Title: 10 Best Hotels in South Main, Houston for 2025 | Expedia.ca

  

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# Hotels in South Main, Houston

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## Go beyond your typical stay in South Main

Pool

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&amenities=POOL)

Apart hotel

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&lodging=APART_HOTEL)

Spa

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&amenities=SPA_ON_SITE)

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&travelerType=family_friendly)

Cottage

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&lodging=COTTAGE)

Condo

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&lodging=CONDO)

Apart­ment

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&lodging=APARTMENT)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&amenities=PETS)

Hot tub

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&amenities=HOT_TUB)

Waterpark

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&amenities=WATER_PARK)

Villa

[](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America&regionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-11-01&d1=2025-11-01&endDate=2025-11-03&d2=2025-11-03&lodging=VILLA)

## Check prices for these dates

Tonight

[Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-18&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-19&endDate=2025-10-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## South Main hotels and places to stay

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/w2558h1440x0y0-44773629.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Food and drink](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/83265e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 10:00 AM to 6:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/e04a9b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Ballroom](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/63833027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Wyndham Houston near NRG Park/Medical Center

South Main

7.2/10

Good

(1180)

"Everyone was very pleasant, I will be returning."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Amy

CA $139

CA $162 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information)

![1 bedroom, hypo-allergenic bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/3135be14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/c101e36a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/b55cbe72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/1e7f9dd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn & Suites NRG Park - Medical Center

South Main

6.6/10

(1008)

"The rooms were clean, the beds were soft, the staff was friendly. The breakfast wasnt bad either. It was literally the best bang for our buck. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carolina

CA $83

CA $97 total

includes taxes & fees

Nov 17 - Nov 18

[](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information)

![Gazebo](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/ab4b9445.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/54d3b468.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/6b2e094a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/bdf24163.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Wingate Houston near NRG Park/Medical Center

South Main

6.6/10

(946)

"Walking distance to NRG Stadium "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Corina

CA $111

CA $130 total

includes taxes & fees

Oct 27 - Oct 28

[](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/168bdeac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/13fb2418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Full-size fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/14da1a00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/b0f701b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Candlewood Suites Houston Medical Center by IHG

South Main

7.4/10

Good

(802)

"The staff is great. The area is questionable due to homeless population."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bryana

CA $104

CA $121 total

includes taxes & fees

Oct 20 - Oct 21

[](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/0afdb877.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Individually decorated, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/d9a5db5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/a1271476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/28e82f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Suites Houston near Medical Center- NRG Stadium

South Main

8.6/10

Excellent

(996)

"Loved staying at the Comfort Suites ."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Linda

CA $112

CA $131 total

includes taxes & fees

Nov 17 - Nov 18

[](https://www.expedia.ca/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/c40a6103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite (Composer) | Dining room](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/f9f8ae11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/077747b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/dd9a3669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Lancaster Hotel

Downtown Houston, 11.1 km from South Main

9.8/10

Exceptional

(1011)

"Great place... lots of nice people and nice rooms."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kenneth

CA $278

CA $325 total

includes taxes & fees

Oct 26 - Oct 27

[](https://www.expedia.ca/Houston-Hotels-The-Lancaster-Hotel.h13295.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/89000000/88140000/88130500/88130440/a6f86b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/89000000/88140000/88130500/88130440/f8237fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/89000000/88140000/88130500/88130440/eec7b544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/89000000/88140000/88130500/88130440/71ab7d99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

9.2/10

Wonderful

(2039)

"Great place to stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jason

CA $195

CA $229 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/Houston-Hotels-Hyatt-Place-Houston-Medical-Center.h88130440.Hotel-Information)

![Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/9a708987.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/55e246fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/5138e12a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/b1e04b0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency Houston/Galleria

The Galleria, 8.7 km from South Main

9.0/10

Wonderful

(1102)

"Wonderful property!!! Very much enjoyed our stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Matthew

CA $216

CA $254 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/Houston-Hotels-Hyatt-Regency-HoustonGalleria.h10620692.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/ec3f4d74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, down comforters, in-room safe, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/71078c26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, down comforters, in-room safe, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/d7c28c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### DoubleTree by Hilton Hotel & Suites Houston by the Galleria

