoor pool and hot tub, Staff was very nice and helpful, Location was wonderful, would go again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fjona CA $132 CA $156 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Airport.h9037.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/bbc76004.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/fc3a378c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/a863da86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/4cdac407.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Airport Uptown 7.6/10 Good (2828) "Very convenient to shopping to food to downtown " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) alex CA $105 CA $125 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Airport.h809466.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/5fbb5d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/1eb6aedb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/2717104d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/c17e450c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites By Wyndham San Antonio At The Rim Forest Crest 9.2/10 Wonderful (688) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald CA $116 CA $135 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-At-The-Rim.h109052763.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/3000000/2520000/2514100/2514084/dbedad38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2520000/2514100/2514084/43f360ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![aloft, Room, 2 Queen Beds](https://images.trvl-media.com/lodging/3000000/2520000/2514100/2514084/5f0a1907.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2520000/2514100/2514084/5941a081.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aloft San Antonio Airport Shearer Hills - Ridgeview 8.6/10 Excellent (1019) "Enjoyed my stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Audrey CA $116 CA $137 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Antonio-Hotels-Aloft-San-Antonio-Airport.h2514084.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/dfb09e21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/f29fe4dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/f18ce883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/2c9364ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place San Antonio–North/Stone Oak Stone Oak 8.8/10 Excellent (1014) "Everything was great…if I come back, I’ll be staying there again 👍" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rafael CA $123 CA $146 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Place-San-AntonioNorthStone-Oak.h3411197.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/5f5ef28b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/02e74859.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/79a812b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/afcd335d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn San Antonio - Riverwalk by IHG Downtown San Antonio 8.4/10 Very good (1107) "Great room and breakfast and location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $156 CA $184 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/San-Antonio-Hotels-Holiday-Inn-San-Antonio-Riverwalk.h12642.Hotel-Information) ![Free continental breakfast on weekends](https://images.trvl-media.com/lodging/67000000/66160000/66150900/66150832/8b2b8505.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/67000000/66160000/66150900/66150832/d8d2331c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/67000000/66160000/66150900/66150832/18f2e499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast on weekends](https://images.trvl-media.com/lodging/67000000/66160000/66150900/66150832/f2890a24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB San Antonio 9.2/10 Wonderful (1121) "Clean rooms, friendly staff, great breakfast bar" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephanie CA $126 CA $147 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-SeaworldLAFB.h66150832.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/80fb914d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/4d828940.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/88117f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/510f50b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites San Antonio Riverwalk Downtown San Antonio 9.4/10 Exceptional (1686) "Great location and breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alexandra CA $168 CA $199 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Riverwalk.h415664.