Title: 3 Stars Hotels in Medical Center District, San Antonio from CA $77 - Find Cheap Medical Center District Hotels With 3 Stars | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical Center District 3 Star Hotels Tonight [Feb 6 - Feb 7](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 7 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2026-02-07&endDate=2026-02-08&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=30&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Medical Center District 3-star hotels ![Reception](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/2e90fb1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/a296bfd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/4ab60c37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shopping mall](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/63a37f35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crockett Hotel [](https://www.expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) Downtown San Antonio 8.8/10 Excellent (2,550 reviews) "Clearn room, excellent staff, superb location, walkable to all the major sites." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald CA $128 CA $151 total includes taxes & fees Feb 18 - Feb 19 [](https://www.expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/9feb5dde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/544ec14c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 2 Double Beds, Non Smoking (Deluxe Family Suite)](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/eccadf60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/2b355eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) Downtown San Antonio 7.8/10 Good (3,861 reviews) "very nice and clean rooms close to all the good attractions " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) nancy CA $97 CA $142 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/40c220b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/43045ac3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/b84caf37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/f061a976.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel San Antonio Riverwalk [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) Downtown San Antonio 9.4/10 Exceptional (4,260 reviews) "This was a great stay, very convenient and excellent food" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alyssa CA $165 CA $194 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/3b4d6808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/dd105881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/8fcc83d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/ded9f09f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) Medical Center District 8.4/10 Very good (3,194 reviews) "Great stay with nice breakfast and clean rooms " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leah CA $121 CA $143 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/8db3c38d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/b607efdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/9e3e8920.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/16d41ec1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark By Hilton San Antonio Northwest near Six Flags [](https://www.expedia.ca/San-Antonio-Hotels-Quality-Inn-San-Antonio-Fiesta-At-Six-Flags.h41271.Hotel-Information) La Cantera District 8.0/10 Very good (1,943 reviews) "Clean rooms, good location, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) APRIL CA $80 CA $97 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/San-Antonio-Hotels-Quality-Inn-San-Antonio-Fiesta-At-Six-Flags.h41271.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/ae1a8ff6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/04834ef7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/0a592140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/578a3dd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Menger Hotel [](https://www.expedia.ca/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information) Downtown San Antonio 9.0/10 Wonderful (3,778 reviews) "Loved the stay here. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $148 CA $175 total includes taxes & fees Feb 16 - Feb 17 [](https://www.expedia.ca/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/7a766aa4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/c2a1970a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/fda28f35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/3a901626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Downtown [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Downtown.h421726.Hotel-Information) Downtown San Antonio 9.0/10 Wonderful (3,238 reviews) "Nice clean spacious rooms, awesome location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin CA $108 CA $127 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Downtown.h421726.Hotel-Information) ![Fireplace](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4657a7fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/afa62b6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4f4dbae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/72554b53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Vacation Club at Wild Oak Ranch, San Antonio [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information) Far West Side 9.0/10 Wonderful (1,429 reviews) "Great room and amenities, gorgeous property " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) jason CA $104 CA $179 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/2727a411.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/c06966e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/7e4ced65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza [](https://www.expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) Downtown San Antonio 8.4/10 Very good (1,992 reviews) "I really liked and enjoyed my stay at this hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angelica CA $141 CA $166 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/5fbb5d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/2717104d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/1eb6aedb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/110000000/109060000/109052800/109052763/c17e450c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites By Wyndham San Antonio At The Rim [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-At-The-Rim.h109052763.Hotel-Information) Forest Crest 9.2/10 Wonderful (917 reviews) "Wonderful place to stay. Room’s clean and the staff were professional and kind. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lydia CA $115 CA $135 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-At-The-Rim.h109052763.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/4000000/3260000/3257800/3257765/87af4d7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/4000000/3260000/3257800/3257765/6ae8ab15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3260000/3257800/3257765/4d2f5fb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/4000000/3260000/3257800/3257765/w5754h3835x5y5-ac2e46af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites San Antonio Riverwalk-Downtown [](https://www.expedia.ca/San-Antonio-Hotels-Embassy-Suites-San-Antonio-Riverwalk-Downtown.h3257765.Hotel-Information) Downtown San Antonio 9.0/10 Wonderful (1,388 reviews) "Excellent location, breakfast and rooms. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tamara CA $226 CA $271 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Antonio-Hotels-Embassy-Suites-San-Antonio-Riverwalk-Downtown.h3257765.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/b779d999.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/9d9102db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/7109ce40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/810000/809500/809466/1fd52d64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Airport [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Airport.h809466.Hotel-Information) Uptown 7.6/10 Good (2,795 reviews) "Great hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kirtan CA $103 CA $122 total includes taxes & fees Feb 18 - Feb 19 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Airport.h809466.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/5f5ef28b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/3eeff15f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/480db468.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/da668eda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn San Antonio - Riverwalk by IHG [](https://www.expedia.ca/San-Antonio-Hotels-Holiday-Inn-San-Antonio-Riverwalk.h12642.Hotel-Information) Downtown San Antonio 8.4/10 Very good (1,230 reviews) "Clean room, great breakfast, convenient location for walking around downtown and the riverwalk." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dillon CA $133 CA $157 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/San-Antonio-Hotels-Holiday-Inn-San-Antonio-Riverwalk.h12642.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/80ba06e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/507bc31c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/47a0500c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654325/30c8659d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Antonio SeaWorld - Westover Hills [](https://www.expedia.ca/San-Antonio-Hotels-Courtyard-By-Marriott-San-Antonio-SeaWorld-Westover-Hills.h2654325.Hotel-Information) Far West Side 8.6/10 Excellent (1,128 reviews) "the room was very clean and the staff was very friendly. Its was convenient to Seaworld and shopping destinations." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evelyn CA $127 CA $151 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/San-Antonio-Hotels-Courtyard-By-Marriott-San-Antonio-SeaWorld-Westover-Hills.h2654325.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/f29fe4dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/0c99fd59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/dfb09e21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3420000/3411200/3411197/050c037f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place San Antonio–North/Stone Oak [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Place-San-AntonioNorthStone-Oak.h3411197.Hotel-Information) Stone Oak 8.8/10 Excellent (1,002 reviews) "Room is clean, comfy bed, friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leslie CA $136 CA $160 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Place-San-AntonioNorthStone-Oak.h3411197.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/243881ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/e0b99e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/004315aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Antonio Marriott Northwest Medical Center [](https://www.expedia.ca/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information) Medical Center District 8.6/10 Excellent (1,003 reviews) "Courteous staff, clean room, safe location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Danica CA $138 CA $164 total includes taxes & fees Feb 28 - Mar 1 [](https://www.expedia.ca/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/80fb914d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/11998c35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/63eae952.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/420000/415700/415664/d6e9a3d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites San Antonio Riverwalk [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Riverwalk.h415664.Hotel-Information) Downtown San Antonio 9.4/10 Exceptional (1,804 reviews) "Friendly staff, free breakfast was excellent, very clean!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria CA $164 CA $194 total includes taxes & fees Feb 10 - Feb 11 [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Riverwalk.h415664.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/6e732dd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/636e76f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/9d9a265b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/10000/9100/9037/c6155f5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel San Antonio Airport [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Airport.h9037.Hotel-Information) Uptown 9.4/10 Exceptional (1,983 reviews) "Excellent customer service, very nice, clean and decent place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Manolo CA $123 CA $146 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Airport.h9037.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/6300/6262/229a4017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/6300/6262/37eecd3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/6300/6262/0d27ff49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/1000000/10000/6300/6262/2a65c200.