8.9 km from South Main

8.2/10

Very good

(2705)

"We had a wonderful stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laquinza

CA $171

CA $202 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information)

![City view from property](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/ebaa4874.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/31209257.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cocktail bar](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/0c8e0486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Whitehall Houston

Houston Central Business District, 10 km from South Main

8.6/10

Excellent

(1809)

"Great staff nice rooms"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Matthew

CA $200

CA $235 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/Houston-Hotels-The-Whitehall-Houston.h693655.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/dc9d050c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/w3837h2505x3y0-1cfabad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/40a5bc26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![50-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/w3836h2556x4y4-af1501b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Blossom Hotel Houston, Curio Collection by Hilton

Texas Medical Center, 3.5 km from South Main

9.0/10

Wonderful

(3563)

"Great stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alexis

CA $185

CA $216 total

includes taxes & fees

Nov 16 - Nov 17

[](https://www.expedia.ca/Houston-Hotels-Blossom-Hotel-Houston.h58985846.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/84000000/83760000/83751000/83750993/31c2b88f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/84000000/83760000/83751000/83750993/1d77a540.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/84000000/83760000/83751000/83750993/f81e2b4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Suite, 1 King Bed (1 Bedroom)](https://images.trvl-media.com/lodging/84000000/83760000/83751000/83750993/w6142h3840x5y0-1df7f040.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt House Houston Medical Center

Texas Medical Center, 3.1 km from South Main

9.2/10

Wonderful

(1135)

"Great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kurt

CA $195

CA $229 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/Houston-Hotels-Hyatt-House-Houston-Medical-Center.h83750993.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/79071c33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Nightclub](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/w6992h4673x0y8-ea923e10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/516b3f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Omni Houston Hotel

10.6 km from South Main

9.0/10

Wonderful

(1019)

"Really enjoyed my stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

kenneth

CA $268

CA $318 total

includes taxes & fees

Nov 9 - Nov 10

[](https://www.expedia.ca/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information)

![Breakfast, lunch, brunch served; American cuisine, garden views ](https://images.trvl-media.com/lodging/1000000/20000/12400/12378/7e4ad465.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12400/12378/729ec87e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12400/12378/06b8ac16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12400/12378/e693d863.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency Houston West

23.2 km from South Main

8.6/10

Excellent

(1202)

"Great stay for work trips."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

esther

CA $163

CA $190 total

includes taxes & fees

Oct 25 - Oct 26

[](https://www.expedia.ca/Houston-Hotels-Hyatt-Regency-Houston-West.h12378.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/70000/67600/67561/875dd499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/70000/67600/67561/e45aa8e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/70000/67600/67561/0c819a97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/70000/67600/67561/6a5f2f0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham Houston Southwest

9.4 km from South Main

7.0/10

Good

(1023)

"Great stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Larissa

CA $91

CA $106 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/Houston-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Houston-Southwest.h67561.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, City View | View from room](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/a6761ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/b032cc4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, Egyptian cotton sheets, premium bedding, pillowtop beds](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/w3836h2556x4y4-d736e03c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Royal Sonesta Houston Galleria

The Galleria, 8.8 km from South Main

8.4/10

Very good

(1297)

"Great hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chad

CA $167

CA $195 total

includes taxes & fees

Nov 16 - Nov 17

[](https://www.expedia.ca/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/aa7fafd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 Queen Bed](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/c91eaea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/c1fa2b90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Club Quarters Hotel Downtown, Houston

Houston Central Business District, 10.9 km from South Main

8.4/10

Very good

(3799)

"Lovely place to STAY’nm"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tiwan

CA $139

CA $162 total

includes taxes & fees

Nov 17 - Nov 18

[](https://www.expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/73000000/72510000/72510000/72509948/02126088.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/73000000/72510000/72510000/72509948/40188cb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/73000000/72510000/72510000/72509948/0f298d6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, in-room safe, desk, soundproofing](https://images.trvl-media.com/lodging/73000000/72510000/72510000/72509948/a772e6cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Houston – Downtown North by IHG

