Title: 22nd Street Station Guest Houses from CA $407 | Expedia.ca [22nd Street Station Hotels](https://expedia.ca/22nd-Street-Station-Hotels.d6173593.Travel-Guide-Hotels)[Potrero Hill Car Rentals](https://expedia.ca/Car-Rentals-In-Potrero-Hill.d506137.Car-Rental-Guide)[Potrero Hill Vacation Packages](https://expedia.ca/Potrero-Hill.d506137.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Guest Houses in 22nd Street Station from CA $407 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6173593&startDate=2026-01-02&endDate=2026-01-04&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6173593&startDate=2026-01-09&endDate=2026-01-11&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6173593&startDate=2026-01-23&endDate=2026-01-25&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=6173593&startDate=2026-02-20&endDate=2026-02-22&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for 22nd Street Station guest houses ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34820000/34816000/34815926/436a586e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/35000000/34820000/34816000/34815926/cf436bdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/35000000/34820000/34816000/34815926/48d86733.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, Netflix, books, streaming services](https://images.trvl-media.com/lodging/35000000/34820000/34816000/34815926/6876cf6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Spacious Modern Potrero Garden Oasis Suite [](https://www.expedia.ca/San-Francisco-Hotels-Private-Spacious-Modern-Potrero-Garden-Oasis-Suite.h34815926.Hotel-Information) Potrero Hill 9.6/10 Exceptional (54) "Super easy check in. Good location with plenty of parking. Clean, maybe a little dated, but it had everything we needed. We enjoyed our stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dawn R. CA $202 CA $407 total includes taxes & fees Jan 22 - Jan 23, 2026 [](https://www.expedia.ca/San-Francisco-Hotels-Private-Spacious-Modern-Potrero-Garden-Oasis-Suite.h34815926.Hotel-Information) ![Smart TV, books, offices](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863914/e57d781f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863914/a2438164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863914/2fc9c005.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863914/a084a8da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Entire House | 700+ Mbps Wifi | City Views [](https://www.expedia.ca/San-Francisco-Hotels-Entire-House-500-Mbps-Internet-City-Views.h100863914.Hotel-Information) Bernal Heights 10/10 Exceptional (3) "The unit‘s I set up very nicely, and the views unique. For our purposes, with three couples and a infant with the need to set up in Bernal Heights neighborhood-it was perfect.Call communication was good and everything in the building exceeded expectations." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tim S. CA $889 CA $1,144 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Francisco-Hotels-Entire-House-500-Mbps-Internet-City-Views.h100863914.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863916/8764fda6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863916/2c5dc178.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863916/79eee0f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863916/8ad988ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 700+Mbps Wifi | Downstairs Space | Backyard BBQ [](https://www.expedia.ca/San-Francisco-Hotels-500Mbps-Wifi-Downstairs-Space-Backyard-BBQ.h100863916.Hotel-Information) Bernal Heights 10/10 Exceptional (1) "Great place and friendly hosts. Would definitely stay again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nicolette S. CA $422 CA $543 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Francisco-Hotels-500Mbps-Wifi-Downstairs-Space-Backyard-BBQ.h100863916.Hotel-Information) ![Smart TV, books](https://images.trvl-media.com/lodging/100000000/99970000/99962000/99961989/0ca0a39c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/100000000/99970000/99962000/99961989/6a7440a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99970000/99962000/99961989/62ff06f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/100000000/99970000/99962000/99961989/32d4d61f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Skyline Views | 700+Mbps Wifi | Hip Bernal Home [](https://www.expedia.ca/San-Francisco-Hotels-Skyline-Views-700Mbps-Wifi-Hip-Bernal-Home.h99961989.Hotel-Information) Bernal Heights 8.8/10 Excellent (9) "We absolutely loved our stay at this stunning top-floor rental in Bernal Heights! The apartment was bright, spotless, and tastefully decorated, creating a cozy and welcoming atmosphere. The neighborhood felt very safe and is ideally located, with great restaurants, cafes, and parks all within easy walking distance. The hosts were incredibly responsive and made the check-in process seamless. It was the perfect home base for exploring San Francisco, and we wouldn’t hesitate to stay here again.... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margarita B. CA $521 CA $676 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/San-Francisco-Hotels-Skyline-Views-700Mbps-Wifi-Hip-Bernal-Home.h99961989.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-07&endDate=2026-01-08®ionId=6173593&adults=2&lodging=GUEST_HOUSE&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F22nd-Street-Station-Guest-Houses.d6173593-aaGuestHouses.