Title: 2 Stars Hotels in Medical Center District, San Antonio from CA $57 - Find Cheap Medical Center District Hotels With 2 Stars | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![SanAntonio_SouthTexasMedicalCenter_6193120_01](https://images.trvl-media.com/place/6193120/6208bc73-d0ab-4fda-b1af-d2c1bae086ed.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 2 Stars Hotels in Medical Center District, San Antonio from CA $57 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical Center District 2 Star Hotels Tonight [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-12&endDate=2025-12-13&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-13&endDate=2025-12-14&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Medical Center District 2-star hotels ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489262/70cfe6ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489262/4555b399.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489262/ebd47dc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489262/1d92ce2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites San Antonio-Airport [](https://www.expedia.ca/San-Antonio-Hotels-Hampton-Inn-Suites-San-Antonio-Airport.h1489262.Hotel-Information) Uptown 8.4/10 Very good (1765) "Very convenient to the airport!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $109 CA $132 total includes taxes & fees Jan 7 - Jan 8, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Hampton-Inn-Suites-San-Antonio-Airport.h1489262.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/13100/13100/5c8788d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/13100/13100/dcf3846c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/13100/13100/0a2b8ff1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/13100/13100/fa794f26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn San Antonio-Downtown (River Walk) [](https://www.expedia.ca/San-Antonio-Hotels-Hampton-Inn-San-Antonio-Downtown.h13100.Hotel-Information) Downtown San Antonio 8.4/10 Very good (2413) "Great staff, close to the River Walk and the San Antonio Convention Center." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yunwei CA $102 CA $121 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Hampton-Inn-San-Antonio-Downtown.h13100.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/70000/64200/64197/a863f3ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/70000/64200/64197/c5b5a268.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/70000/64200/64197/b3784716.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/70000/64200/64197/a5564a39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn PLUS+ San Antonio Downtown - Riverwalk [](https://www.expedia.ca/San-Antonio-Hotels-Red-Roof-Inn-PLUS-San-Antonio-Downtown-Riverwalk.h64197.Hotel-Information) Downtown San Antonio 7.0/10 Good (1764) "Room was clean and staff were very courteous " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy CA $81 CA $95 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/San-Antonio-Hotels-Red-Roof-Inn-PLUS-San-Antonio-Downtown-Riverwalk.h64197.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/20000000/19430000/19423600/19423558/76db1798.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/19430000/19423600/19423558/9b7efdcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/20000000/19430000/19423600/19423558/b563d648.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/20000000/19430000/19423600/19423558/86418667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites San Antonio Lackland AFB SeaWorld [](https://www.expedia.ca/San-Antonio-Hotels-Hampton-Inn-Suites-San-Antonio-Lackland-AFB-SeaWorld.h19423558.Hotel-Information) Far West Side 8.8/10 Excellent (1166) "Great location for us visiting Lackland AFB. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $120 CA $145 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Hampton-Inn-Suites-San-Antonio-Lackland-AFB-SeaWorld.h19423558.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/41300/41233/w3837h2560x3y4-03f641a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor spa tub](https://images.trvl-media.com/lodging/1000000/50000/41300/41233/7b5019c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41300/41233/w3837h2559x3y3-9d876780.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/50000/41300/41233/w3837h2563x3y0-b005f770.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Alamo Suites [](https://www.expedia.ca/San-Antonio-Hotels-Best-Western-Alamo-Suites.h41233.Hotel-Information) Downtown San Antonio 8.6/10 Excellent (1000) "Good stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adriana CA $103 CA $121 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Antonio-Hotels-Best-Western-Alamo-Suites.h41233.Hotel-Information) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/50000/40500/40463/fa147598.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/50000/40500/40463/c2d99abe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40500/40463/8b27aca8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/40500/40463/7b2bf396.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn San Antonio - Airport [](https://www.expedia.ca/San-Antonio-Hotels-Red-Roof-Inn-San-Antonio-Airport.h40463.Hotel-Information) Uptown 8.2/10 Very good (1123) "Staff was so friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shqiprim CA $63 CA $75 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Red-Roof-Inn-San-Antonio-Airport.h40463.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/10000000/9330000/9330000/9329921/a5ac356f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/10000000/9330000/9330000/9329921/eeb532f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast on weekdays](https://images.trvl-media.com/lodging/10000000/9330000/9330000/9329921/26f8671b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9330000/9330000/9329921/7752b256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG [](https://www.expedia.ca/San-Antonio-Hotels-Holiday-Inn-Express-Suites-San-Antonio-Medical-Six-Flags.h9329921.Hotel-Information) Northwest Side 7.8/10 Good (1045) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andres CA $129 CA $153 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Antonio-Hotels-Holiday-Inn-Express-Suites-San-Antonio-Medical-Six-Flags.h9329921.