Northside, 13.7 km from South Main

9.2/10

Wonderful

(594)

"Staff was friendly, room was clean, and quiet area!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mary

CA $167

CA $195 total

includes taxes & fees

Oct 22 - Oct 23

[](https://www.expedia.ca/Houston-Hotels-Holiday-Inn-Express-Suites-Houston-N-Downtown.h72509948.Hotel-Information)

![Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/e02c73c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily full breakfast](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/be7d736f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/18c0750c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/8863ac84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Haven Inn & Suites Downtown Houston

North Houston, 18.8 km from South Main

9.4/10

Exceptional

(1018)

"Very clean and safe, would stay again"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Krimson

CA $91

CA $106 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/Houston-Hotels-Haven-Inn-Suites-Downtown-Houston.h18122141.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/450000/447900/447810/5002086e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/450000/447900/447810/4732a92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/450000/447900/447810/41c29f8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/450000/447900/447810/b3ca5c88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sonesta ES Suites Houston Galleria

The Galleria, 8.4 km from South Main

8.2/10

Very good

(1118)

"Nice stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steven

CA $166

CA $194 total

includes taxes & fees

Oct 22 - Oct 23

[](https://www.expedia.ca/Houston-Hotels-Sonesta-ES-Suites-Houston-Galleria.h447810.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-01&endDate=2025-11-02&regionId=553248635976386992&adults=2&sort=RECOMMENDED&openPlayBack=true)

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## Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

-   Downtown Houston
-   The Galleria
-   Texas Medical Center
-   Montrose
-   Houston Central Business District

![Discovery Green which includes city views, a square or plaza and a skyscraper](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23540-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Discovery Green showing a park, a skyscraper and street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34453-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/507000/507468-downtown-houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/507000/507497-downtown-houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Discovery Green showing a statue or sculpture, a high-rise building and modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34451-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=800037)

![Downtown Houston map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:s%7CrtDz%7BbeQiQ_%40eEcBgCkDuQ%7D_%40m%5EeQ%7EMi%5DoAePiLi%60%40m%40%7DTlCsl%40pNj%5CxWzUxS%60Bv%7CAhmAcg%40ncAuI%60DmZx%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=WgKNf3zxiTWREKGzy8I1t3uy5Hs=)

### Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=800037)

![](https://mediaim.expedia.com/destination/1/733d46a93b53c864b5c00945f6416b51.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/1/d7dc12b9d267be169566d38db8ea7eac.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/7/01538c9f6eb646ea96e3df2059618b27.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/7/374a9a687602bd093583e97522a04bc6.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/9/aadfd687906d99829a520409ec046d47.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=501263)

![The Galleria map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7DxptDn%7DteQ_AcXqKr%40mHsB%7BXT%5DgYeZY%3F%7D%60%40jGi%40rA_HxCyFTuIpzAsBbBt%7D%40fw%40%60NdA%7Ce%40szAdB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=5e77b0krOIeDwBK5_jkO84swezY=)

### The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=501263)

![](https://mediaim.expedia.com/destination/1/f4655cac96c82fca6c00f4ab3162178c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/7/29187be13ac57fa24b0f672247c7afbc.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/7/52a59f2a0bfb2cf153bbc44f917f7275.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=6143504)

![Texas Medical Center map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wbftD%7C%60keQyBu%40u%5DkXgZySqC%7EG%7DEnG%7DQrDyAw%60%40aa%40gYrCsKe%5BcW%7CM_UbGi%40%60LmLjQmE%5DmPvB%60%40vEoQhGyJnDgKjKlC%7DDbTqAUq%40lDrYtHbGdd%40nKsDlOe%40bW%60Oj%40d_%40%7BFd%40%3FdRmCpA%3FdAtC%7CDL%60_%40eF%3F%7B%40uFiDf%40AqAwBB%7BC%60Ae%40yCm%40OlBhOjId%60%40hAnC&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=-txg4h32BKxrIPBjQzTWKWRnz0I=)

### Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=6143504)

