Title: 22nd Street Station Guest Houses from CA $468 | Expedia.ca [22nd Street Station Hotels](https://expedia.ca/22nd-Street-Station-Hotels.d6173593.Travel-Guide-Hotels)[Potrero Hill Car Rentals](https://expedia.ca/Car-Rentals-In-Potrero-Hill.d506137.Car-Rental-Guide)[Potrero Hill Vacation Packages](https://expedia.ca/Potrero-Hill.d506137.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Mar 6 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=6173593&startDate=2026-03-06&endDate=2026-03-08&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6173593&startDate=2026-03-13&endDate=2026-03-15&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=6173593&startDate=2026-03-27&endDate=2026-03-29&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Apr 24 - Apr 26](https://www.expedia.ca/Hotel-Search?regionId=6173593&startDate=2026-04-24&endDate=2026-04-26&adults=2&lodging=GUEST_HOUSE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for 22nd Street Station guest houses ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34820000/34816000/34815926/436a586e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/35000000/34820000/34816000/34815926/cf436bdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/35000000/34820000/34816000/34815926/03e2d05f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/35000000/34820000/34816000/34815926/48d86733.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Spacious Modern Potrero Garden Oasis Suite [](https://www.expedia.ca/San-Francisco-Hotels-Private-Spacious-Modern-Potrero-Garden-Oasis-Suite.h34815926.Hotel-Information) Potrero Hill 9.6/10 Exceptional (54 reviews) "We enjoyed our stay here as a family of four. Our kids made good use of the backyard and it was a comfortable space for us to stay following all of our San Franciscan adventures." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jean O. CA $248 CA $468 total includes taxes & fees Mar 11 - Mar 12 [](https://www.expedia.ca/San-Francisco-Hotels-Private-Spacious-Modern-Potrero-Garden-Oasis-Suite.h34815926.Hotel-Information) ![Smart TV, books, offices](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863914/e57d781f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863914/a084a8da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, offices](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863914/ce33b2cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863914/2fc9c005.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Easy Parking | 15 Min to Union Square | Stocked Kitchen [](https://www.expedia.ca/San-Francisco-Hotels-Entire-House-500-Mbps-Internet-City-Views.h100863914.Hotel-Information) Bernal Heights 10/10 Exceptional (4 reviews) "The unit‘s I set up very nicely, and the views unique. For our purposes, with three couples and a infant with the need to set up in Bernal Heights neighborhood-it was perfect.Call communication was good and everything in the building exceeded expectations." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tim S. [](https://www.expedia.ca/San-Francisco-Hotels-Entire-House-500-Mbps-Internet-City-Views.h100863914.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863916/8764fda6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863916/8ad988ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863916/79eee0f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100870000/100864000/100863916/2c5dc178.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 15-Min to Moscone | Work Table | Modern Setting [](https://www.expedia.ca/San-Francisco-Hotels-500Mbps-Wifi-Downstairs-Space-Backyard-BBQ.h100863916.Hotel-Information) Bernal Heights 9.4/10 Exceptional (3 reviews) "Great place and friendly hosts. Would definitely stay again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nicolette S. CA $405 CA $523 total includes taxes & fees Mar 3 - Mar 4 [](https://www.expedia.ca/San-Francisco-Hotels-500Mbps-Wifi-Downstairs-Space-Backyard-BBQ.h100863916.Hotel-Information) ![Smart TV, books](https://images.trvl-media.com/lodging/100000000/99970000/99962000/99961989/0ca0a39c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/100000000/99970000/99962000/99961989/6a7440a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/100000000/99970000/99962000/99961989/5839bf55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/100000000/99970000/99962000/99961989/32d4d61f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Views | Top Floor | 700+Mbps Wifi [](https://www.expedia.ca/San-Francisco-Hotels-Skyline-Views-700Mbps-Wifi-Hip-Bernal-Home.h99961989.Hotel-Information) Bernal Heights 9.0/10 Wonderful (11 reviews) "We absolutely loved our stay at this stunning top-floor rental in Bernal Heights! The apartment was bright, spotless, and tastefully decorated, creating a cozy and welcoming atmosphere. The neighborhood felt very safe and is ideally located, with great restaurants, cafes, and parks all within easy walking distance. The hosts were incredibly responsive and made the check-in process seamless. It was the perfect home base for exploring San Francisco, and we wouldn’t hesitate to stay here again.... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margarita B. CA $508 CA $659 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/San-Francisco-Hotels-Skyline-Views-700Mbps-Wifi-Hip-Bernal-Home.h99961989.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-11&endDate=2026-03-12®ionId=6173593&adults=2&lodging=GUEST_HOUSE&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F22nd-Street-Station-Guest-Houses.d6173593-aaGuestHouses.