Title: 3 Stars Hotels in Medical Center District, San Antonio from CA $78 - Find Cheap Medical Center District Hotels With 3 Stars | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![River walk in San Antonio](https://images.trvl-media.com/place/553248635978913844/ef5a7faf-f6d9-4f7e-b325-ac477c5ad14d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 3 Stars Hotels in Medical Center District, San Antonio from CA $78 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical Center District 3 Star Hotels Tonight [Dec 6 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-06&endDate=2025-12-07&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 7 - Dec 8](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-07&endDate=2025-12-08&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical Center District 3 Star Hotels ![Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/a3dd07e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner served; American cuisine, alfresco dining ](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/7c60c418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/6841f291.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/2e90fb1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crockett Hotel Downtown San Antonio 9.0/10 Wonderful (2500) "Fabulous place to stay, highly recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa CA $116 CA $137 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/544ec14c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/e063f032.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/732bf58e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 2 Double Beds, Non Smoking (Deluxe Family Suite)](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/eccadf60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk Downtown San Antonio 7.8/10 Good (3757) "The room is clean and staff is friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $99 CA $142 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/40c220b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/f061a976.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/57194f46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel San Antonio Riverwalk Downtown San Antonio 9.4/10 Exceptional (4083) "Very nice stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anthony CA $166 CA $196 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/8fcc83d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/ded9f09f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/bf8ffe69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW Medical Center District 8.4/10 Very good (3099) "quite place with good breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Juan CA $123 CA $145 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) ![Pillowtop beds, in-room safe, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/9e3e8920.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/16d41ec1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/b25710dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/a9438006.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark By Hilton San Antonio Northwest near Six Flags La Cantera District 7.8/10 Good (1777) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Katherine CA $81 CA $96 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-Quality-Inn-San-Antonio-Fiesta-At-Six-Flags.h41271.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/ae1a8ff6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and brunch served](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/de8007fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/dd0efe60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/578a3dd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Menger Hotel Downtown San Antonio 9.0/10 Wonderful (3556) "Historic and classy, and you can beat the location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Warren CA $130 CA $153 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/fda28f35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/7a766aa4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/e14eb0a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/f4467377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Downtown Downtown San Antonio 9.0/10 Wonderful (3114) "Very clean hotel and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) antonio CA $110 CA $130 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Downtown.h421726.Hotel-Information) ![Water park](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/5058d5ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4657a7fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/afa62b6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/72554b53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Vacation Club at Wild Oak Ranch, San Antonio Far West Side 9.0/10 Wonderful (1267) "Awesome place to stay at " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diego CA $98 CA $173 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/02446d01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/07244ab2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/w3836h2560x4y4-c1e2db94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza Downtown San Antonio 8.4/10 Very good (1876) "Staff and location! Also the room was very comfortable! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose Luis CA $120 CA $142 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/5fbb5d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/41c45dbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/1eb6aedb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/2717104d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites By Wyndham San Antonio At The Rim Forest Crest 9.2/10 Wonderful (798) "Great place to stay!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stacy CA $116 CA $136 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-At-The-Rim.h109052763.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/4000000/3260000/3257800/3257765/ed932688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/4000000/3260000/3257800/3257765/10d03908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/4000000/3260000/3257800/3257765/58c5cadb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch LCD TV with premium channels, TV, pay movies](https://images.trvl-media.com/lodging/4000000/3260000/3257800/3257765/6ab1f7a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites San Antonio Riverwalk-Downtown Downtown San Antonio 9.0/10 Wonderful (1333) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maricella CA $176 CA $209 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-Embassy-Suites-San-Antonio-Riverwalk-Downtown.h3257765.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/21812fda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/fe25d6a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/32971f60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/b779d999.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Airport Uptown 7.6/10 Good (2800) "Courteous staff , clean bed & bathrooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ralph CA $104 CA $123 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Airport.h809466.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/5f5ef28b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/02e74859.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/79a812b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/afcd335d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn San Antonio - Riverwalk by IHG Downtown San Antonio 8.4/10 Very good (1164) "great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Enrique CA $138 CA $163 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Holiday-Inn-San-Antonio-Riverwalk.h12642.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/a85730af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/0b5b7b15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/507bc31c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/1069616f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Antonio SeaWorld - Westover Hills Far West Side 8.6/10 Excellent (1081) "good hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Deborah CA $128 CA $152 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-Courtyard-By-Marriott-San-Antonio-SeaWorld-Westover-Hills.h2654325.