![Menil Collection which includes interior views and art](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23619-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Menil Collection featuring interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23623-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Menil Collection showing interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34667-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Menil Collection featuring a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34665-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34668-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=3000663145)

![Montrose map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wiptDf%7CieQmBWy%7E%40R%7BAe%40qByG_CiCwQJiG%60%40X%7BBoAyGIeOwDsLe%40qDh%40uJ%7D%40sCSsDuCkJJyE%60AsGLaMnD%7DQBcLreAQGwItTKI_MvFAb%40a%40rNdApW%40nf%40l%5D%60BlBnFpdBf%40tTElUyoA%5C&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=FA9GMjOoslAVD7SwHDyMnspJbfU=)

### Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=3000663145)

![Houston featuring a city and a skyscraper](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34818-Houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Houston showing night scenes and a sporting event](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/21000/21517-Houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Greater Houston Convention and Visitors Bureau

![Space Center Houston which includes aircraft](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34685-Space-Center-Houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Houston featuring skyline, a city and modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/21000/21508-Houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Greater Houston Convention and Visitors Bureau

![Houston featuring a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/21000/21512-Houston-Museum-Of-Fine-Arts.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Greater Houston Convention and Visitors Bureau (photographer: Rick Gardner)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=553248635976473213)

![Houston Central Business District map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wfqtD%7EuceQsXeRk%60Ayr%40x%7E%40_jBp%7D%40zp%40qMrVh%5BfUcp%40fqA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=l24t0KYtEnk7l4YWZTxkpNv3bu8=)

### Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976473213)

## Top South Main Hotel Reviews

## Frequently asked questions

### What are the best hotels in South Main that travellers recommend?

> [Wyndham Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) is a solid choice for travellers seeking comfort and convenience, earning a customer review rating of 7.2. This hotel features an inviting outdoor pool, superb for unwinding after a day of adventure, along with kitchenettes in the rooms—ideal for families wanting to prepare snacks or meals. The combination of free WiFi and a 24-hour business centre makes it suitable for both leisure and business travellers, ensuring a straightforward stay.
> 
>   
> 
> For families, [Wingate Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) is another great option. With a complimentary continental breakfast to fuel your adventures and a refreshing outdoor pool, it caters superbly to parents and kids alike. The accessible fitness centre allows for some family fun, while the hotel's pet-friendly policies make it a fantastic choice for those traveling with furry companions. With a focus on convenience and value, this hotel provides excellent amenities while keeping everyone comfortable.

### What are the best family hotels in South Main?

> When it comes to family-friendly hotels in South Main, the [Comfort Suites near Texas Medical Center - NRG Stadium](https://www.expedia.ca/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) shines brightly with a solid traveller review rating of 8.6. This hotel offers daily housekeeping to ensure your family's stay is comfortable and straightforward.
> 
>   
> 
> Another excellent option is the [Candlewood Suites Houston Medical Center by IHG](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information), which boasts a family-friendly atmosphere with its free cribs, connecting rooms, and a sofa bed, making it great for families needing extra space. Guests appreciate the convenience of in-room kitchen amenities like a microwave and dishwasher, allowing for easy meal prep during your stay. It has a review score of 7.6, reflecting its appeal to families on the go.
> 
>   
> 
> For those seeking a place with a pool, the [Quality Inn & Suites NRG Park - Medical Center](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information) is a great choice. With its inviting pool area, free meals for children, and options for rollaway beds at no extra charge, families can enjoy a splash-filled vacation while also benefiting from daily housekeeping and snack options.
> 
>   
> 
> Lastly, the [Wyndham Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) features child-friendly window designs and connecting rooms, catering specifically to families' needs. The presence of kitchenettes adds to the convenience, allowing families to prepare snacks or meals together. This property has a traveller rating of 7.2, making it a reliable choice for family stays.
> 
>   
> 
> These hotels exemplify quality and convenience, ensuring that your family's adventure in South Main is both enjoyable and comfortable.