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F22nd-Street-Station-Guest-Houses.d6173593-aaGuestHouses.Travel-Guide-Accommodation) ## Top 22nd Street Station Hotel Reviews ![Hotel Nikko San Francisco](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/6c2cdc12_y.jpg) ### Hotel Nikko San Francisco 10/10 Excellent "Kat at reception was great and very friendly during our stay" [](https://expedia.ca/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information) ![Club Quarters Hotel in San Francisco](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27_y.jpg) ### Club Quarters Hotel in San Francisco 10/10 Excellent "Great staff clean room and all that just kept " [](https://expedia.ca/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information) ![Hilton San Francisco Union Square](https://images.trvl-media.com/lodging/1000000/30000/25700/25622/e6c58ddf_y.jpg) ### Hilton San Francisco Union Square 10/10 Excellent "The Amenities were Awesome here! Not to mention location was right in center of Union Square. Everything was in walking distance. And Lobby had everything you needed! Awesome Coffee Shop! " [](https://expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Union-Square.h25622.Hotel-Information) ![Hyatt Regency San Francisco](https://images.trvl-media.com/lodging/1000000/30000/23800/23774/1f7903cc_y.jpg) ### Hyatt Regency San Francisco 10/10 Excellent "We love this place. It’s in a perfect location. Clean room. And a fun elevator ride. Only thing they could do better are the pillows. Ours we super flat and very uncomfortable. " [](https://expedia.ca/San-Francisco-Hotels-Hyatt-Regency-San-Francisco.h23774.Hotel-Information) ![Hilton San Francisco Financial District](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/77af977e_y.jpg) ### Hilton San Francisco Financial District 10/10 Excellent "Staff so helpful. Very clean room, comfy bed, and great view of the bay. Wonderful location for getting to North Beach, Chinatown, and anywhere else you’d like to go with rapid transit. (Bus just a few steps away!). Also made use of their in n out parking privileges until 3 on checkout day which allowed to explore the city more before we needed to leave. Will definitely stay again!" [](https://expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information) ![YOTEL San Francisco](https://images.trvl-media.com/lodging/20000000/19520000/19510300/19510249/e1a4da25_y.jpg) ### YOTEL San Francisco 10/10 Excellent "Great stay" [](https://expedia.ca/San-Francisco-Hotels-YOTEL-San-Francisco.h19510249.Hotel-Information) ![Holiday Inn Express and Suites Fisherman's Wharf by IHG](https://images.trvl-media.com/lodging/1000000/580000/578900/578899/b406d764_y.jpg) ### Holiday Inn Express and Suites Fisherman's Wharf by IHG 10/10 Excellent "Staff was friendly and welcoming" [](https://expedia.ca/San-Francisco-Hotels-Holiday-Inn-Express-And-Suites-Fishermans-Wharf.h578899.Hotel-Information) ![Hotel Zephyr San Francisco](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/fd976170_y.jpg) ### Hotel Zephyr San Francisco 10/10 Excellent "We loved the hotel. The game room is great. We felt like it was in a great area and close to all the places we wanted to go. The concierge, Tatiana was super helpful. " [](https://expedia.ca/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information) ![Holiday Inn Golden Gateway by IHG](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/9ba9bb1f_y.jpg) ### Holiday Inn Golden Gateway by IHG 10/10 Excellent "Clean room, good location." [](https://expedia.ca/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AA_SPRING_PROMO_6173593) ## Find out more about 22nd Street Station #### What types of Guest Houses can I find in 22nd Street Station? When you’re looking for 22nd Street Station Guest Houses in 2026, you can use Expedia’s filters to find accommodation that’s family-friendly or business-friendly, and narrow down your search results by amenities, price per night, and much more. For example, you can search for Guest Houses that welcome pets, or one with accessibility features. You’ll find a range of places to stay to suit every budget, so if you're looking for cheap Guest Houses in 22nd Street Station, use our simple search function to help you secure a good deal. If the exact location of Guest Houses is important to you, try our map facility to view available places in relation to each other and to 22nd Street Station. #### How much do Guest Houses cost in 22nd Street Station? Prices for 22nd Street Station Guest Houses can start from as little as CA $468\* in 2026\. The cost per night varies depending on several factors, including the amenities on offer at Guest Houses, the exact location of Guest Houses and how far they are from 22nd Street Station, as well as how high the demand for accommodation is near 22nd Street Station on the dates of your booking. At Expedia, we cater for every budget, so if you’re looking for cheap Guest Houses in 22nd Street Station, you can sleep easy knowing that we’ll help you to secure some of the very best deals on offer. #### How to find the best deals on 22nd Street Station Guest Houses? Expedia’s search function can help you find a great deal on 22nd Street Station Guest Houses. Changing the sort order of your search results can help you to find cheap Guest Houses in 22nd Street Station at a glance. If you have a specific price range in mind, try selecting minimum and maximum prices per night to narrow your results. You can also filter by guest ratings and star ratings to find some of the best offers for Guest Houses within your budget. Don’t forget, if you’re an Expedia Rewards member, you can use the ‘Member Prices’ filter to make instant savings on your booking. #### Why should I choose Expedia to book 22nd Street Station Guest Houses? One of the many benefits of booking 22nd Street Station Guest Houses with Expedia is the clear and simple search function. When you use the many filters on offer, you can easily compile a shortlist of fantastic places to stay, and make comparisons between the different Guest Houses so that you can choose exactly what you need. At Expedia, it’s possible to create your own customized package and make great savings by booking flights, car hire, and more at the same time as 22nd Street Station Guest Houses. And don’t forget that with free membership to Expedia Rewards, you can earn points on all eligible purchases, and build your points total to use towards future travel. #### What is the cancellation policy on booking 22nd Street Station Guest Houses? It’s often possible to change or cancel bookings at 22nd Street Station Guest Houses without a fee, but it depends on the rules and restrictions of the various Guest Houses. Many booking options offer a window of flexibility, for example a full refund if you cancel more than 24 or 48 hours before 22nd Street Station arrival dates. It’s best to check the policies of the individual Guest Houses before making a booking, if flexibility is important to you. You can filter for the ‘Fully refundable’ payment type when you search for Guest Houses. You can also view the terms of the different Guest Houses at any time by checking the details of your booking at Expedia. \*Prices and availability are subject to change. 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