Use Expedia to help you arrange a flight to Houston William Hobby Airport (HOU) airport or Houston, TX (EFD-Ellington Field) airport, and then choose from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to get what you need to make your stay relaxing and comfortable. If you want an upscale hotel with fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Texas Medical Center offers. Known for its museums and sporting events, Texas Medical Center also has some interesting things to see and do including Houston Zoo, so you may want to take in the local sights during your visit.