### What hotels in South Main offer free breakfast?

> [Comfort Suites near Texas Medical Center - NRG Stadium](https://www.expedia.ca/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) is a fantastic option for travellers seeking comfort and convenience in South Main. With a traveller review rating of 8.6, this hotel offers a delightful free full breakfast to start your day right. Families will appreciate the seasonal outdoor pool, superb for a refreshing dip after a day of exploring. Additionally, the property features complimentary WiFi and self-parking, making it easy to stay connected and save on travel expenses.
> 
>   
> 
> Another great choice is [Quality Inn & Suites NRG Park - Medical Center](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information), which also provides a free breakfast, including options for those on the go. This family-friendly hotel offers spacious suites with balconies and patios, allowing families to unwind outdoors. The outdoor pool invites guests to relax and enjoy the Texas sunshine, while the complimentary area shuttle makes it simple to explore the attractions nearby.
> 
>   
> 
> For those traveling without children, the [Wingate Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) presents a delightful blend of comfort and accessibility. With an outdoor pool and fitness centre, it caters to adults looking for a rejuvenating getaway. The hotel's continental breakfast is another perk that guarantees a satisfying start to your morning adventures.

### What are the best budget hotels in South Main?

> [Comfort Suites near Texas Medical Center - NRG Stadium](https://www.expedia.ca/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) is a fantastic budget-friendly option for travellers seeking convenience and quality in South Main. With an excellent review score of 8.6, this hotel offers a range of family-friendly amenities, including a seasonal outdoor pool, free breakfast, and complimentary WiFi. Families will appreciate the spacious rooms and the convenience of free self-parking, making it easy to explore the area together.
> 
>   
> 
> For another appealing choice, [Candlewood Suites Houston Medical Center by IHG](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information) stands out with a review score of 7.6. This property is superb for families, as it features kitchenettes in the rooms, allowing for meal preparation and snacks on the go. Kids can also enjoy the complimentary cribs and sofa beds, making it a comfortable stay for everyone. Additionally, the hotel offers a free area shuttle, which is great for exploring local attractions without the hassle of driving.
> 
>   
> 
> If you're traveling with your partner or friends, the [Wyndham Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) offers a more relaxed atmosphere with a lower review score of 7.2. This hotel features outdoor pool access and convenient amenities, including a kitchenette in some rooms, which can appeal to those looking for a home-like experience while away.
> 
>   
> 
> No matter your travel group, these options in South Main cater to various needs while ensuring a comfortable and enjoyable stay.

### Can I cancel my hotel reservation on Expedia?

> You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in South Main.

### How can I save on a South Main hotel booking with Expedia?

> Members always get our best prices. Find our best South Main hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.

### How much is the nightly rate at a South Main hotel?

> Hotel prices in South Main often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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-   [Astrodome Hotels](https://www.expedia.ca/Astrodome-Houston-Hotels.0-n553248635976007975-0.Travel-Guide-Filter-Hotels)
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-   [Flights to Houston](https://www.expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)
-   [Flights to Southwest Houston](https://www.expedia.ca/Cheap-Flights-To-Southwest-Houston.d6189441.Travel-Guide-Flights)
-   [Flights from Amsterdam to Southwest Houston](https://www.expedia.ca/lp/flights/178229/6189441/amsterdam-to-southwest-houston)
-   [Flights from Atlanta to Southwest Houston](https://www.expedia.ca/lp/flights/178232/6189441/atlanta-to-southwest-houston)
-   [Flights from Auckland to Southwest Houston](https://www.expedia.ca/lp/flights/178233/6189441/auckland-to-southwest-houston)
-   [Flights from Baltimore to Southwest Houston](https://www.expedia.ca/lp/flights/178235/6189441/baltimore-to-southwest-houston)
-   [Flights from Bogotá to Southwest Houston](https://www.expedia.ca/lp/flights/178238/6189441/bogota-to-southwest-houston)
-   [Flights from Calgary to Southwest Houston](https://www.expedia.ca/lp/flights/178245/6189441/calgary-to-southwest-houston)
-   [Flights from Chicago to Southwest Houston](https://www.expedia.ca/lp/flights/178248/6189441/chicago-to-southwest-houston)
-   [Flights from Dallas to Southwest Houston](https://www.expedia.ca/lp/flights/178253/6189441/dallas-to-southwest-houston)
-   [Flights from Detroit to Southwest Houston](https://www.expedia.ca/lp/flights/178255/6189441/detroit-to-southwest-houston)
-   [Flights from Raleigh to Southwest Houston](https://www.expedia.ca/lp/flights/178300/6189441/raleigh-to-southwest-houston)
-   [Flights from Seattle to Southwest Houston](https://www.expedia.ca/lp/flights/178307/6189441/seattle-to-southwest-houston)
-   [Flights from St. Louis to Southwest Houston](https://www.expedia.ca/lp/flights/178309/6189441/st-louis-to-southwest-houston)
-   [Flights from Richmond to Southwest Houston](https://www.expedia.ca/lp/flights/601761/6189441/richmond-to-southwest-houston)