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Market Square [](https://www.expedia.ca/San-Antonio-Hotels-The-Inn-At-Market-Square.h6262.Hotel-Information) Downtown San Antonio 4.0/10 (659 reviews) "Some of the hotel rooms had padlocks and there was a cop investigating a crime on the property. This place should not even be on the list, Expedia do better." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Victoria CA $66 CA $77 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/San-Antonio-Hotels-The-Inn-At-Market-Square.h6262.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/b4bcb4da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/ad1c8261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, Multiple Beds, Non Smoking (Deluxe Family Room)](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/7c5c9c17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/23500/23493/a0a258c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Antonio I-35 N at Toepperwein [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-By-Wyndham-San-Antonio-I-35-N-At-Toepperwein.h23493.Hotel-Information) Live Oak 5.6/10 (1,450 reviews) "Clean room service great area " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen CA $73 CA $83 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-By-Wyndham-San-Antonio-I-35-N-At-Toepperwein.h23493.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F3Star-Medical-Center-District-San-Antonio-Hotels.s30-n553248635978913844-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F3Star-Medical-Center-District-San-Antonio-Hotels.s30-n553248635978913844-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 3-star hotels. See all 4-star hotels in Medical Center District. ![Hotel Valencia Riverwalk](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Valencia Riverwalk 150 E Houston St San Antonio TX CA $181 CA $253 total Feb 22 - Feb 23 includes taxes & fees 9.2/10 Wonderful! (2,433 reviews) [](https://expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information) ![Riverwalk Plaza](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Riverwalk Plaza 100 Villita Street San Antonio TX CA $122 CA $144 total Feb 8 - Feb 9 includes taxes & fees 8/10 Very Good! (6,341 reviews) [](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![The Westin Riverwalk, San Antonio](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Westin Riverwalk, San Antonio 420 W Market St San Antonio TX CA $248 CA $295 total Feb 22 - Feb 23 includes taxes & fees 8.8/10 Excellent! (1,495 reviews) [](https://expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information) Still don't see what you're looking for? [See all properties in Medical Center District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F02%2F2026&endDate=08%2F02%2F2026®ionId=553248635978913844&star=30) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F02%2F2026&endDate=08%2F02%2F2026®ionId=553248635978913844&star=30&star=30&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F02%2F2026&endDate=08%2F02%2F2026®ionId=553248635978913844&star=30&star=30&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F02%2F2026&endDate=08%2F02%2F2026®ionId=553248635978913844&star=30&star=30&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F02%2F2026&endDate=08%2F02%2F2026®ionId=553248635978913844&star=30&star=30&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=07%2F02%2F2026&endDate=08%2F02%2F2026®ionId=553248635978913844&star=30&star=30&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Medical Center District Hotel Reviews ![Drury Plaza Hotel San Antonio Riverwalk](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435_y.jpg) ### Drury Plaza Hotel San Antonio Riverwalk 10/10 Excellent "Our stay at Drury Plaza was outstanding. Front desk, housekeeping, and restaurant staff were all amazing. Room was clean and roomy, hotel itself is in a historic building that is beautiful. Walkable to most of the downtown locations. Great stay! " [](https://expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Downtown](https://images.trvl-media.com/lodging/1000000/430000/421800/421726/fda28f35_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Downtown 10/10 Excellent "Nice clean spacious rooms, awesome location " [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Downtown.h421726.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW 10/10 Excellent "Everything was done right, at a very reasonable price! Very good value for the money." [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) ![Crockett Hotel](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/a3dd07e6_y.jpg) ### Crockett Hotel 10/10 Excellent "Everything clean and all staff were friendly " [](https://expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![Sonesta ES Suites San Antonio Downtown Alamo Plaza](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza 10/10 Excellent "Perfect for. Short stay near the Riverwalk." [](https://expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![Holiday Inn San Antonio - Riverwalk by IHG](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/5f5ef28b_y.jpg) ### Holiday Inn San Antonio - Riverwalk by IHG 10/10 Excellent "Everything was great!" [](https://expedia.ca/San-Antonio-Hotels-Holiday-Inn-San-Antonio-Riverwalk.h12642.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/544ec14c_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk 10/10 Excellent "Room was clean and staff was friendly!" [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) ## Frequently asked questions ### What are the best 3-star hotels in Medical Centre District? ### How much does it cost to stay in a 3-star hotel in Medical Centre District? > - Search for the lowest price per night right now from CA $144 ### What is the difference between a 4-star and 3-star hotel in Medical Centre District? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [1 Star Hotels in Fredericksburg ](https://www.expedia.ca/1Star-Fredericksburg-Hotels.s10-0-d6059096.Travel-Guide-Filter-Hotels) - [1 Star Hotels in Southside ](https://www.expedia.ca/1Star-Southside-Hotels.s10-0-d553248635939576783.Travel-Guide-Filter-Hotels) - [2 Star Hotels in North San Antonio - SAT ](https://www.expedia.ca/2Star-North-San-Antonio-SAT-Hotels.s20-0-d553248633938962547.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Southside ](https://www.expedia.ca/2Star-Southside-Hotels.s20-0-d553248635939576783.Travel-Guide-Filter-Hotels) - 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