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F3Star-Medical-Center-District-San-Antonio-Hotels.s30-n553248635978913844-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F3Star-Medical-Center-District-San-Antonio-Hotels.s30-n553248635978913844-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 3-star hotels. See all 4-star hotels in Medical Center District. ![Hotel Valencia Riverwalk](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Valencia Riverwalk 150 E Houston St, San Antonio, TX CA $178 CA $248 total Oct 30 - Oct 31 includes taxes & fees 9.4/10 Exceptional! (2,068 reviews) [](https://expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information) ![Riverwalk Plaza](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Riverwalk Plaza 100 Villita Street, Dwyer/Main Plaza, San Antonio, TX CA $125 CA $148 total Oct 27 - Oct 28 includes taxes & fees 8/10 Very Good! (5,921 reviews) [](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![Hyatt Regency San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hyatt Regency San Antonio Riverwalk 123 Losoya St, San Antonio, TX CA $213 CA $302 total Nov 5 - Nov 6 includes taxes & fees 9/10 Wonderful! (1,847 reviews) [](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information) Still don't see what you're looking for? [See all properties in Medical Center District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F10%2F2025&endDate=22%2F10%2F2025®ionId=553248635978913844&star=30) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F10%2F2025&endDate=22%2F10%2F2025®ionId=553248635978913844&star=30&star=30&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F10%2F2025&endDate=22%2F10%2F2025®ionId=553248635978913844&star=30&star=30&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F10%2F2025&endDate=22%2F10%2F2025®ionId=553248635978913844&star=30&star=30&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F10%2F2025&endDate=22%2F10%2F2025®ionId=553248635978913844&star=30&star=30&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F10%2F2025&endDate=22%2F10%2F2025®ionId=553248635978913844&star=30&star=30&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Medical Center District Hotel Reviews ![Drury Plaza Hotel San Antonio Riverwalk](//images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435_y.jpg) ### Drury Plaza Hotel San Antonio Riverwalk 10/10 Excellent "Everything was pleasant. Will definitely be staying again." [](https://expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![Spark By Hilton San Antonio Northwest near Six Flags](//images.trvl-media.com/lodging/1000000/50000/41300/41271/9e3e8920_y.jpg) ### Spark By Hilton San Antonio Northwest near Six Flags 10/10 Excellent "Amazing so far " [](https://expedia.ca/San-Antonio-Hotels-Quality-Inn-San-Antonio-Fiesta-At-Six-Flags.h41271.Hotel-Information) ![Crockett Hotel](//images.trvl-media.com/lodging/1000000/10000/1600/1534/a3dd07e6_y.jpg) ### Crockett Hotel 10/10 Excellent "Fabulous place to stay, highly recommend " [](https://expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![Sonesta ES Suites San Antonio Downtown Alamo Plaza](//images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza 10/10 Excellent "Friendly and helpful staff. Walk to the Riverwalk and The Alamo. Excellent rooms. Hot breakfast (free).Spendy parking. " [](https://expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW](//images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW 10/10 Excellent "Quiet and clean with friendly staff." [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) ![Courtyard by Marriott Medical Center San Antonio](//images.trvl-media.com/lodging/1000000/20000/12600/12556/2045bf85_y.jpg) ### Courtyard by Marriott Medical Center San Antonio 10/10 Excellent "We loved the clean room, friendly staff, and nice sitting areas. " [](https://expedia.ca/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information) ## Frequently asked questions ### What are the best 3-star hotels in Medical Centre District? > [Courtyard by Marriott Medical Centre San Antonio](https://www.expedia.ca/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information) gets great reviews from our travellers for its affordable rates, comfort and lots more. You'll find this 3-star hotel in or around Medical Centre District. ### How much does it cost to stay in a 3-star hotel in Medical Centre District? > Uncover the perfect trifecta of affordability, quality and comfort at a 3-star hotel in Medical Centre District with Expedia's filter tools. Enter your vacation dates and then fine-tune your search based on what you want to spend per night. > > > > - Search for the lowest price per night right now from CA $148 ### What is the difference between a 4-star and 3-star hotel in Medical Centre District? > The big difference between a 3- and 4-star hotel in Medical Centre District is the level of service and access to creature comforts. 3-star hotels are typically more pocket-friendly and offer the conveniences and services you need to be comfortable, such as a gym, WiFi and breakfast. 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[Hotels near Monster Mini Golf](https://www.expedia.ca/Monster-Mini-Golf-Hotels.0-l553248621532643386-0.Travel-Guide-Filter-Hotels) - [Hotels with smoking rooms in North Central](https://www.expedia.ca/North-Central-San-Antonio-Hotels-Hotels-With-Smoking-Rooms.0-n3000663370-0-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - [North Central Hotels](https://www.expedia.ca/North-Central-San-Antonio-Hotels.0-n3000663370-0.Travel-Guide-Filter-Hotels) - [Hotels near North Star Mall](https://www.expedia.ca/North-Star-Mall-Hotels.0-l502628-0.Travel-Guide-Filter-Hotels) - [Golf Hotels in Northwest Los Angeles Heights](https://www.expedia.ca/Northwest-Los-Angeles-Heights-San-Antonio-Hotels-Golf-Hotel.0-n553248635976480994-0-tGolfHotel.Travel-Guide-Filter-Hotels) - [Hotels with Free Parking in Northwest Los Angeles Heights](https://www.expedia.ca/Northwest-Los-Angeles-Heights-San-Antonio-Hotels-Hotels-With-Free-Parking.0-n553248635976480994-0-tHotelswithFreeParking.