-   [Visit Astrodome](https://www.expedia.ca/Houston-Astrodome.dx553248635976007975)
-   [Visit Southside Place](https://www.expedia.ca/Houston-Southside-Place.dx160529)
-   [Visit Texas Medical Center](https://www.expedia.ca/Houston-Texas-Medical-Center.dx6143504)
-   [Md Anderson Cancer Center](https://www.expedia.ca/MD-Anderson-Cancer-Center-Texas-Medical-Center.d6248539.Vacation-Attraction)
-   [Nrg Stadium](https://www.expedia.ca/NRG-Stadium-Astrodome.d553248635929331916.Vacation-Attraction)
-   [Visit Southwest Houston](https://www.expedia.ca/Southwest-Houston.dx6189441)

-   [Airport Van Rental Rental Cars in Southwest Houston](https://www.expedia.ca/Airport-Van-Rental-Car-Rentals-In-Southwest-Houston.d6189441-c1092.Car-Rental-Guide-Suppliers)
-   [Alamo Rent A Car Rental Cars in Southwest Houston](https://www.expedia.ca/Alamo-Rent-A-Car-Car-Rentals-In-Southwest-Houston.d6189441-c6.Car-Rental-Guide-Suppliers)
-   [Auto Rent Rental Cars in Southwest Houston](https://www.expedia.ca/Auto-Rent-Car-Rentals-In-Southwest-Houston.d6189441-c1006.Car-Rental-Guide-Suppliers)
-   [Budget Rental Cars in Southwest Houston](https://www.expedia.ca/Budget-Car-Rentals-In-Southwest-Houston.d6189441-c39.Car-Rental-Guide-Suppliers)
-   [Discount Quebec Rental Cars in Southwest Houston](https://www.expedia.ca/Discount-Quebec-Car-Rentals-In-Southwest-Houston.d6189441-c1137.Car-Rental-Guide-Suppliers)
-   [Global Rent a Car Rental Cars in Southwest Houston](https://www.expedia.ca/Global-Rent-A-Car-Car-Rentals-In-Southwest-Houston.d6189441-c1062.Car-Rental-Guide-Suppliers)
-   [Goldcar Key’n Go Rental Cars in Southwest Houston](https://www.expedia.ca/Goldcar-Keyn-Go-Car-Rentals-In-Southwest-Houston.d6189441-c1044.Car-Rental-Guide-Suppliers)
-   [Hertz Rental Cars in Southwest Houston](https://www.expedia.ca/Hertz-Car-Rentals-In-Southwest-Houston.d6189441-c40.Car-Rental-Guide-Suppliers)
-   [Localiza Rental Cars in Southwest Houston](https://www.expedia.ca/Localiza-Car-Rentals-In-Southwest-Houston.d6189441-c1063.Car-Rental-Guide-Suppliers)
-   [Locauto Rental Cars in Southwest Houston](https://www.expedia.ca/Locauto-Car-Rentals-In-Southwest-Houston.d6189441-c1140.Car-Rental-Guide-Suppliers)
-   [Nextcar Rental Cars in Southwest Houston](https://www.expedia.ca/Nextcar-Car-Rentals-In-Southwest-Houston.d6189441-c1061.Car-Rental-Guide-Suppliers)
-   [Rent A Wreck Rental Cars in Southwest Houston](https://www.expedia.ca/Rent-A-Wreck-Car-Rentals-In-Southwest-Houston.d6189441-c33.Car-Rental-Guide-Suppliers)

