Find luxury hotels in Hannibal, MO

Use Expedia to arrange your flight to Quincy, IL (UIN-Quincy Regional-Baldwin Field) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you’d like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Hannibal has to offer. During your visit, you might want to enjoy the museums which Hannibal is known for.

Lie in the lap of luxury during your getaway to Hannibal in one of Expedia’s 10 luxury hotels.

Planning for the weather is a good way to make your trip to Hannibal relaxing and enjoyable, especially when you’re splurging. The hottest months are usually July and August with an average temp of 74°F, while the coldest months are January and February with an average of 34°F. Average annual precipitation for Hannibal is 47 inches.

Take in some sights and attractions while you’re in Hannibal by visiting Mark Twain Boyhood Home and Museum, Mark Twain Memorial Lighthouse, and Mark Twain Cave and Cameron Cave. If you have extra time while you’re in the area, you might want to stop by Mark Twain Cave and Mississippi River.