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2290000/2281300/2281282/0912999f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/3000000/2290000/2281300/2281282/829c5e0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/3000000/2290000/2281300/2281282/5666ed27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/3000000/2290000/2281300/2281282/9b0e9a24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### WoodSpring Suites San Antonio North Live Oak I-35 [](https://www.expedia.ca/San-Antonio-Hotels-WoodSpring-Suites-San-Antonio-North-Live-Oak-I-35.h2281282.Hotel-Information) Live Oak 6.0/10 (1002) "Staff was very friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shana CA $65 CA $74 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-WoodSpring-Suites-San-Antonio-North-Live-Oak-I-35.h2281282.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1140000/1130500/1130443/60dd96e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/2000000/1140000/1130500/1130443/223d6983.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1140000/1130500/1130443/b78435cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1140000/1130500/1130443/0f44dd40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express San Antonio N-Riverwalk Area by IHG [](https://www.expedia.ca/San-Antonio-Hotels-Holiday-Inn-Express-San-Antonio-N-Riverwalk-Area.h1130443.Hotel-Information) Downtown San Antonio 8.0/10 Very good (1248) "Very convenient location, very friendly staff, clean rooms." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $99 CA $116 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Holiday-Inn-Express-San-Antonio-N-Riverwalk-Area.h1130443.Hotel-Information) ![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/3000000/2270000/2266500/2266474/57995be4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/3000000/2270000/2266500/2266474/w3839h2556x0y3-dd6977b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2270000/2266500/2266474/4d92b759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2270000/2266500/2266474/9676d120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham San Antonio near Frost Bank Center [](https://www.expedia.ca/San-Antonio-Hotels-Days-Inn-Suites-By-Wyndham-San-Antonio-Near-ATT-Center.h2266474.Hotel-Information) Arena District 8.6/10 Excellent (1003) "Great hotel overall!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Keyleen CA $90 CA $105 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Days-Inn-Suites-By-Wyndham-San-Antonio-Near-ATT-Center.h2266474.Hotel-Information) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24266/c2707cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/30000/24300/24266/b75ee751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24300/24266/9d8041d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24266/112d90b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham San Antonio Alamo/Riverwalk [](https://www.expedia.ca/San-Antonio-Hotels-Days-Inn-By-Wyndham-San-Antonio-AlamoRiverwalk.h24266.Hotel-Information) Downtown San Antonio 7.0/10 Good (1280) "Location is incredible for the price " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) paul CA $82 CA $96 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Days-Inn-By-Wyndham-San-Antonio-AlamoRiverwalk.h24266.Hotel-Information) ![Suite, 2 Queen Beds](https://images.trvl-media.com/lodging/3000000/2230000/2221500/2221423/74cbbffb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2230000/2221500/2221423/7fdee8cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/3000000/2230000/2221500/2221423/c9b764f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/3000000/2230000/2221500/2221423/a0053c15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn and Suites Near Medical Center [](https://www.expedia.ca/San-Antonio-Hotels-Comfort-Inn-And-Suites-Near-Medical-Center.h2221423.Hotel-Information) San Antonio 7.2/10 Good (1829) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ana CA $71 CA $89 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Antonio-Hotels-Comfort-Inn-And-Suites-Near-Medical-Center.h2221423.Hotel-Information) ![Seasonal outdoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1860000/1855600/1855506/5f9ac0a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/2000000/1860000/1855600/1855506/d9a75f2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1860000/1855600/1855506/5d5453c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/2000000/1860000/1855600/1855506/92f3f2ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Near Six Flags & Medical Center [](https://www.expedia.ca/San-Antonio-Hotels-Comfort-Inn-Suites-Near-Six-Flags-Medical-Center.h1855506.Hotel-Information) Northwest Side 6.8/10 (1003) "Enjoyed our stay! Very close to Six Flags, purpose of our trip. Everybody that worked there was very nice and polite." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen CA $76 CA $89 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Comfort-Inn-Suites-Near-Six-Flags-Medical-Center.h1855506.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/112000000/111540000/111537300/111537244/fa890cea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Room, 2 Double Beds](https://images.trvl-media.com/lodging/112000000/111540000/111537300/111537244/fcae7f5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/112000000/111540000/111537300/111537244/47b455c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Room, 2 Double Beds](https://images.trvl-media.com/lodging/112000000/111540000/111537300/111537244/9495166d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Flex Studios Culebra [](https://www.expedia.ca/San-Antonio-Hotels-Flex-Studios-Culebra.h111537244.Hotel-Information) San Antonio 6.4/10 (384) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anthony CA $48 CA $57 total includes taxes & fees Jan 12 - Jan 13, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Flex-Studios-Culebra.h111537244.Hotel-Information) ![Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1040000/1037800/1037781/9287ca7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1040000/1037800/1037781/44b55b0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1040000/1037800/1037781/4cffad55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1040000/1037800/1037781/2d1c1119.