-   [Things to do in Southwest Houston](https://www.expedia.ca/Things-To-Do-In-Southwest-Houston.d6189441.Travel-Guide-Activities)

-   [Book Hotels in South Main on Expedia.com](https://www.expedia.com/South-Main-Houston-Hotels.0-n553248635976386992-0.Travel-Guide-Filter-Hotels)

-   Explore a world of travel with Expedia

### Hotels in top Houston neighborhoods

-   [Hotels in Downtown Houston](https://expedia.ca/Downtown-Houston-Houston-Hotels.0-n800037-0.Travel-Guide-Filter-Hotels)
-   [Hotels in The Galleria](https://expedia.ca/The-Galleria-Houston-Hotels.0-n501263-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Texas Medical Center](https://expedia.ca/Texas-Medical-Center-Houston-Hotels.0-n6143504-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Montrose](https://expedia.ca/Montrose-Houston-Hotels.0-n3000663145-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Houston Central Business District](https://expedia.ca/Houston-Central-Business-District-Houston-Hotels.0-n553248635976473213-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Houston Heights](https://expedia.ca/Houston-Heights-Houston-Hotels.0-n553248633938962798-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Northside](https://expedia.ca/Northside-Houston-Hotels.0-n553248635976387525-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Southeast Houston](https://expedia.ca/Southeast-Houston-Houston-Hotels.0-n553248635976479121-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Midtown](https://expedia.ca/Midtown-Houston-Hotels.0-n6282039-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Washington Ave./ Memorial Park](https://expedia.ca/Washington-Ave-Memorial-Park-Houston-Hotels.0-n553248635976008210-0.Travel-Guide-Filter-Hotels)
-   [Hotels in South Central Houston](https://expedia.ca/South-Central-Houston-Houston-Hotels.0-n553248635976476176-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Houston Museum District](https://expedia.ca/Houston-Museum-District-Houston-Hotels.0-n6164045-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Westchase](https://expedia.ca/Westchase-Houston-Hotels.0-n6129522-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Houston Convention District](https://expedia.ca/Houston-Convention-District-Houston-Hotels.0-n553248627676614067-0.Travel-Guide-Filter-Hotels)
-   [Hotels in River Oaks](https://expedia.ca/River-Oaks-Houston-Hotels.0-n553248635074842911-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Greater Uptown](https://expedia.ca/Greater-Uptown-Houston-Hotels.0-n799025842406584320-0.Travel-Guide-Filter-Hotels)
-   [Hotels in North Houston](https://expedia.ca/North-Houston-Houston-Hotels.0-n553248635074843507-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Memorial](https://expedia.ca/Memorial-Houston-Hotels.0-n6235956-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Greater Third Ward](https://expedia.ca/Greater-Third-Ward-Houston-Hotels.0-n553248635976008254-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Greater Heights](https://expedia.ca/Greater-Heights-Houston-Hotels.0-n553248621532644730-0.Travel-Guide-Filter-Hotels)

### Hotels near popular Houston Attractions

-   [Hotels near NRG Stadium](https://expedia.ca/NRG-Stadium-Hotels.0-l553248635929331916-0.Travel-Guide-Filter-Hotels)
-   [Hotels near MD Anderson Cancer Center](https://expedia.ca/MD-Anderson-Cancer-Center-Hotels.0-l6248539-0.Travel-Guide-Filter-Hotels)
-   [Hotels near George R. Brown Convention Center](https://expedia.ca/George-R-Brown-Convention-Center-Hotels.0-l501247-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Daikin Park](https://expedia.ca/Daikin-Park-Hotels.0-l6034772-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Toyota Center](https://expedia.ca/Toyota-Center-Hotels.0-l6082241-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Rice University](https://expedia.ca/Rice-University-Hotels.0-l501268-0.Travel-Guide-Filter-Hotels)
-   [Hotels near University of Houston](https://expedia.ca/University-Of-Houston-Hotels.0-l501270-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Houston Zoo](https://expedia.ca/Houston-Zoo-Hotels.0-l6082223-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Westheimer Road](https://expedia.ca/Westheimer-Road-Hotels.0-l553248633938962786-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Memorial City Mall](https://expedia.ca/Memorial-City-Mall-Hotels.0-l6178075-0.Travel-Guide-Filter-Hotels)