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F22nd-Street-Station-Guest-Houses.d6173593-aaGuestHouses.Travel-Guide-Accommodation) ## Top 22nd Street Station Hotel Reviews ![Beacon Grand, A Union Square Hotel ](https://images.trvl-media.com/lodging/1000000/20000/15300/15254/6f8c6b2f_y.jpg) ### Beacon Grand, A Union Square Hotel 10/10 Excellent "View was amazing " [](https://expedia.ca/San-Francisco-Hotels-Sir-Francis-Drake-Hotel.h15254.Hotel-Information) ![Hilton San Francisco Financial District](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/77af977e_y.jpg) ### Hilton San Francisco Financial District 10/10 Excellent "Good" [](https://expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information) ![Hyatt Place San Francisco Downtown](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/fc76649d_y.jpg) ### Hyatt Place San Francisco Downtown 10/10 Excellent "Front desk staff was friendly and extremely professional. Great experience there." [](https://expedia.ca/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information) ![Handlery Union Square Hotel](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462_y.jpg) ### Handlery Union Square Hotel 10/10 Excellent "Very friendly staff. " [](https://expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information) ![Hotel Nikko San Francisco](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/6c2cdc12_y.jpg) ### Hotel Nikko San Francisco 10/10 Excellent "Front desk staff was incredible " [](https://expedia.ca/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information) ![Fairmont San Francisco](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/6f6889e4_y.jpg) ### Fairmont San Francisco 10/10 Excellent "Staff is great and received an unexpected upgrade!" [](https://expedia.ca/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information) ![Holiday Inn Golden Gateway by IHG](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/9ba9bb1f_y.jpg) ### Holiday Inn Golden Gateway by IHG 10/10 Excellent "Clean" [](https://expedia.ca/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information) ![InterContinental San Francisco by IHG](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/5800bbe5_y.jpg) ### InterContinental San Francisco by IHG 10/10 Excellent "Gina at the front desk is great, informative and friendly!" [](https://expedia.ca/San-Francisco-Hotels-InterContinental-San-Francisco.h1766605.Hotel-Information) ![FOUND Hotel Carlton, Nob Hill](https://images.trvl-media.com/lodging/104000000/103130000/103126600/103126565/818bb89d_y.jpg) ### FOUND Hotel Carlton, Nob Hill 10/10 Excellent "The staff was amazing.The room was clean if I had to say anything bad about it.It was loud outside the hotel, but other than that, it was an awesome place to stay" [](https://expedia.ca/San-Francisco-Hotels-FOUND-Hotel-San-Francisco-Carlton.h103126565.Hotel-Information) ## Find out more about 22nd Street Station #### What types of Guest Houses can I find in 22nd Street Station? When you’re looking for 22nd Street Station Guest Houses in 2026, you can use Expedia’s filters to find accommodation that’s family-friendly or business-friendly, and narrow down your search results by amenities, price per night, and much more. For example, you can search for Guest Houses that welcome pets, or one with accessibility features. You’ll find a range of places to stay to suit every budget, so if you're looking for cheap Guest Houses in 22nd Street Station, use our simple search function to help you secure a good deal. If the exact location of Guest Houses is important to you, try our map facility to view available places in relation to each other and to 22nd Street Station. #### How much do Guest Houses cost in 22nd Street Station? Prices for 22nd Street Station Guest Houses can start from as little as CA $407\* in 2026\. The cost per night varies depending on several factors, including the amenities on offer at Guest Houses, the exact location of Guest Houses and how far they are from 22nd Street Station, as well as how high the demand for accommodation is near 22nd Street Station on the dates of your booking. At Expedia, we cater for every budget, so if you’re looking for cheap Guest Houses in 22nd Street Station, you can sleep easy knowing that we’ll help you to secure some of the very best deals on offer. #### How to find the best deals on 22nd Street Station Guest Houses? Expedia’s search function can help you find a great deal on 22nd Street Station Guest Houses. Changing the sort order of your search results can help you to find cheap Guest Houses in 22nd Street Station at a glance. If you have a specific price range in mind, try selecting minimum and maximum prices per night to narrow your results. You can also filter by guest ratings and star ratings to find some of the best offers for Guest Houses within your budget. Don’t forget, if you’re an Expedia Rewards member, you can use the ‘Member Prices’ filter to make instant savings on your booking. #### Why should I choose Expedia to book 22nd Street Station Guest Houses? One of the many benefits of booking 22nd Street Station Guest Houses with Expedia is the clear and simple search function. When you use the many filters on offer, you can easily compile a shortlist of fantastic places to stay, and make comparisons between the different Guest Houses so that you can choose exactly what you need. At Expedia, it’s possible to create your own customized package and make great savings by booking flights, car hire, and more at the same time as 22nd Street Station Guest Houses. And don’t forget that with free membership to Expedia Rewards, you can earn points on all eligible purchases, and build your points total to use towards future travel. #### What is the cancellation policy on booking 22nd Street Station Guest Houses? It’s often possible to change or cancel bookings at 22nd Street Station Guest Houses without a fee, but it depends on the rules and restrictions of the various Guest Houses. Many booking options offer a window of flexibility, for example a full refund if you cancel more than 24 or 48 hours before 22nd Street Station arrival dates. It’s best to check the policies of the individual Guest Houses before making a booking, if flexibility is important to you. You can filter for the ‘Fully refundable’ payment type when you search for Guest Houses. You can also view the terms of the different Guest Houses at any time by checking the details of your booking at Expedia. \*Prices and availability are subject to change. 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