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Northwest Los Angeles Heights](https://www.expedia.ca/Northwest-Los-Angeles-Heights-San-Antonio-Hotels-Hotels-With-Indoor-Pool.0-n553248635976480994-0-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Northwest Los Angeles Heights](https://www.expedia.ca/Northwest-Los-Angeles-Heights-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976480994-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Cheap-Hotels.0-n887264728595001344-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Family-Hotel.0-n887264728595001344-0-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Hotels-With-Free-Airport-Shuttle.0-n887264728595001344-0-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Hotels-With-Kitchenettes.0-n887264728595001344-0-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n887264728595001344-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Spa-Hotel.0-n887264728595001344-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Hotels near Oak Hills Country Club](https://www.expedia.ca/Oak-Hills-Country-Club-Hotels.0-l553248621532643653-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Boutique-Hotel.0-n6230858-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Hotel-With-Early-Check-In.0-n6230858-0-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Romantic-Hotel.0-n6230858-0-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Spa-Hotel.0-n6230858-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Waterpark-Hotels.0-n6230858-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Olmos Park Terrace Hotels](https://www.expedia.ca/Olmos-Park-Terrace-San-Antonio-Hotels.0-n553248635976469841-0.Travel-Guide-Filter-Hotels) - [Hotels near Phil Hardberger Park](https://www.expedia.ca/Phil-Hardberger-Park-Hotels.0-l553248621532643389-0.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Prospect Hill](https://www.expedia.ca/Prospect-Hill-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976387013-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [San Antonio Hotels](https://www.expedia.ca/San-Antonio-Hotels.d178303.Travel-Guide-Hotels) - [Shavano Park Hotels](https://www.expedia.ca/Shavano-Park-San-Antonio-Hotels.0-n6004947-0.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Shearer Hills - Ridgeview](https://www.expedia.ca/Shearer-Hills-Ridgeview-San-Antonio-Hotels-Adults-Only-Resorts.0-n553248635976471907-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Hotels near South Texas Medical Center](https://www.expedia.ca/South-Texas-Medical-Center-Hotels.0-l6193120-0.Travel-Guide-Filter-Hotels) - [Hotels near St. Mary's University](https://www.expedia.ca/St-Marys-University-Hotels.0-l502632-0.Travel-Guide-Filter-Hotels) - [Hotels near USAA Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Hotels.0-l553248621593511346-0.Travel-Guide-Filter-Hotels) - [Hotels near University of Texas Health and Science Center at San Antonio](https://www.expedia.ca/University-Of-Texas-Health-And-Science-Center-At-San-Antonio-Hotels.0-l6191585-0.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Vance Jackson](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels-All-Inclusive-Hotel.0-n553248635976480877-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Vance Jackson Hotels](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels.0-n553248635976480877-0.Travel-Guide-Filter-Hotels) - [Vista Del Norte Hotels](https://www.expedia.ca/Vista-Del-Norte-San-Antonio-Hotels.0-n553248635976474068-0.Travel-Guide-Filter-Hotels) - [Hotels near Wonderland of the Americas Mall](https://www.expedia.ca/Wonderland-Of-The-Americas-Mall-Hotels.0-l6127197-0.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Woodlawn Lake](https://www.expedia.ca/Woodlawn-Lake-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976476298-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels near Woodlawn Theater](https://www.expedia.ca/Woodlawn-Theater-Hotels.0-l6083191-0.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Woodridge](https://www.expedia.ca/Woodridge-San-Antonio-Hotels-Best-Western.0-n553248635976386203-0--bBestWestern.Travel-Guide-Filter-Hotels) - [Flights from Vancouver (YVR) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yvr/sat/vancouver-to-san-antonio) - [Flights from Calgary (YYC) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyc/sat/calgary-to-san-antonio) - [Flights from Toronto (YYZ) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyz/sat/toronto-to-san-antonio) - [North Star Mall](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction) - [Visit Balcones Heights](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368) - [Visit Castle Hills](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679) - [Visit Leon Valley](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419) - [Visit Oakland Estates](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858) - [Usaa Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction) - [Car rentals near Shavano Park](https://www.expedia.ca/Car-Rentals-In-Shavano-Park.d6004947.Car-Rental-Guide) - [Car rentals near USAA Corporate Office Headquarters](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide) - 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