### Hotels Close to Nearby Airports

-   [Hotels near George Bush Intercontinental Airport](https://expedia.ca/George-Bush-Intercontinental-Airport-Hotels.0-aIAH-0.Travel-Guide-Filter-Hotels)
-   [Hotels near William P. Hobby Airport](https://expedia.ca/William-P-Hobby-Airport-Hotels.0-aHOU-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Sugar Land Regional Airport](https://expedia.ca/Sugar-Land-Regional-Airport-Hotels.0-aSGR-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Ellington Field Airport](https://expedia.ca/Ellington-Field-Airport-Hotels.0-aEFD-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Westchase Helipad Airport](https://expedia.ca/Westchase-Helipad-Airport-Hotels.0-aJWH-0.Travel-Guide-Filter-Hotels)

### More ways to book

-   [Book Hotels in South Main on Expedia.com](https://www.expedia.com/South-Main-Houston-Hotels.0-n553248635976386992-0.Travel-Guide-Filter-Hotels)

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-   [Hotels in Salaberry-de-Valleyfield](https://expedia.ca/Salaberry-De-Valleyfield-Hotels.d181966.Travel-Guide-Hotels)
-   [Downtown Houston hotels](https://expedia.ca/Downtown-Houston-Houston-Hotels.0-n800037-0.Travel-Guide-Filter-Hotels)
-   [All Inclusive Resorts and Hotels in Turks and Caicos](https://expedia.ca/Destinations-In-Turks-And-Caicos-All-Inclusive-Hotel.0-0-d184-tAllInclusiveHotel.Hotel-Filter-Destinations)
-   [Fort Worth Stockyards hotels](https://expedia.ca/Fort-Worth-Stockyards-Fort-Worth-Hotels.0-n6190845-0.Travel-Guide-Filter-Hotels)

Flights

-   [Cheap Flights from Ottawa (YOW) to Orlando (MCO)](https://expedia.ca/lp/flights/yow/mco/ottawa-to-orlando)
-   [Flights from Watertown Intl. Airport](https://expedia.ca/lp/airports/art/flights-from-watertown-intl-airport)
-   [Cheap Flights to Cochrane](https://expedia.ca/Cheap-Flights-To-Cochrane.d3913.Travel-Guide-Flights)
-   [Cheap Flights from Winnipeg (YWG) to Toronto (YYZ)](https://expedia.ca/lp/flights/ywg/yyz/winnipeg-to-toronto)

Packages

-   [Caribbean Vacations](https://expedia.ca/Caribbean.d6022969.Destination-Travel-Guides)
-   [Cancun Vacations](https://expedia.ca/Cancun.d179995.Destination-Travel-Guides)

General

-   [Visit Downtown Dallas](https://expedia.ca/Dallas-Downtown-Dallas.dx800026)
-   [Visit Downtown Houston](https://expedia.ca/Houston-Downtown-Houston.dx800037)
-   [Visit Fort Worth Stockyards](https://expedia.ca/Fort-Worth-Fort-Worth-Stockyards.dx6190845)
-   [Visit Bhutan](https://expedia.ca/Bhutan.dx11400)
-   [Visit Downtown San Antonio](https://expedia.ca/San-Antonio-Downtown-San-Antonio.dx800120)
-   [Visit Tiki Island](https://expedia.ca/Galveston-Tiki-Island.dx3000398918)
-   [Visit Crystal Beach](https://expedia.ca/Port-Bolivar-Crystal-Beach.dx94245)
-   [Visit Downtown Austin](https://expedia.ca/Austin-Downtown-Austin.dx6059085)
-   [Visit Deep Ellum](https://expedia.ca/Dallas-Deep-Ellum.dx6190847)