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 San Antonio, TX - Six Flags [](https://www.expedia.ca/San-Antonio-Hotels-Studio-6-San-Antonio.h1037781.Hotel-Information) Northwest Side 7.2/10 Good (863) "Great location and has everything you need. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tiffany CA $69 CA $87 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Antonio-Hotels-Studio-6-San-Antonio.h1037781.Hotel-Information) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/2000000/1150000/1145500/1145435/5aeccdfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1150000/1145500/1145435/9abcfc90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/2000000/1150000/1145500/1145435/9e2be5e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 10:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1150000/1145500/1145435/8c20011a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton San Antonio Airport [](https://www.expedia.ca/San-Antonio-Hotels-Spark-By-Hilton-San-Antonio-Airport.h1145435.Hotel-Information) Uptown 8.6/10 Excellent (1024) "Great time staying at this location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy CA $88 CA $105 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Spark-By-Hilton-San-Antonio-Airport.h1145435.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/78000000/77840000/77834100/77834089/5e2b541d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/78000000/77840000/77834100/77834089/cfd0b6e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/78000000/77840000/77834100/77834089/394fc13d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/78000000/77840000/77834100/77834089/160c1684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton San Antonio At The Rim, Tx [](https://www.expedia.ca/San-Antonio-Hotels-Tru-By-Hilton-San-Antonio-At-The-Rim.h77834089.Hotel-Information) La Cantera District 8.8/10 Excellent (1001) "Really clean and organized, friendly staff and every thing close by really convenient " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Juan CA $120 CA $142 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Antonio-Hotels-Tru-By-Hilton-San-Antonio-At-The-Rim.h77834089.Hotel-Information) ![Premium bedding, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/d14283e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/9293cc9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/c705af00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/3c09f5e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Extended Stay America Premier Suites - San Antonio - Schertz [](https://www.expedia.ca/San-Antonio-Hotels-Extended-Stay-America-Premier-Suites-San-Antonio-Schertz.h110167699.Hotel-Information) Schertz 9.2/10 Wonderful (148) "Very clean, convenient location, very nice staff.. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LIEZL CA $107 CA $123 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/San-Antonio-Hotels-Extended-Stay-America-Premier-Suites-San-Antonio-Schertz.h110167699.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/990000/981000/980982/58d8c756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/990000/981000/980982/1e3d01f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/990000/981000/980982/bb907d9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/981000/980982/9020de3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX - West SeaWorld [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h980982.Hotel-Information) Far West Side 6.0/10 (1003) "Parking was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) courtney CA $58 CA $69 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h980982.Hotel-Information) ![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/cabe2252.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, dining tables](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/c7209e52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/cae56637.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/07a845c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 San Antonio, TX - Medical Center [](https://www.expedia.ca/San-Antonio-Hotels-Studio-6-San-Antonio.h50914.Hotel-Information) Medical Center District 6.6/10 (787) "Staff and amenities " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Keyshia CA $71 CA $87 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-Studio-6-San-Antonio.h50914.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Medical-Center-District-San-Antonio-Hotels.s20-n553248635978913844-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Medical-Center-District-San-Antonio-Hotels.s20-n553248635978913844-0.Travel-Guide-Filter-Hotels) ## Explore similar 3-star hotels Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in Medical Center District. ![Crockett Hotel](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/a3dd07e6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Crockett Hotel 320 Bonham San Antonio TX CA $123 CA $145 total Dec 21 - Dec 22 includes taxes & fees 8.8/10 Excellent! (2,505 reviews) [](https://expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/544ec14c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk 303 Blum Street San Antonio TX CA $98 CA $140 total Dec 15 - Dec 16 includes taxes & fees 7.8/10 Good! (3,769 reviews) [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) ![Drury Plaza Hotel San Antonio Riverwalk](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Drury Plaza Hotel San Antonio Riverwalk 105 S Saint Marys Street San Antonio TX CA $165 CA $195 total Dec 16 - Dec 17 includes taxes & fees 9.4/10 Exceptional! (4,097 reviews) [](https://expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) Still don't see what you're looking for? [See all properties in Medical Center District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=20) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=20&star=20&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=20&star=20&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=20&star=20&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=20&star=20&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248635978913844&star=20&star=20&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. 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