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/dfb09e21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/050c037f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/f18ce883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/f29fe4dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place San Antonio–North/Stone Oak Stone Oak 8.8/10 Excellent (1001) "Great Stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rachel CA $137 CA $162 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Place-San-AntonioNorthStone-Oak.h3411197.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/053f15e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/0df91985.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/243881ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Antonio Marriott Northwest Medical Center Medical Center District 8.6/10 Excellent (1001) "The room is clean and the hotel staff are all nice including the staff from the restourant" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Frank Charles CA $123 CA $146 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/80fb914d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/88117f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/6691d47c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/510f50b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites San Antonio Riverwalk Downtown San Antonio 9.4/10 Exceptional (1746) "location and value are really great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael D. CA $166 CA $196 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Riverwalk.h415664.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/29a15f17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/9d9a265b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/c6155f5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/7305a30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel San Antonio Airport Uptown 9.4/10 Exceptional (1924) "Great hotel in the center of everything. Loved all the food benefits and felt safe, nice parking too!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley CA $124 CA $147 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Airport.h9037.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/6300/6262/229a4017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 10 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/6300/6262/4cd2c3f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/6300/6262/0d27ff49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room](https://images.trvl-media.com/lodging/1000000/10000/6300/6262/6b2c6c5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Market Square Downtown San Antonio 4.0/10 (656) "Some of the hotel rooms had padlocks and there was a cop investigating a crime on the property. This place should not even be on the list, Expedia do better." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Victoria CA $67 CA $78 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/San-Antonio-Hotels-The-Inn-At-Market-Square.h6262.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/b4bcb4da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/a0a258c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/f91ea4c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/defe38fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Antonio I-35 N at Toepperwein Live Oak 5.6/10 (1429) "Very good " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis CA $73 CA $84 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-By-Wyndham-San-Antonio-I-35-N-At-Toepperwein.h23493.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F3Star-Medical-Center-District-San-Antonio-Hotels.s30-n553248635978913844-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F3Star-Medical-Center-District-San-Antonio-Hotels.s30-n553248635978913844-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 3-star hotels. See all 4-star hotels in Medical Center District. ![Hotel Valencia Riverwalk](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Valencia Riverwalk 150 E Houston St San Antonio TX CA $128 CA $191 total Dec 25 - Dec 26 includes taxes & fees 9.4/10 Exceptional! (2,208 reviews) [](https://expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information) ![Riverwalk Plaza](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Riverwalk Plaza 100 Villita Street San Antonio TX CA $123 CA $146 total Dec 7 - Dec 8 includes taxes & fees 8/10 Very Good! (6,152 reviews) [](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![The Westin Riverwalk, San Antonio](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Westin Riverwalk, San Antonio 420 W Market St San Antonio TX CA $215 CA $256 total Dec 22 - Dec 23 includes taxes & fees 8.8/10 Excellent! (1,420 reviews) [](https://expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information) Still don't see what you're looking for? [See all properties in Medical Center District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F12%2F2025&endDate=08%2F12%2F2025®ionId=553248635978913844&star=30) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F12%2F2025&endDate=08%2F12%2F2025®ionId=553248635978913844&star=30&star=30&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F12%2F2025&endDate=08%2F12%2F2025®ionId=553248635978913844&star=30&star=30&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F12%2F2025&endDate=08%2F12%2F2025®ionId=553248635978913844&star=30&star=30&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F12%2F2025&endDate=08%2F12%2F2025®ionId=553248635978913844&star=30&star=30&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F12%2F2025&endDate=08%2F12%2F2025®ionId=553248635978913844&star=30&star=30&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Medical Center District Hotel Reviews ![Sonesta ES Suites San Antonio Downtown Alamo Plaza](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza 10/10 Excellent "Overall it was a great stay" [](https://expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![Drury Plaza Hotel San Antonio Riverwalk](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435_y.jpg) ### Drury Plaza Hotel San Antonio Riverwalk 10/10 Excellent "Great clean hotel" [](https://expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW 10/10 Excellent "Clean rooms" [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/544ec14c_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk 10/10 Excellent "Loved it, clean nice just a walk away to riverwalk" [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Downtown](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/fda28f35_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Downtown 10/10 Excellent "Great staff, with quick checkin and checkout. Free open lot parking onsite. Surprisingly good hot breakfast. short walk to marketplace, Riverwalk, other attractions." [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Downtown.h421726.Hotel-Information) ![Crockett Hotel](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/a3dd07e6_y.jpg) ### Crockett Hotel 10/10 Excellent "Really clean rooms!" [](https://expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![Courtyard by Marriott Medical Center San Antonio](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/2045bf85_y.jpg) ### Courtyard by Marriott Medical Center San Antonio 10/10 Excellent "Room was clean, staff was very friendly!!" [](https://expedia.ca/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information) ## Frequently asked questions ### What are the best 3-star hotels in Medical Centre District? ### How much does it cost to stay in a 3-star hotel in Medical Centre District? > - Search for the lowest price per night right now from CA $146 ### What is the difference between a 4-star and 3-star hotel in Medical Centre District? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [1 Star Hotels in Fredericksburg ](https://www.expedia.ca/1Star-Fredericksburg-Hotels.s10-0-d6059096.Travel-Guide-Filter-Hotels) - [1 Star Hotels in Southside ](https://www.expedia.ca/1Star-Southside-Hotels.s10-0-d553248635939576783.Travel-Guide-Filter-Hotels) - [2 Star Hotels in North San Antonio - SAT ](https://www.expedia.ca/2Star-North-San-Antonio-SAT-Hotels.s20-0-d553248633938962547.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Southside ](https://www.expedia.ca/2Star-Southside-Hotels.s20-0-d553248635939576783.Travel-Guide-Filter-Hotels) - 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